Search Results - "Schleich, FLorence"

Exhaled Volatile Organic Compounds Are Able to Discriminate between Neutrophilic and Eosinophilic Asthma by Schleich, Florence N, Zanella, Delphine, Stefanuto, Pierre-Hugues, Bessonov, Kirill, Smolinska, Agnieska, Dallinga, Jan W, Henket, Monique, Paulus, Virginie, Guissard, Françoise, Graff, Sophie, Moermans, Catherine, Wouters, Emiel F M, Van Steen, Kristel, van Schooten, Frederik-Jan, Focant, Jean-François, Louis, Renaud

“…Analysis of exhaled breath for asthma phenotyping using endogenously generated volatile organic compounds (VOCs) offers the possibility of noninvasive…”
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Granulocytic Airway Inflammation and Clinical Asthma Outcomes by Louis, Renaud E, Schleich, Florence N

“…In this issue of the Journal, Hastie and colleagues (pp. 882-892) report on the stability/instability of airway granulocytic inflammation by analyzing induced…”
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Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation by Schleich, Florence N, Manise, Maité, Sele, Jocelyne, Henket, Monique, Seidel, Laurence, Louis, Renaud

“…Phenotyping asthma according to airway inflammation allows identification of responders to targeted therapy. Induced sputum is technically demanding. We aimed…”
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Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts by Sun, Qingzhu, Fang, Lei, Roth, Michael, Tang, Xuemei, Papakonstantinou, Eleni, Zhai, Weiqi, Louis, Renaud, Heinen, Vincent, Schleich, Florence N, Lu, Shemin, Savic, Spasenjia, Tamm, Michael, Stolz, Daiana

“…Bronchial thermoplasty (BT) is to date the only therapy that provides a lasting reduction in airway wall remodelling. However, the mechanism of action of BT is…”
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Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis by Harrison, Tim, Canonica, Giorgio Walter, Chupp, Geoffrey, Lee, Jason, Schleich, Florence, Welte, Tobias, Valero, Antonio, Gemzoe, Kim, Maxwell, Aoife, Joksaite, Sandra, Yang, Shibing, Howarth, Peter, Van Dyke, Melissa K

“…Efficacy of mepolizumab, an anti-interleukin-5 monoclonal antibody, was demonstrated in randomised controlled trials; data on its real-world impact in routine…”
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Exhaled volatile organic compounds for better asthma control: could it be a future noninvasive adherence test? by Schleich, Florence N, Zanella, Delphine, Focant, Jean-François

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Asthma inflammatory phenotypes show differential microRNA expression in sputum by Maes, Tania, PhD, Cobos, Francisco Avila, MSc, Schleich, Florence, MD, PhD, Sorbello, Valentina, PhD, Henket, Monique, MLT, De Preter, Katleen, PhD, Bracke, Ken R., PhD, Conickx, Griet, Pharm, Mesnil, Claire, PhD, Vandesompele, Jo, PhD, Lahousse, Lies, PhD, Bureau, Fabrice, PhD, Mestdagh, Pieter, PhD, Joos, Guy F., MD, PhD, Ricciardolo, Fabio L.M., MD, PhD, Brusselle, Guy G., MD, PhD, Louis, Renaud, MD, PhD

“…Background Asthma is classified according to severity and inflammatory phenotype and is likely to be distinguished by specific microRNA (miRNA) expression…”
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European Respiratory Society Guidelines for the Diagnosis of Asthma in Adults by Louis, Renaud, Satia, Imran, Ojanguren, Inigo, Schleich, Florence, Bonini, Matteo, Tonia, Thomy, Rigau, David, Ten Brinke, Anne, Buhl, Roland, Loukides, Stelios, Kocks, Janwillem W H, Boulet, Louis-Philippe, Bourdin, Arnaud, Coleman, Courtney, Needham, Karen, Thomas, Mike, Idzko, Marco, Papi, Alberto, Porsbjerg, Celeste, Schuermans, Daniel, Soriano, Joan B, Usmani, Omar S

“…Although asthma is very common affecting 5-10% of the population, the diagnosis of asthma in adults remains a challenge in the real world that results in both…”
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Importance of concomitant local and systemic eosinophilia in uncontrolled asthma by SCHLEICH, Florence Nicole, CHEVREMONT, Anne, PAULUS, Virginie, HENKET, Monique, MANISE, Maité, SEIDEL, Laurence, LOUIS, Renaud

“…Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic…”
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Eosinophils in Health and Disease: A State-of-the-Art Review by Wechsler, Michael E., Munitz, Ariel, Ackerman, Steven J., Drake, Matthew G., Jackson, David J., Wardlaw, Andrew J., Dougan, Stephanie K., Berdnikovs, Sergejs, Schleich, Florence, Matucci, Andrea, Chanez, Pascal, Prazma, Charlene M., Howarth, Peter, Weller, Peter F., Merkel, Peter A.

