Search Results - "Schissler, A Grant"

Developing a ‘personalome’ for precision medicine: emerging methods that compute interpretable effect sizes from single-subject transcriptomes by Vitali, Francesca, Li, Qike, Schissler, A Grant, Berghout, Joanne, Kenost, Colleen, Lussier, Yves A

“…Abstract The development of computational methods capable of analyzing -omics data at the individual level is critical for the success of precision medicine…”
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Autologistic models for benchmark risk or vulnerability assessment of urban terrorism outcomes by Liu, Jingyu, Piegorsch, Walter W., Schissler, A. Grant, Cutter, Susan L.

“…We develop a quantitative methodology to characterize vulnerability among 132 US urban centres (‘cities’) to terrorist events, applying a place-based…”
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NBIA: a network-based integrative analysis framework – applied to pathway analysis by Nguyen, Tin, Shafi, Adib, Nguyen, Tuan-Minh, Schissler, A. Grant, Draghici, Sorin

“…With the explosion of high-throughput data, effective integrative analyses are needed to decipher the knowledge accumulated in biological databases. Existing…”
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Statistical Comparison and Assessment of Four Fire Emissions Inventories for 2013 and a Large Wildfire in the Western United States by Faulstich, Sam D, Schissler, A Grant, Strickland, Matthew J, Holmes, Heather A

“…Wildland fires produce smoke plumes that impact air quality and human health. To understand the effects of wildland fire smoke on humans, the amount and…”
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Testing for differentially expressed genetic pathways with single-subject N-of-1 data in the presence of inter-gene correlation by Schissler, A Grant, Piegorsch, Walter W, Lussier, Yves A

“…Modern precision medicine increasingly relies on molecular data analytics, wherein development of interpretable single-subject (“N-of-1”) signals is a…”
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Adjusting statistical benchmark risk analysis to account for non-spatial autocorrelation, with application to natural hazard risk assessment by Liu, Jingyu, Piegorsch, Walter W., Schissler, A. Grant, McCaster, Rachel R., Cutter, Susan L.

“…We develop and study a quantitative, interdisciplinary strategy for conducting statistical risk analyses within the 'benchmark risk' paradigm of contemporary…”
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N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes by Li, Qike, Schissler, A Grant, Gardeux, Vincent, Achour, Ikbel, Kenost, Colleen, Berghout, Joanne, Li, Haiquan, Zhang, Hao Helen, Lussier, Yves A

“…Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes. However, as precision medicine pursues…”
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Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival by Schissler, A Grant, Gardeux, Vincent, Li, Qike, Achour, Ikbel, Li, Haiquan, Piegorsch, Walter W, Lussier, Yves A

“…The conventional approach to personalized medicine relies on molecular data analytics across multiple patients. The path to precision medicine lies with…”
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A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations by Gardeux, Vincent, Berghout, Joanne, Achour, Ikbel, Schissler, A Grant, Li, Qike, Kenost, Colleen, Li, Jianrong, Shang, Yuan, Bosco, Anthony, Saner, Donald, Halonen, Marilyn J, Jackson, Daniel J, Li, Haiquan, Martinez, Fernando D, Lussier, Yves A

“…Abstract Objective To introduce a disease prognosis framework enabled by a robust classification scheme derived from patient-specific transcriptomic response…”
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Analysis of aggregated cell-cell statistical distances within pathways unveils therapeutic-resistance mechanisms in circulating tumor cells by Schissler, A Grant, Li, Qike, Chen, James L, Kenost, Colleen, Achour, Ikbel, Billheimer, D Dean, Li, Haiquan, Piegorsch, Walter W, Lussier, Yves A

“…As 'omics' biotechnologies accelerate the capability to contrast a myriad of molecular measurements from a single cell, they also exacerbate current analytical…”
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kMEn: Analyzing noisy and bidirectional transcriptional pathway responses in single subjects by Li, Qike, Schissler, A. Grant, Gardeux, Vincent, Berghout, Joanne, Achour, Ikbel, Kenost, Colleen, Li, Haiquan, Zhang, Hao Helen, Lussier, Yves A.

“…[Display omitted] •A method to unveil dynamic, patient-level transcriptomic response to therapy.•First method to detect bidirectional pathway dysregulation…”
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A flexible multivariate model for high-dimensional correlated count data by Knudson, Alexander D., Kozubowski, Tomasz J., Panorska, Anna K., Schissler, A. Grant

“…We propose a flexible multivariate stochastic model for over-dispersed count data. Our methodology is built upon mixed Poisson random vectors ( Y 1 ,…, Y d ),…”
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Simulating High-Dimensional Multivariate Data using the bigsimr R Package by Schissler, A. Grant, Bedrick, Edward J, Knudson, Alexander D, Kozubowski, Tomasz J, Nguyen, Tin, Panorska, Anna K, Petereit, Juli, Piegorsch, Walter W, Tran, Duc

“…It is critical to accurately simulate data when employing Monte Carlo techniques and evaluating statistical methodology. Measurements are often correlated and…”
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