Search Results - "Schlake, Thomas"

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals by Thess, Andreas, Grund, Stefanie, Mui, Barbara L, Hope, Michael J, Baumhof, Patrick, Fotin-Mleczek, Mariola, Schlake, Thomas

“…Being a transient carrier of genetic information, mRNA could be a versatile, flexible, and safe means for protein therapies. While recent findings highlight…”
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WNT and DKK Determine Hair Follicle Spacing Through a Reaction-Diffusion Mechanism by Sick, Stefanie, Reinker, Stefan, Timmer, Jens, Schlake, Thomas

“…Mathematical reaction-diffusion models have been suggested to describe formation of animal pigmentation patterns and distribution of epidermal appendages…”
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Developing mRNA-vaccine technologies by Schlake, Thomas, Thess, Andreas, Fotin-Mleczek, Mariola, Kallen, Karl-Josef

“…mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ…”
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Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection by Petsch, Benjamin, Schnee, Margit, Vogel, Annette B, Lange, Elke, Hoffmann, Bernd, Voss, Daniel, Schlake, Thomas, Thess, Andreas, Kallen, Karl-Josef, Stitz, Lothar, Kramps, Thomas

“…Petsch et al . apply mRNA vaccination for the first time to infectious disease, demonstrating immunogenicity and/or protective effects against influenza virus…”
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mRNA mediates passive vaccination against infectious agents, toxins, and tumors by Thran, Moritz, Mukherjee, Jean, Pönisch, Marion, Fiedler, Katja, Thess, Andreas, Mui, Barbara L, Hope, Michael J, Tam, Ying K, Horscroft, Nigel, Heidenreich, Regina, Fotin‐Mleczek, Mariola, Shoemaker, Charles B, Schlake, Thomas

“…The delivery of genetic information has emerged as a valid therapeutic approach. Various reports have demonstrated that mRNA, besides its remarkable potential…”
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FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5 by Schlake, Thomas

“…Reciprocal interactions between the dermal papilla and the hair matrix control proliferation and differentiation in the mature hair follicle. Analysis of…”
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Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway by Lorenz, Christina, Fotin-Mleczek, Mariola, Roth, Günter, Becker, Christina, Dam, Thanh Chau, Verdurmen, Wouter P. R., Brock, Roland, Probst, Jochen, Schlake, Thomas

“…Insertional mutagenesis and the inherent risk of malignancy compromise the clinical use of DNA-based therapies. Being a transient copy of genetic material,…”
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mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5 by Hauser, Stefan, Poenisch, Marion, Schelling, Yvonne, Höflinger, Philip, Schuster, Stefanie, Teegler, Axel, Betten, Rabea, Gustafsson, Jan-Åke, Hübener-Schmid, Jeannette, Schlake, Thomas, Chevessier-Tünnesen, Frédéric, Horscroft, Nigel, Björkhem, Ingemar, Schöls, Ludger

“…Hereditary spastic paraplegia type 5 is a neurodegenerative disease caused by loss-of-function mutations in the CYP7B1 gene encoding the oxysterol…”
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Use of Mutated FLP Recognition Target (FRT) Sites for the Exchange of Expression Cassettes at Defined Chromosomal Loci by Schlake, Thomas, Bode, Juergen

“…Using the FLP/FRT system for site-specific recombination and the wild-type recognition site (FRT) in conjunction with certain mutant FRT sites, it becomes…”
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Canonical WNT Signalling Controls Hair Follicle Spacing by Schlake, Thomas, Sick, Stefanie

“…Canonical WNT signals play an important role in hair follicle development. In addition to being crucial for epidermal appendage initiation, they control the…”
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mRNA as novel technology for passive immunotherapy by Schlake, Thomas, Thess, Andreas, Thran, Moritz, Jordan, Ingo

“…While active immunization elicits a lasting immune response by the body, passive immunotherapy transiently equips the body with exogenously generated…”
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Determination of hair structure and shape by Schlake, Thomas

“…The hair follicle attracted significant attention as a model for the investigation of diverse biological problems. Whereas its morphology and the structure of…”
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The Nude Gene Encodes a Sequence-Specific DNA Binding Protein with Homologs in Organisms that Lack an Anticipatory Immune System by Schlake, Thomas, Schorpp, Michael, Nehls, Michael, Boehm, Thomas

“…In the mouse, the product of the nude locus, Whn, is required for the keratinization of the hair shaft and the differentiation of epithelial progenitor cells…”
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mRNA: A Novel Avenue to Antibody Therapy? by Schlake, Thomas, Thran, Moritz, Fiedler, Katja, Heidenreich, Regina, Petsch, Benjamin, Fotin-Mleczek, Mariola

“…First attempts to use exogenous mRNA for protein expression in vivo were made more than 25 years ago. However, widespread appreciation of in vitro transcribed…”
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RNActive® Technology: Generation and Testing of Stable and Immunogenic mRNA Vaccines by Rauch, Susanne, Lutz, Johannes, Kowalczyk, Aleksandra, Schlake, Thomas, Heidenreich, Regina

“…Developing effective mRNA vaccines poses certain challenges concerning mRNA stability and ability to induce sufficient immune stimulation and requires a…”
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Major shifts in genomic activity accompany progression through different stages of the hair cycle by Schlake, Thomas, Beibel, Martin, Weger, Nicole, Boehm, Thomas

“…Hair follicles display a unique pattern of cyclic growth and regression involving cell proliferation, differentiation and migration. The molecular details of…”
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Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs by Hammerschmidt, Brigitte, Schlake, Thomas

“…Axial patterning is a recurrent theme during embryonic development. To elucidate its fundamental principles, the hair follicle is an attractive model due to…”
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IGF-I Signalling Controls the Hair Growth Cycle and the Differentiation of Hair Shafts by Weger, Nicole, Schlake, Thomas

“…Mesenchymal–epithelial signalling between the dermal papilla and the hair matrix regulates cell proliferation and differentiation in mature hair follicles. The…”
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A novel, disruptive vaccination technology: Self-adjuvanted RNActive® vaccines by Kallen, Karl-Josef, Heidenreich, Regina, Schnee, Margit, Petsch, Benjamin, Schlake, Thomas, Thess, Andreas, Baumhof, Patrick, Scheel, Birgit, Koch, Sven D, Fotin-Mleczek, Mariola

“…Nucleotide based vaccines represent an enticing, novel approach to vaccination. We have developed a novel immunization technology, RNActive ® vaccines, that…”
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Sequence-Optimized mRNA Vaccines Against Infectious Disease by Rauch, Susanne, Lutz, Johannes, Mühe, Janine, Kowalczyk, Aleksandra, Schlake, Thomas, Heidenreich, Regina

“…Developing effective mRNA vaccines poses certain challenges concerning mRNA stability and ability to induce sufficient immune stimulation and requires a…”
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