Search Results - "Schlagnitweit, Judith"
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Measuring Nano- to Microstructures from Relayed Dynamic Nuclear Polarization NMR
Published in Journal of physical chemistry. C (27-07-2017)“…We show how dynamic nuclear polarization (DNP) NMR can be used in combination with models for polarization dynamics to determine the domain sizes in complex…”
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2
Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA
Published in Nature (London) (02-07-2020)“…MicroRNAs (miRNAs) regulate the levels of translation of messenger RNAs (mRNAs). At present, the major parameter that can explain the selection of the target…”
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3
Efficient Detection of Structure and Dynamics in Unlabeled RNAs: The SELOPE Approach
Published in Chemistry : a European journal (20-04-2018)“…The knowledge of structure and dynamics is crucial to explain the function of RNAs. While nuclear magnetic resonance (NMR) is well suited to probe these for…”
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4
Enzymatic incorporation of an isotope-labeled adenine into RNA for the study of conformational dynamics by NMR
Published in PloS one (08-07-2022)“…Solution NMR spectroscopy is a well-established tool with unique advantages for structural studies of RNA molecules. However, for large RNA sequences, the NMR…”
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5
Mutate-and-chemical-shift-fingerprint (MCSF) to characterize excited states in RNA using NMR spectroscopy
Published in Nature protocols (01-11-2021)“…It is important to understand the dynamics and higher energy structures of RNA, called excited states, to achieve better understanding of RNA function. R 1ρ…”
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6
Observing an Antisense Drug Complex in Intact Human Cells by in‐Cell NMR Spectroscopy
Published in Chembiochem : a European journal of chemical biology (01-10-2019)“…Gaining insight into the uptake, trafficking and target engagement of drugs in cells can enhance understanding of a drug's function and efficiency. However,…”
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7
Nonlinear detection of secondary isotopic chemical shifts in NMR through spin noise
Published in Nature communications (09-01-2017)“…The detection of minor species in the presence of large amounts of similar main components remains a key challenge in analytical chemistry, for instance, to…”
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8
Erratum: Nonlinear detection of secondary isotopic chemical shifts in NMR through spin noise
Published in Nature communications (19-04-2017)“…Nature Communications 8: Article number: 13914 (2017); Published 9 January 2017; Updated 19 April 2017 This Article contains typographical errors in Equation…”
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9
RNA Dynamics by NMR Spectroscopy
Published in Chembiochem : a European journal of chemical biology (04-11-2019)“…An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA function relies on changes in its structure, so‐called dynamics. To…”
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10
Polarizing agents for efficient high field DNP solid-state NMR spectroscopy under magic-angle spinning: from design principles to formulation strategies
Published in Chemical science (Cambridge) (14-06-2023)“…Dynamic Nuclear Polarization (DNP) has recently emerged as a cornerstone approach to enhance the sensitivity of solid-state NMR spectroscopy under Magic Angle…”
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11
Front Cover: RNA Dynamics by NMR Spectroscopy (ChemBioChem 21/2019)
Published in Chembiochem : a European journal of chemical biology (04-11-2019)“…The front cover picture shows RNA molecules dancing to the beat of nuclear magnetic resonance (NMR). In their review, K. Petzold et al. look at the different…”
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12
Capturing Excited States in the Fast-Intermediate Exchange Limit in Biological Systems Using 1HNMR Spectroscopy
Published in Angewandte Chemie International Edition (19-12-2016)“…Changes in molecular structure are essential for the function of biomolecules. Characterization of these structural fluctuations can illuminate alternative…”
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13
Mutate-and-chemical-shift-fingerprint
Published in Nature protocols (01-11-2021)“…It is important to understand the dynamics and higher energy structures of RNA, called excited states, to achieve better understanding of RNA function…”
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14
Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement
Published in Journal of the American Chemical Society (07-10-2015)“…Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE)…”
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15
Capturing Excited States in the Fast-Intermediate Exchange Limit in Biological Systems Using 1H NMR Spectroscopy
Published in Angewandte Chemie International Edition (19-12-2016)“…Changes in molecular structure are essential for the function of biomolecules. Characterization of these structural fluctuations can illuminate alternative…”
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16
High-resolution NMR of hydrogen in organic solids by DNP enhanced natural abundance deuterium spectroscopy
Published in Journal of magnetic resonance (1997) (01-10-2015)“…[Display omitted] •DNP enables rapid acquisition of natural abundance 2H solid-state NMR spectra.•The spectra enable measurement of EFG tensor parameters and…”
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17
Comprehensive analysis of NMR data using advanced line shape fitting
Published in Journal of biomolecular NMR (01-10-2017)“…NMR spectroscopy is uniquely suited for atomic resolution studies of biomolecules such as proteins, nucleic acids and metabolites, since detailed information…”
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18
Capturing Excited States in the Fast-Intermediate Exchange Limit in Biological Systems Using (HNMR)-H-1 Spectroscopy
Published in Angewandte Chemie International Edition (2016)“…Changes in molecular structure are essential for the function of biomolecules. Characterization of these structural fluctuations can illuminate alternative…”
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19
The first observation of Carbon-13 spin noise spectra
Published in Journal of magnetic resonance (1997) (01-11-2012)“…[Display omitted] ► We report the first observation of Carbon-13 spin noise spectra. ► Non-linear amplitude response at high concentration indicates the…”
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20
A solid-state NMR method to determine domain sizes in multi-component polymer formulations
Published in Journal of magnetic resonance (1997) (01-12-2015)“…[Display omitted] •Monitoring spin diffusion in multi-component systems.•A carbon-edited mobility-filtered proton spin-diffusion solid-state NMR pulse…”
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