Search Results - "Schleberger, Christian"

Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β by Hommel, Ulrich, Hurth, Konstanze, Rondeau, Jean-Michel, Vulpetti, Anna, Ostermeier, Daniela, Boettcher, Andreas, Brady, Jacob Peter, Hediger, Michael, Lehmann, Sylvie, Koch, Elke, Blechschmidt, Anke, Yamamoto, Rina, Tundo Dottorello, Valentina, Haenni-Holzinger, Sandra, Kaiser, Christian, Lehr, Philipp, Lingel, Andreas, Mureddu, Luca, Schleberger, Christian, Blank, Jutta, Ramage, Paul, Freuler, Felix, Eder, Joerg, Bornancin, Frédéric

“…Human interleukin-1β (hIL-1β) is a pro-inflammatory cytokine involved in many diseases. While hIL-1β directed antibodies have shown clinical benefit, an orally…”
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Structure and Action of the Binary C2 Toxin from Clostridium botulinum by Schleberger, Christian, Hochmann, Henrike, Barth, Holger, Aktories, Klaus, Schulz, Georg E.

“…C2 toxin from Clostridium botulinum is composed of the enzyme component C2-I, which ADP-ribosylates actin, and the binding and translocation component C2-II,…”
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Investigating the human and nonobese diabetic mouse MHC class II immunopeptidome using protein language modeling by Hartout, Philip, Počuča, Bojana, Méndez-García, Celia, Schleberger, Christian

“…Identifying peptides associated with the major histocompability complex class II (MHCII) is a central task in the evaluation of the immunoregulatory function…”
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Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa by Ude, Johanna, Tripathi, Vishwachi, Buyck, Julien M., Söderholm, Sandra, Cunrath, Olivier, Fanous, Joseph, Claudi, Beatrice, Egli, Adrian, Schleberger, Christian, Hiller, Sebastian, Bumann, Dirk

“…Gram-negative bacterial pathogens have an outer membrane that restricts entry of molecules into the cell. Water-filled protein channels in the outer membrane,…”
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A Multidisciplinary Approach toward Identification of Antibiotic Scaffolds for Acinetobacter baumannii by Bhamidimarri, Satya Prathyusha, Zahn, Michael, Prajapati, Jigneshkumar Dahyabhai, Schleberger, Christian, Söderholm, Sandra, Hoover, Jennifer, West, Josh, Kleinekathöfer, Ulrich, Bumann, Dirk, Winterhalter, Mathias, van den Berg, Bert

“…Research efforts to discover potential new antibiotics for Gram-negative bacteria suffer from high attrition rates due to the synergistic action of efflux…”
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Fragment‐Based Discovery of Non‐bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase by Münzker, Lena, Petrick, Joy Kristin, Schleberger, Christian, Clavel, Damien, Cornaciu, Irina, Wilcken, Rainer, Márquez, José A., Klebe, Gerhard, Marzinzik, Andreas, Jahnke, Wolfgang

“…Trypanosoma brucei is the causative agent of human African trypanosomiasis (HAT). Nitrogen‐containing bisphosphonates, a current treatment for bone diseases,…”
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Catechol siderophores repress the pyochelin pathway and activate the enterobactin pathway in Pseudomonas aeruginosa: an opportunity for siderophore–antibiotic conjugates development by Gasser, Véronique, Baco, Etienne, Cunrath, Olivier, August, Pamela Saint, Perraud, Quentin, Zill, Nicolas, Schleberger, Christian, Schmidt, Alexander, Paulen, Aurélie, Bumann, Dirk, Mislin, Gaëtan L. A, Schalk, Isabelle J

“…Previous studies have suggested that antibiotic vectorization by siderophores (iron chelators produced by bacteria) considerably increases the efficacy of such…”
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High-Resolution Crystal Structure of the Snake Venom Metalloproteinase BaP1 Complexed with a Peptidomimetic: Insight into Inhibitor Binding by Lingott, Torsten, Schleberger, Christian, Gutiérrez, José María, Merfort, Irmgard

