Search Results - "Schirmer, R H"

Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster by Kanzok, Stefan M., Fechner, Anke, Bauer, Holger, Ulschmid, Julia K., Müller, Hans-Michael, Botella-Munoz, José, Schneuwly, