Search Results - "Schirris, Tom"

Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment by Frambach, Sanne J C M, de Haas, Ria, Smeitink, Jan A M, Rongen, Gerard A, Russel, Frans G M, Schirris, Tom J J

“…Atherosclerosis is a leading cause of cardiovascular disease worldwide, and hypercholesterolemia is a major risk factor. Preventive treatments mainly focus on…”
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Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition by Schirris, Tom J.J., Renkema, G. Herma, Ritschel, Tina, Voermans, Nicol C., Bilos, Albert, van Engelen, Baziel G.M., Brandt, Ulrich, Koopman, Werner J.H., Beyrath, Julien D., Rodenburg, Richard J., Willems, Peter H.G.M., Smeitink, Jan A.M., Russel, Frans G.M.

“…Cholesterol-lowering statins effectively reduce the risk of major cardiovascular events. Myopathy is the most important adverse effect, but its underlying…”
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Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention by van de Wal, Melissa A E, Adjobo-Hermans, Merel J W, Keijer, Jaap, Schirris, Tom J J, Homberg, Judith R, Wieckowski, Mariusz R, Grefte, Sander, van Schothorst, Evert M, van Karnebeek, Clara, Quintana, Albert, Koopman, Werner J H

“…Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative phosphorylation (OXPHOS). Dysfunction of these organelles is…”
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Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia by Vriend, Jelle, Peters, Janny G.P., Nieskens, Tom T.G., Škovroňová, Renata, Blaimschein, Nina, Schmidts, Miriam, Roepman, Ronald, Schirris, Tom J.J., Russel, Frans G.M., Masereeuw, Rosalinde, Wilmer, Martijn J.

“…Kidney disease modeling and assessment of drug-induced kidney injury can be advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo…”
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Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins by Hoogstraten, Charlotte A., Schirris, Tom J. J., Russel, Frans G. M.

“…A disturbed mitochondrial function contributes to the pathology of many common diseases. These organelles are therefore important therapeutic targets. On the…”
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Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux by Liemburg-Apers, Dania C., Schirris, Tom J.J., Russel, Frans G.M., Willems, Peter H.G.M., Koopman, Werner J.H.

“…ATP can be produced in the cytosol by glycolytic conversion of glucose (GLC) into pyruvate. The latter can be metabolized into lactate, which is released by…”
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Impact of tyrosine kinase inhibitors on glucose control and insulin regulation in patients with chronic myeloid leukemia by Janssen, Lando, Hopman, Maria T E, Swaans, Greetje J A, Allard, Neeltje A E, Boss, Marti, Lobeek, Daphne, Gotthardt, Martin, Schirris, Tom J J, Blijlevens, Nicole M A, Timmers, Silvie

“…Treatment with tyrosine kinase inhibitors (TKIs), especially nilotinib, often results in hyperglycemia, which may further increase cardiovascular disease risk…”
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Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells by van der Pol, Karel H, Koenderink, Jan, van den Heuvel, Jeroen J M W, van den Broek, Petra, Peters, Janny, van Bunningen, Imke D W, Pertijs, Jeanne, Russel, Frans G M, Koldenhof, Jim, Morshuis, Wim J, van Drongelen, Joris, Schirris, Tom J J, van der Meer, Andries, Rongen, Gerard A

“…Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of…”
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Mitochondrial complex III activity: from invasive muscle biopsies to patient-friendly buccal swab analysis by Somers, Tim, Allard, Neeltje A. E., Siddiqi, Sailay, Janssen, Margit C. M., Hopman, Maria T. E., Morshuis, Wim J., Russel, Frans G. M., Timmers, Silvie, Schirris, Tom J. J.

“…Drug-induced mitochondrial dysfunction is a common adverse effect, particularly in case of statins—the most prescribed drugs worldwide. These drugs have been…”
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Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency by Frambach, Sanne J.C.M., de Haas, Ria, Smeitink, Jan A.M., Russel, Frans G.M., Schirris, Tom J.J.

