Search Results - "Schlüter, Thomas"

GEOSITES AS A POTENTIAL FOR THE DEVELOPMENT OF TOURISM – OVERVIEW OF RELEVANT SITES IN ESWATINI (FORMERLY SWAZILAND) by Thomas, SCHLUTER, Andreas, SCHUMANN

“…Despite being one of the smallest countries in Africa, the Kingdom of Eswatini (formerly Swaziland) is characterized by many locations, which are due to their…”
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FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model by Deuschle, Ulrich, Schüler, Julia, Schulz, Andreas, Schlüter, Thomas, Kinzel, Olaf, Abel, Ulrich, Kremoser, Claus

“…The farnesoid X receptor (FXR) is expressed predominantly in tissues exposed to high levels of bile acids and controls bile acid and lipid homeostasis…”
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Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice by Hambruch, Eva, Miyazaki-Anzai, Shinobu, Hahn, Ulrike, Matysik, Silke, Boettcher, Alfred, Perović-Ottstadt, Sanja, Schlüter, Thomas, Kinzel, Olaf, Krol, Helen Desiree, Deuschle, Ulrich, Burnet, Michael, Levi, Moshe, Schmitz, Gerd, Miyazaki, Makoto, Kremoser, Claus

“…Farnesoid X receptor (FXR), a bile acid-activated nuclear hormone receptor, plays an important role in the regulation of cholesterol and more specifically…”
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CRISPR/Cas9-mediated knockout of c-REL in HeLa cells results in profound defects of the cell cycle by Slotta, Carsten, Schlüter, Thomas, Ruiz-Perera, Lucia M, Kadhim, Hussamadin M, Tertel, Tobias, Henkel, Elena, Hübner, Wolfgang, Greiner, Johannes F W, Huser, Thomas, Kaltschmidt, Barbara, Kaltschmidt, Christian

“…Cervical cancer is the fourth common cancer in women resulting worldwide in 266,000 deaths per year. Belonging to the carcinomas, new insights into cervical…”
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Effects of Implantable Cardioverter Defibrillator Implantation and Shock Application on Biochemical Markers of Myocardial Damage by Schluter, Thomas, Baum, Hannsjorg, Plewan, Andreas, Neumeier, Dieter

“…Implantable cardioverter defibrillator (ICD) implantation is a common approach in patients at high risk of sudden cardiac death. To check for normal function,…”
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Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin by Williams, Ross, Schlüter, Thomas, Roberts, Marnie S, Knauth, Peter, Bohnensack, Ralf, Cutler, Daniel F

“…The transient appearance of P-selectin on the surface of endothelial cells helps recruit leukocytes into sites of inflammation. The tight control of cell…”
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An Eocene fossil scarab beetle (Coleoptera: Scarabaeoidea) from Tanzania by Strümpher, Werner P., Scholtz, Clarke H., Schlüter, Thomas

“…A fossil scarabaeoid (Coleoptera: Scarabaeoidea) Mahengea mckayi new genus, new species - the only well-preserved insect fossil and one of only a few insects…”
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Regulation of IL-1 signaling by the decoy receptor IL-1R2 by Schlüter, Thomas, Schelmbauer, Carsten, Karram, Khalad, Mufazalov, Ilgiz A.

“…The pleiotropic cytokine IL-1 mediates its biological functions via association with the signaling receptor IL-1R1. Despite an apparent simplicity in IL-1…”
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AFM13 in Combination with Allogeneic Natural Killer Cells (AB-101) in Relapsed or Refractory Hodgkin Lymphoma and CD30 + Peripheral T-Cell Lymphoma: A Phase 2 Study (LuminICE) by Moskowitz, Alison, Harstrick, Andreas, Emig, Michael, Overesch, Andre, Pinto, Sheena, Ravenstijn, Paulien, Schlüter, Thomas, Rubel, Jennifer, Rebscher, Hans, Graefe, Thorsten, Lim, John, Raymon, Heather, Alexis, Karenza

“…Background and Significance Limited treatment options are available for patients with relapsed or refractory (R/R) Hodgkin lymphoma (HL) and no…”
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Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt by Gege, Christian, Schlüter, Thomas, Hoffmann, Thomas

