Search Results - "Schlehuber, S."

Comparison of Data-Dependent Acquisition, Data-Independent Acquisition, and Parallel Reaction Monitoring in Trapped Ion Mobility Spectrometry–Time-of-Flight Tandem Mass Spectrometry-Based Lipidomics by Rudt, E., Feldhaus, M., Margraf, C. G., Schlehuber, S., Schubert, A., Heuckeroth, S., Karst, U., Jeck, V., Meyer, S. W., Korf, A., Hayen, H.

“…The parallel accumulation–serial fragmentation (PASEF) approach based on trapped ion mobility spectrometry (TIMS) enables mobility-resolved fragmentation and a…”
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Lipocalins in drug discovery: From natural ligand-binding proteins to ‘anticalins’ by Schlehuber, Steffen, Skerra, Arne

“…Lipocalins, an abundant family of ligand-binding and -transport proteins, have attracted attention as potential drugs, either based on their natural binding…”
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engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies by Schönfeld, D, Matschiner, G, Chatwell, L, Trentmann, S, Gille, H, Hülsmeyer, M, Brown, N, Kaye, P.M, Schlehuber, S, Hohlbaum, A.M, Skerra, A

“…Biomolecular reagents that enable the specific molecular recognition of proteins play a crucial role in basic research as well as medicine. Up to now,…”
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Role of the Y134F mutation in cyp51 and overexpression of cyp51 in the sensitivity response of Puccinia triticina to epoxiconazole by Stammler, G., Cordero, J., Koch, A., Semar, M., Schlehuber, S.

“…A collection of 110 isolates of Puccinia triticina in 2007 from different European wheat-growing regions were examined for their sensitivity to the…”
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Frequency of different CYP51-haplotypes of Mycosphaerella graminicola and their impact on epoxiconazole-sensitivity and -field efficacy by Stammler, G., Carstensen, M., Koch, A., Semar, M., Strobel, D., Schlehuber, S.

“…After development of QoI resistance in Mycosphaerella graminicola in intensive European wheat growing areas, demethylation inhibitors (DMIs) have become the…”
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Duocalins: engineered ligand-binding proteins with dual specificity derived from the lipocalin fold by Schlehuber, S, Skerra, A

“…Anticalins comprise a novel class of receptor proteins with predetermined ligand specificities which were engineered using the lipocalin fold. Attractive…”
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Mutations in the target protein of succinate-dehydrogenase inhibitors (SDHI) conferring changes in fungicide sensitivity by Frank, M, Glaettli, A, Schlehuber, S, Stammler, G

“…Fungicide resistance of fungal plant pathogens is mostly based on point mutations in the target proteins. Monitoring of the sensitivity of different target…”
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Anticalins as an alternative to antibody technology by Schlehuber, Steffen, Skerra, Arne

“…Anticalins are a class of engineered ligand-binding proteins that are based on the lipocalin scaffold. The lipocalin protein architecture is characterised by a…”
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A novel type of receptor protein, based on the lipocalin scaffold, with specificity for digoxigenin by Schlehuber, Steffen, Beste, Gerald, Skerra, Arne

“…We demonstrate that the bilin-binding protein, a member of the lipocalin family of proteins, can be structurally reshaped in order to specifically complex…”
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Structural Mechanism of Specific Ligand Recognition by a Lipocalin Tailored for the Complexation of Digoxigenin by Korndörfer, Ingo P, Schlehuber, Steffen, Skerra, Arne

“…DigA16 is an artificial digoxigenin-binding protein, which was derived from the bilin-binding protein, a lipocalin of Pieris brassicae, via reshaping of its…”
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Tuning ligand affinity, specificity, and folding stability of an engineered lipocalin variant — a so-called ‘anticalin’ — using a molecular random approach by Schlehuber, Steffen, Skerra, Arne

“…Anticalins are prepared by reshaping the ligand pocket of a natural lipocalin via protein engineering in order to recognize a prescribed ligand. In this…”
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Anticalins in drug development by Schlehuber, Steffen, Skerra, Arne

“…Anticalins are a novel class of engineered ligand-binding proteins that are prepared from lipocalins--conventional plasma proteins in humans--via targeted…”
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