Search Results - "Schlage, Walter K."

The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction by Lo Sasso, Giuseppe, Schlage, Walter K, Boué, Stéphanie, Veljkovic, Emilija, Peitsch, Manuel C, Hoeng, Julia

“…Atherosclerosis-prone apolipoprotein E-deficient (Apoe(-/-)) mice display poor lipoprotein clearance with subsequent accumulation of cholesterol ester-enriched…”
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Opportunities, Challenges, and Scientific Progress in Hemp Crops by Kaminski, Kacper Piotr, Hoeng, Julia, Goffman, Fernando, Schlage, Walter K, Latino, Diogo

“…The resurgence of cannabis ( L.) has been propelled by changes in the legal framework governing its cultivation and use, increased demand for hemp-derived…”
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Review of the current ongoing clinical trials exploring the possible anti-anxiety effects of cannabidiol by Bhuller, Rhenu, Schlage, Walter K, Hoeng, Julia

“…Anxiety disorders (ADs) are a complex group of mental disorders and majorly contribute to the global health-related burden. Symptoms and clinical management…”
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Recent advances in the development of portable technologies and commercial products to detect Δ9-tetrahydrocannabinol in biofluids: a systematic review by Clément, Pierrick, Schlage, Walter K., Hoeng, Julia

“…Abstract Background The primary components driving the current commercial fascination with cannabis products are phytocannabinoids, a diverse group of over 100…”
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Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two Nicotiana Species by Laszlo, Csaba, Kaminski, Kacper, Guan, Haifeng, Fatarova, Maria, Wei, Jianbing, Bergounioux, Alexandre, Schlage, Walter K, Schorderet-Weber, Sandra, Guy, Philippe A, Ivanov, Nikolai V, Lamottke, Kai, Hoeng, Julia

“…There is an increasingly urgent call to shift industrial processes from fossil fuel feedstock to sustainable bio-based resources. This change becomes of high…”
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A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product by Phillips, Blaine, Veljkovic, Emilija, Peck, Michael J., Buettner, Ansgar, Elamin, Ashraf, Guedj, Emmanuel, Vuillaume, Gregory, Ivanov, Nikolai V., Martin, Florian, Boué, Stéphanie, Schlage, Walter K., Schneider, Thomas, Titz, Bjoern, Talikka, Marja, Vanscheeuwijck, Patrick, Hoeng, Julia, Peitsch, Manuel C.

“…•Lung inflammation and emphysema increased from 2 to 7 month CS exposure.•Cessation reverted most inflammatory processes and halted emphysematous…”
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Iota-carrageenan extracted from red algae is a potent inhibitor of SARS‐CoV-2 infection in reconstituted human airway epithelia by Bovard, David, van der Toorn, Marco, Schlage, Walter K., Constant, Samuel, Renggli, Kasper, Peitsch, Manuel C., Hoeng, Julia

“…Iota-carrageenan (IC) nasal spray, a medical device approved for treating respiratory viral infections, has previously been shown to inhibit the ability of a…”
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Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products by van der Toorn, Marco, Koshibu, Kyoko, Schlage, Walter K., Majeed, Shoaib, Pospisil, Pavel, Hoeng, Julia, Peitsch, Manuel C.

“…[Display omitted] •Aerosol fractions from heated tobacco and e-cigarettes do not inhibit MAO activity.•Smoke fractions from burned (cigarette) and extracts…”
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Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence by Gebel, Stephan, Lichtner, Rosemarie B., Frushour, Brian, Schlage, Walter K., Hoang, Vy, Talikka, Marja, Hengstermann, Arnd, Mathis, Carole, Veljkovic, Emilija, Peck, Michael, Peitsch, Manuel C., Deehan, Renee, Hoeng, Julia, Westra, Jurjen W.

“…Towards the development of a systems biology-based risk assessment approach for environmental toxicants, including tobacco products in a systems toxicology…”
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Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case by Schlage, Walter K., Titz, Bjoern, Iskandar, Anita, Poussin, Carine, Van der Toorn, Marco, Wong, Ee Tsin, Pratte, Pascal, Maeder, Serge, Schaller, Jean-Pierre, Pospisil, Pavel, Boue, Stephanie, Vuillaume, Grégory, Leroy, Patrice, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…[Display omitted] •Heated tobacco products tested for reduced exposure and reduced risk properties.•Bridging opportunities for nonclinical results from two…”
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A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue by Westra, Jurjen W., Schlage, Walter K., Hengstermann, Arnd, Gebel, Stephan, Mathis, Carole, Thomson, Ty, Wong, Ben, Hoang, Vy, Veljkovic, Emilija, Peck, Michael, Lichtner, Rosemarie B., Weisensee, Dirk, Talikka, Marja, Deehan, Renee, Hoeng, Julia, Peitsch, Manuel C.