“…[Display omitted] Retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt) is a key transcription factor for the development of Th17 cells…”
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A Water-free 0.1% Cyclosporine A Solution for Treatment of Dry Eye Disease: Results of the Randomized Phase 2B/3 ESSENCE Study by Sheppard, John D., Wirta, David L., McLaurin, Eugene, Boehmer, Blair E., Ciolino, Joseph B., Meides, Alice S., Schlüter, Thomas, Ousler, George W., Usner, Dale, Krösser, Sonja

“…To assess the efficacy, safety, and tolerability of a topical water-free cyclosporine A formulation (CyclASol 0.1% ophthalmic solution) in comparison with…”
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Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis by Kämper, J, Kahmann, R, Bölker, M, Ma, L.J, Brefort, T, Saville, B.J, Banuett, F, Kronstad, J.W, Gold, S.E, Müller, O

“…Ustilago maydis is a ubiquitous pathogen of maize and a well-established model organism for the study of plant-microbe interactions. This basidiomycete fungus…”
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Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt by Gege, Christian, Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Hoffmann, Thomas, Xue, Xiaohua, Cummings, Maxwell D., Spurlino, John, Milligan, Cynthia, Fourie, Anne M., Edwards, James P., Leonard, Kristi, Coe, Kevin, Scott, Brian, Pippel, Dan, Goldberg, Steven D.

“…[Display omitted] The nuclear receptor retinoic acid receptor-related orphan receptor gamma t (RORγt) is a transcription factor that drives Th17 cell…”
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Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach by Steeneck, Christoph, Gege, Christian, Kinzel, Olaf, Albers, Michael, Kleymann, Gerald, Schlüter, Thomas, Schulz, Andreas, Xue, Xiaohua, Cummings, Maxwell D., Fourie, Anne M., Leonard, Kristi A., Scott, Brian, Edwards, James P., Hoffmann, Thomas, Goldberg, Steven D.

“…[Display omitted] Starting from previously identified thiazole-2-carboxamides exemplified by compound 1/6, two new series of RORγt inverse agonists with…”
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Performance Management in a German 'Hidden Champion' : an Action Research Investigation by Schlüter, Thomas

“…Purpose - This thesis addresses the lack of research on Performance Management (PM) in Hidden Champions (HCs) due to development and implementation of a HC…”
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Moltenia rieki n. gen., n. sp. (Hymenoptera: Xyelidae?, a tentative sawfly from the Molteno Formation (Upper Triassic), South Africa by Schlüter, Thomas

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Identification and biological evaluation of thiazole-based inverse agonists of RORγt by Gege, Christian, Cummings, Maxwell D., Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Nelen, Marina I., Milligan, Cindy, Spurlino, John, Xue, Xiaohua, Leonard, Kristi, Edwards, James P., Fourie, Anne, Goldberg, Steven D., Hoffmann, Thomas

“…[Display omitted] •A new class of potent RORγt inverse agonists based on a thiazole core described.•X-ray data (PDB ID 6CVH) helped to elucidate the molecular…”
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Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties by Kinzel, Olaf, Steeneck, Christoph, Schlüter, Thomas, Schulz, Andreas, Gege, Christian, Hahn, Ulrike, Hambruch, Eva, Hornberger, Martin, Spalwisz, Adriana, Frick, Katharina, Perović-Ottstadt, Sanja, Deuschle, Ulrich, Burnet, Michael, Kremoser, Claus

“…[Display omitted] Several isoxazole-containing series of FXR agonists have been published over the last 15years, subsequent to the prototypical amphiphilic…”
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Effect of the cytostatic agent idarubicin on fibroblasts of the human Tenon’s capsule compared with mitomycin C by Heilmann, Claudia, Schönfeld, Peter, Schlüter, Thomas, Bohnensack, Ralf, Behrens-Baumann, Wolfgang

“…BACKGROUND/AIMS To investigate the in vitro effect of a short time exposure to the anthracycline idarubicin on proliferation, protein synthesis, and motility…”
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Effect of heavy metal ions on the release of reactive oxygen intermediates by bovine alveolar macrophages by Schlüter, Thomas, Berg, Ingeborg, Dörger, Martina, Gercken, Günther

“…Short-term incubations of bovine alveolar macrophages (BAM) with metal-containing dusts induce the release of reactive oxygen intermediates (ROI). Incubations…”
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