7 Tesla MRI demonstrates vascular pathology in Baló’s concentric sclerosis

Baló’s concentric sclerosis (BCS) is an inflammatory demyelinating disease related to multiple sclerosis; its underlying pathology remains unclear. At 7 T MRI in a 19-year-old female BCS patient, microhaemorrhages and ectatic veins were found in T2 hyperintense regions, features which have not been...

Full description

Saved in:

Bibliographic Details
Published in:	Multiple sclerosis Vol. 19; no. 1; pp. 120 - 122
Main Authors:	Berghoff, M, Schlamann, MU, Maderwald, S, Grams, AE, Kaps, M, Ladd, ME, Gizewski, ER
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-01-2013 Sage Publications Sage Publications Ltd
Subjects:	Antibodies, Monoclonal, Humanized - therapeutic use Biological and medical sciences Brain - pathology Data processing Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diffuse Cerebral Sclerosis of Schilder - pathology Female Humans Immunologic Factors - therapeutic use Magnetic Resonance Imaging - methods Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Natalizumab Neurology Young Adult magnetic resonance imaging multiple sclerosis Baló’s concentric sclerosis magnetic resonance spectroscopy plasma exchange natalizumab microhaemorrhages Nervous system diseases Multiple sclerosis Natalizumab Cardiovascular disease NMR spectrometry Nuclear magnetic resonance imaging Inflammatory disease Plasma exchange Central nervous system disease Baló's concentric sclerosis Degenerative disease
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Baló’s concentric sclerosis (BCS) is an inflammatory demyelinating disease related to multiple sclerosis; its underlying pathology remains unclear. At 7 T MRI in a 19-year-old female BCS patient, microhaemorrhages and ectatic veins were found in T2 hyperintense regions, features which have not been previously reported in conjunction with BCS, and these findings may support the view that vascular pathology plays a role in BCS. MRS data suggest that neuron loss and lipid turnover still took place months after a remission. Plasma exchange was effective in treating a relapse with severe motor deficits, and the off-label use of natalizumab was successful in maintaining remission in this patient.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1352-4585 1477-0970
DOI:	10.1177/1352458512445302