“…Exposure to environmental stressors such as cigarette smoke (CS) elicits a variety of biological responses in humans, including the induction of inflammatory…”
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Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints by Phillips, Blaine, Titz, Bjoern, Kogel, Ulrike, Sharma, Danilal, Leroy, Patrice, Xiang, Yang, Vuillaume, Grégory, Lebrun, Stefan, Sciuscio, Davide, Ho, Jenny, Nury, Catherine, Guedj, Emmanuel, Elamin, Ashraf, Esposito, Marco, Krishnan, Subash, Schlage, Walter K., Veljkovic, Emilija, Ivanov, Nikolai V., Martin, Florian, Peitsch, Manuel C., Hoeng, Julia, Vanscheeuwijck, Patrick

“…While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been…”
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Enhancement of COPD biological networks using a web-based collaboration interface [version 2; peer review: 3 approved] by Boué, Stéphanie, Fields, Brett, Hoeng, Julia, Park, Jennifer, Peitsch, Manuel C, Schlage, Walter K, Talikka, Marja, Binenbaum, Ilona, Bondarenko, Vladimir, Bulgakov, Oleg V, Cherkasova, Vera, Diaz-Diaz, Norberto, Fedorova, Larisa, Guryanova, Svetlana, Guzova, Julia, Igorevna Koroleva, Galina, Kozhemyakina, Elena, Kumar, Rahul, Lavid, Noa, Lu, Qingxian, Menon, Swapna, Ouliel, Yael, Peterson, Samantha C, Prokhorov, Alexander, Sanders, Edward, Schrier, Sarah, Schwaitzer Neta, Golan, Shvydchenko, Irina, Tallam, Aravind, Villa-Fombuena, Gema, Wu, John, Yudkevich, Ilya, Zelikman, Mariya

“…The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease…”
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A 6-month systems toxicology inhalation study in ApoE -/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke by Szostak, Justyna, Wong, Ee Tsin, Titz, Bjoern, Lee, Tom, Wong, Sin Kei, Low, Tiffany, Lee, Kyeonghee Monica, Zhang, Jingjie, Kumar, Ashutosh, Schlage, Walter K, Guedj, Emmanuel, Phillips, Blaine, Leroy, Patrice, Buettner, Ansgar, Xiang, Yang, Martin, Florian, Sewer, Alain, Kuczaj, Arkadiusz, Ivanov, Nikolai V, Luettich, Karsta, Vanscheeuwijck, Patrick, Peitsch, Manuel C, Hoeng, Julia

“…Smoking cigarettes is harmful to the cardiovascular system. Considerable attention has been paid to the reduced harm potential of alternative…”
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Deconvolution of Systemic Pharmacokinetics Predicts Inhaled Aerosol Dosimetry of Nicotine by Kolli, Aditya R., Calvino-Martin, Florian, Kuczaj, Arkadiusz K., Wong, Ee Tsin, Titz, Bjoern, Xiang, Yang, Lebrun, Stefan, Schlage, Walter K., Vanscheeuwijck, Patrick, Hoeng, Julia

“…•Physiologically based pharmacokinetic (PBPK) model integrating lysosomal distribution for nicotine was developed for improved prediction of systemic…”
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On Crowd-verification of Biological Networks by Ansari, Sam, Binder, Jean, Boue, Stephanie, Di Fabio, Anselmo, Hayes, William, Hoeng, Julia, Iskandar, Anita, Kleiman, Robin, Norel, Raquel, O'neel, Bruce, Peitsch, Manuel C., Poussin, Carine, Pratt, Dexter, Rhrissorrakrai, Kahn, Schlage, Walter K., Stolovitzky, Gustavo, Talikka, Marja

“…Biological networks with a structured syntax are a powerful way of representing biological information generated from high density data; however, they can…”
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Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures by Sosnowski, Tomasz R., Jabłczyńska, Katarzyna, Odziomek, Marcin, Schlage, Walter K., Kuczaj, Arkadiusz K.

“…Direct physicochemical interactions between the major components of electronic cigarette liquids (e-liquids): glycerol (VG) and propylene glycol (PG), and lung…”
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An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes by Phillips, Blaine, Veljkovic, Emilija, Boué, Stéphanie, Schlage, Walter K, Vuillaume, Gregory, Martin, Florian, Titz, Bjoern, Leroy, Patrice, Buettner, Ansgar, Elamin, Ashraf, Oviedo, Alberto, Cabanski, Maciej, De León, Héctor, Guedj, Emmanuel, Schneider, Thomas, Talikka, Marja, Ivanov, Nikolai V, Vanscheeuwijck, Patrick, Peitsch, Manuel C, Hoeng, Julia

“…Smoking cigarettes is a major risk factor in the development and progression of cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD)…”
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Case study: the role of mechanistic network models in systems toxicology by Hoeng, Julia, Talikka, Marja, Martin, Florian, Sewer, Alain, Yang, Xiang, Iskandar, Anita, Schlage, Walter K., Peitsch, Manuel C.

“…•Biological network models enable a mechanistic understanding of high-throughput data.•Network response can be quantified for the impact of a given…”
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A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes by Kogel, Ulrike, Schlage, Walter K., Martin, Florian, Xiang, Yang, Ansari, Sam, Leroy, Patrice, Vanscheeuwijck, Patrick, Gebel, Stephan, Buettner, Ansgar, Wyss, Christoph, Esposito, Marco, Hoeng, Julia, Peitsch, Manuel C.

“…•OECD 28-day inhalation study: Histopathology was combined with transcriptomics.•Histopathological changes correlated with biological network…”
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