Search Results - "Schlager, Max A"

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites by van Spronsen, Myrrhe, Mikhaylova, Marina, Lipka, Joanna, Schlager, Max A., van den Heuvel, Dave J., Kuijpers, Marijn, Wulf, Phebe S., Keijzer, Nanda, Demmers, Jeroen, Kapitein, Lukas C., Jaarsma, Dick, Gerritsen, Hans C., Akhmanova, Anna, Hoogenraad, Casper C.

“…In neurons, the distinct molecular composition of axons and dendrites is established through polarized targeting mechanisms, but it is currently unclear how…”
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In vitro reconstitution of a highly processive recombinant human dynein complex by Schlager, Max A, Hoang, Ha Thi, Urnavicius, Linas, Bullock, Simon L, Carter, Andrew P

“…Cytoplasmic dynein is an approximately 1.4 MDa multi‐protein complex that transports many cellular cargoes towards the minus ends of microtubules. Several in…”
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The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition by Belyy, Vladislav, Schlager, Max A., Foster, Helen, Reimer, Armando E., Carter, Andrew P., Yildiz, Ahmet

“…It has been unclear how the relatively weak dynein motor can counterbalance kinesin forces during microtubule-dependent transport. Belyy et al.  find that…”
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BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures by Splinter, Daniël, Razafsky, David S, Schlager, Max A, Serra-Marques, Andrea, Grigoriev, Ilya, Demmers, Jeroen, Keijzer, Nanda, Jiang, Kai, Poser, Ina, Hyman, Anthony A, Hoogenraad, Casper C, King, Stephen J, Akhmanova, Anna

“…Cytoplasmic dynein is the major microtubule minus-end-directed cellular motor. Most dynein activities require dynactin, but the mechanisms regulating…”
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Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements by Schlager, Max A., Serra-Marques, Andrea, Grigoriev, Ilya, Gumy, Laura F., Esteves da Silva, Marta, Wulf, Phebe S., Akhmanova, Anna, Hoogenraad, Casper C.

“…Cargo transport along microtubules is driven by the collective function of microtubule plus- and minus-end-directed motors (kinesins and dyneins). How the…”
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Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay by Kapitein, Lukas C., Schlager, Max A., van der Zwan, Wouter A., Wulf, Phebe S., Keijzer, Nanda, Hoogenraad, Casper C.

“…Although purified cytoskeletal motor proteins have been studied extensively with the use of in vitro approaches, a generic approach to selectively probe actin…”
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Relative and Absolute Quantification of Postsynaptic Density Proteome Isolated from Rat Forebrain and Cerebellum by Cheng, Dongmei, Hoogenraad, Casper C, Rush, John, Ramm, Elizabeth, Schlager, Max A, Duong, Duc M, Xu, Ping, Wijayawardana, Sameera R, Hanfelt, John, Nakagawa, Terunaga, Sheng, Morgan, Peng, Junmin

“…The postsynaptic density (PSD) of central excitatory synapses is essential for postsynaptic signaling, and its components are heterogeneous among different…”
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Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis by Schlager, Max A, Kapitein, Lukas C, Grigoriev, Ilya, Burzynski, Grzegorz M, Wulf, Phebe S, Keijzer, Nanda, de Graaff, Esther, Fukuda, Mitsunori, Shepherd, Iain T, Akhmanova, Anna, Hoogenraad, Casper C

“…Membrane and secretory trafficking are essential for proper neuronal development. However, the molecular mechanisms that organize secretory trafficking are…”
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Basic mechanisms for recognition and transport of synaptic cargos by Schlager, Max A, Hoogenraad, Casper C

“…Synaptic cargo trafficking is essential for synapse formation, function and plasticity. In order to transport synaptic cargo, such as synaptic vesicle…”
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The GRIP1/14-3-3 Pathway Coordinates Cargo Trafficking and Dendrite Development by Geiger, Julia C., Lipka, Joanna, Segura, Inmaculada, Hoyer, Susanne, Schlager, Max A., Wulf, Phebe S., Weinges, Stefan, Demmers, Jeroen, Hoogenraad, Casper C., Acker-Palmer, Amparo

“…Regulation of cargo transport via adaptor molecules is essential for neuronal development. However, the role of PDZ scaffolding proteins as adaptors in…”
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The structure of the dynactin complex and its interaction with dynein by Urnavicius, Linas, Zhang, Kai, Diamant, Aristides G., Motz, Carina, Schlager, Max A., Yu, Minmin, Patel, Nisha A., Robinson, Carol V., Carter, Andrew P.