“…BaP1, a zinc-dependent endopeptidase belonging to the P-I class of snake venom metalloproteinases, exerts multiple tissue-damaging activities, leading to…”
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Seed-based IntaRNA prediction combined with GFP-reporter system identifies mRNA targets of the small RNA Yfr1 by Richter, Andreas S., Schleberger, Christian, Backofen, Rolf, Steglich, Claudia

“…Motivation: Prochlorococcus possesses the smallest genome of all sequenced photoautotrophs. Although the number of regulatory proteins in the genome is very…”
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Getting Drugs through Small Pores: Exploiting the Porins Pathway in Pseudomonas aeruginosa by Samanta, Susruta, Bodrenko, Igor, Acosta-Gutiérrez, Silvia, D’Agostino, Tommaso, Pathania, Monisha, Ghai, Ishan, Schleberger, Christian, Bumann, Dirk, Wagner, Richard, Winterhalter, Mathias, van den Berg, Bert, Ceccarelli, Matteo

“…Understanding molecular properties of outer membrane channels of Gram-negative bacteria is of fundamental significance as they are the entry point of polar…”
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Catechol siderophores repress the pyochelin pathway and activate the enterobactin pathway in P seudomonas aeruginosa : an opportunity for siderophore–antibiotic conjugates development by Gasser, Véronique, Baco, Etienne, Cunrath, Olivier, August, Pamela Saint, Perraud, Quentin, Zill, Nicolas, Schleberger, Christian, Schmidt, Alexander, Paulen, Aurélie, Bumann, Dirk, Mislin, Gaëtan L. A., Schalk, Isabelle J.

“…Summary Previous studies have suggested that antibiotic vectorization by siderophores (iron chelators produced by bacteria) considerably increases the efficacy…”
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Catechol siderophores repress the pyochelin pathway and activate the enterobactin pathway in Pseudomonas aeruginosa : an opportunity for siderophore-antibiotic 2 conjugates development by Gasser, Véronique, Baco, Etienne, Cunrath, Olivier, August, Pamela Saint, Perraud, Quentin, Zill, Nicolas, Schleberger, Christian, Schmidt, Alexander, Paulen, Aurélie, Bumann, Dirk, Mislin, Gaëtan, Schalk, Isabelle

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Seed-based I nta RNA prediction combined with GFP-reporter system identifies mRNA targets of the small RNA Yfr1 by Richter, Andreas S., Schleberger, Christian, Backofen, Rolf, Steglich, Claudia

“…Abstract Motivation:  Prochlorococcus possesses the smallest genome of all sequenced photoautotrophs. Although the number of regulatory proteins in the genome…”
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Binding structure of the leucine aminopeptidase inhibitor microginin FR1 by Kraft, Manuel, Schleberger, Christian, Weckesser, Jürgen, Schulz, Georg E.

“…Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them,…”
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Structure and Action of a C?C Bond Cleaving alpha / beta -Hydrolase Involved in Nicotine Degration by Schleberger, C, Sachelaru, P, Brandsch, R, Schulz, GE

“…The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase from the nicotine-degradation pathway of Arthrobacter nicotinovorans was crystallized and the structure…”
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Binding Structure of Elastase Inhibitor Scyptolin A by Matern, Ute, Schleberger, Christian, Jelakovic, Stjepan, Weckesser, Jürgen, Schulz, Georg E

“…Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them,…”
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Structure and action of a C-C bond cleaving alpha/beta-hydrolase involved in nicotine degradation by Schleberger, Christian, Sachelaru, Paula, Brandsch, Roderich, Schulz, Georg E

“…The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase from the nicotine-degradation pathway of Arthrobacter nicotinovorans was crystallized and the structure…”
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Structure and Action of a CC Bond Cleaving α/β-Hydrolase Involved in Nicotine Degration by Schleberger, Christian, Sachelaru, Paula, Brandsch, Roderich, Schulz, Georg E.

“…The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase from the nicotine-degradation pathway of Arthrobacter nicotinovorans was crystallized and the structure…”
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Engineering a Function into a Glycosyltransferase by Krauth, Christine, Fedoryshyn, Marta, Schleberger, Christian, Luzhetskyy, Andriy, Bechthold, Andreas

“…As glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field. In this…”
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