“…Eosinophils play a homeostatic role in the body’s immune responses. These cells are involved in combating some parasitic, bacterial, and viral infections and…”
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Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma by Schleich, Florence N, Seidel, Laurence, Sele, Jocelyne, Manise, Maite, Quaedvlieg, Valerie, Michils, Alain, Louis, Renaud

“…It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the…”
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Blood eosinophil count to predict bronchial eosinophilic inflammation in COPD by Schleich, Florence, Corhay, Jean-Louis, Louis, Renaud

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Biomarkers in the Management of Difficult Asthma by Schleich, Florence, Demarche, Sophie, Louis, Renaud

“…Difficult asthma is a heterogeneous disease of the airways including various types of bronchial inflammation and various degrees of airway remodeling…”
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Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma by Van Hulst, Glenn, Jorssen, Joseph, Jacobs, Nathalie, Henket, Monique, Louis, Renaud, Schleich, Florence, Bureau, Fabrice, Desmet, Christophe J

“…Neutralising antibodies against the cytokine interleukin (IL)5 have become widely used for the control of severe eosinophilic asthma. Remarkably, patients…”
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Cytokine-targeted therapies for asthma and COPD by Schleich, Florence, Bougard, Nicolas, Moermans, Catherine, Sabbe, Mare, Louis, Renaud

“…Asthma affects over 300 million people worldwide and its prevalence is increasing. COPD is the third leading cause of death globally. Asthma and COPD are…”
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Lung-resident eosinophils represent a distinct regulatory eosinophil subset by Mesnil, Claire, Raulier, Stéfanie, Paulissen, Geneviève, Xiao, Xue, Birrell, Mark A, Pirottin, Dimitri, Janss, Thibaut, Starkl, Philipp, Ramery, Eve, Henket, Monique, Schleich, Florence N, Radermecker, Marc, Thielemans, Kris, Gillet, Laurent, Thiry, Marc, Belvisi, Maria G, Louis, Renaud, Desmet, Christophe, Marichal, Thomas, Bureau, Fabrice

“…Increases in eosinophil numbers are associated with infection and allergic diseases, including asthma, but there is also evidence that eosinophils contribute…”
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Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory? by Demarche, Sophie, Schleich, Florence, Henket, Monique, Paulus, Virginie, Van Hees, Thierry, Louis, Renaud

“…The technique of induced sputum has allowed to subdivide asthma patients into inflammatory phenotypes according to their level of granulocyte airway…”
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Biological Therapy of Severe Asthma and Nasal Polyps by Bakakos, Agamemnon, Schleich, Florence, Bakakos, Petros

“…Chronic rhinosinusitis is a common disease worldwide and can be categorized into chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis without…”
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Asthma Control and Sputum Eosinophils: A Longitudinal Study in Daily Practice by Demarche, Sophie F., MPharm, Schleich, Florence N., MD, PhD, Paulus, Virginie A., MLT, Henket, Monique A., MLT, Van Hees, Thierry J., MPharm, PhD, Louis, Renaud E., MD, PhD

“…Background Longitudinal trials have suggested that asthma control may be influenced by fluctuations in eosinophilic inflammation. This association has however…”
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Effectiveness of inhaled corticosteroids in real life on clinical outcomes, sputum cells and systemic inflammation in asthmatics: a retrospective cohort study in a secondary care centre by Demarche, Sophie F, Schleich, Florence N, Henket, Monique A, Paulus, Virginie A, Van Hees, Thierry J, Louis, Renaud E

“…ObjectivesThe impact of inhaled corticosteroids (ICS) on eosinophilic inflammation in asthma is well established, but their effect in a real-life setting has…”
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