“…Mitochondrial complex I (CI), the first multiprotein enzyme complex of the oxidative phosphorylation system, plays a crucial role in cellular energy…”
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Statin Lactonization by Uridine 5′-Diphospho-glucuronosyltransferases (UGTs) by Schirris, Tom J. J, Ritschel, Tina, Bilos, Albert, Smeitink, Jan A. M, Russel, Frans G. M

“…Statins are cholesterol-lowering drugs that have proven to be effective in lowering the risk of major cardiovascular events. Although well tolerated,…”
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Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification by Somers, Tim, Siddiqi, Sailay, Maas, Renee G. C., Sluijter, Joost P. G., Buikema, Jan W., van den Broek, Petra H. H., Meuwissen, Tanne J., Morshuis, Wim J., Russel, Frans G. M., Schirris, Tom J. J.

“…Statins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting cholesterol synthesis. These effects are primarily beneficial for…”
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Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity by Hoogstraten, Charlotte A, Lyon, Jonathan J, Smeitink, Jan A M, Russel, Frans G M, Schirris, Tom J J

“…An increasing number of commonly prescribed drugs are known to interfere with mitochondrial function, which is associated with almost half of all Food and Drug…”
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Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism by Allard, Neeltje A E, Schirris, Tom J J, Verheggen, Rebecca J, Russel, Frans G M, Rodenburg, Richard J, Smeitink, Jan A M, Thompson, Paul D, Hopman, Maria T E, Timmers, Silvie

“…Statin myopathy is linked to disturbances in mitochondrial function and exercise intolerance. To determine whether differences exist in exercise performance,…”
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Safety of drug use in patients with a primary mitochondrial disease: An international Delphi‐based consensus by De Vries, Maaike C., Brown, David A., Allen, Mitchell E., Bindoff, Laurence, Gorman, Gráinne S., Karaa, Amel, Keshavan, Nandaki, Lamperti, Costanza, McFarland, Robert, Ng, Yi Shiau, O'Callaghan, Mar, Pitceathly, Robert D. S., Rahman, Shamima, Russel, Frans G. M., Varhaug, Kristin N., Schirris, Tom J. J., Mancuso, Michelangelo

“…Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in…”
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Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells by Hoogstraten, Charlotte A., Jacobs, Maaike M. E., de Boer, Guido, van de Wal, Melissa A. E., Koopman, Werner J. H., Smeitink, Jan A. M., Russel, Frans G. M., Schirris, Tom J. J.

“…Mitochondrial dysfunction is pivotal in drug-induced acute kidney injury (AKI), but the underlying mechanisms remain largely unknown. Transport proteins…”
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Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells by Vriend, Jelle, Hoogstraten, Charlotte A, Venrooij, Kevin R, van den Berge, Bartholomeus T, Govers, Larissa P, van Rooij, Arno, Huigen, Marleen C D G, Schirris, Tom J J, Russel, Frans G M, Masereeuw, Rosalinde, Wilmer, Martijn J

“…Organic anion transporters (OATs) 1 and 3 are, besides being uptake transporters, key in several cellular metabolic pathways. The underlying mechanisms are…”
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Effect of statins on mitochondrial function and contractile force in human skeletal and cardiac muscle by Somers, Tim, Siddiqi, Sailay, Janssen, Margit C.M., Morshuis, Wim J., Maas, Renee G.C., Buikema, Jan W., van den Broek, Petra H.H., Schirris, Tom J.J., Russel, Frans G.M.

“…The success of statin therapy in reducing cardiovascular morbidity and mortality is contrasted by the skeletal muscle complaints, which often leads to…”
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Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells by Westerink, Walter M.A., Schirris, Tom J.J., Horbach, G. Jean, Schoonen, Willem G.E.J.

“…► In drug development assays for the early detection of genotoxicity are needed. ► Two high content screening (HCS) micronucleus assays were developed and…”
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Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity by Weigand, Karl M., Schirris, Tom J.J., Houweling, Megan, van den Heuvel, Jeroen J.M.W., Koenderink, Jan B., Dankers, Anita C.A., Russel, Frans G.M., Greupink, Rick

“…Chronic kidney disease (CKD) is accompanied by accumulating levels of uremic solutes in the circulation. Changes in the size and composition of the bile acid…”
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