“…Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report the structure of the 23-subunit dynactin complex by cryo-electron…”
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DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein–dynactin–cargo adaptor complexes by Hoang, Ha Thi, Schlager, Max A., Carter, Andrew P., Bullock, Simon L.

“…Mutations in the human DYNC1H1 gene are associated with neurological diseases. DYNC1H1 encodes the heavy chain of cytoplasmic dynein-1, a 1.4-MDa motor complex…”
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A role for the Rab6B Bicaudal–D1 interaction in retrograde transport in neuronal cells by Wanschers, Bas F.J., van de Vorstenbosch, Rinske, Schlager, Max A., Splinter, Daniël, Akhmanova, Anna, Hoogenraad, Casper C., Wieringa, Bé, Fransen, Jack A.M.

“…The Rab6 subfamily of small GTPases consists of three different isoforms: Rab6A, Rab6A′ and Rab6B. Both Rab6A and Rab6A′ are ubiquitously expressed whereas…”
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Mixed Microtubules Steer Dynein-Driven Cargo Transport into Dendrites by Kapitein, Lukas C., Schlager, Max A., Kuijpers, Marijn, Wulf, Phebe S., van Spronsen, Myrrhe, MacKintosh, Frederick C., Hoogenraad, Casper C.

“…To establish and maintain their polarized morphology, neurons employ active transport driven by molecular motors to sort cargo between axons and dendrites…”
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A role for Bicaudal-D2 in radial cerebellar granule cell migration by Jaarsma, Dick, van den Berg, Robert, Wulf, Phebe S., van Erp, Susan, Keijzer, Nanda, Schlager, Max A., de Graaff, Esther, De Zeeuw, Chris I., Pasterkamp, R. Jeroen, Akhmanova, Anna, Hoogenraad, Casper C.

“…Bicaudal-D (BICD) belongs to an evolutionary conserved family of dynein adaptor proteins. It was first described in Drosophila as an essential factor in fly…”
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Corrigendum: A role for Bicaudal-D2 in radial cerebellar granule cell migration by Jaarsma, Dick, Van Den Berg, Robert, Wulf, Phebe S, Van Erp, Susan, Keijzer, Nanda, Schlager, Max A, De Graaff, Esther, De Zeeuw, Chris I, Pasterkamp, R Jeroen, Akhmanova, Anna, Hoogenraad, Casper C

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A role for Bicaudal-D2 in radial cerebellar granule cell migration by Jaarsma, Dick, van den Berg, Robert, Wulf, Phebe S., van Erp, Susan, Keijzer, Nanda, Schlager, Max A., de Graaff, Esther, De Zeeuw, Chris I., Pasterkamp, R. Jeroen, Akhmanova, Anna, Hoogenraad, Casper C.

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Single-Molecule Insight into the Activation of Human Dynein by Adapter Proteins by Belyy, Vladislav, Schlager, Max A., Reimer, Armando E., Carter, Andrew P., Yildiz, Ahmet

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Correction: Corrigendum: A role for Bicaudal-D2 in radial cerebellar granule cell migration by Jaarsma, Dick, van den Berg, Robert, Wulf, Phebe S., van Erp, Susan, Keijzer, Nanda, Schlager, Max A., de Graaff, Esther, De Zeeuw, Chris I., Pasterkamp, R. Jeroen, Akhmanova, Anna, Hoogenraad, Casper C.

“…Nature Communications 5: Article number: 3411 (2014); Published: 11 March 2014; Updated: 7 July 2014. The affiliation details for Susan van Erp are incorrect…”
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Relative and Absolute Quantification of Postsynaptic Density Proteome Isolated from Rat Forebrain and CerebellumS by Cheng, Dongmei, Hoogenraad, Casper C., Rush, John, Ramm, Elizabeth, Schlager, Max A., Duong, Duc M., Xu, Ping, Wijayawardana, Sameera R., Hanfelt, John, Nakagawa, Terunaga, Sheng, Morgan, Peng, Junmin

“…The postsynaptic density (PSD) of central excitatory synapses is essential for postsynaptic signaling, and its components are heterogeneous among different…”
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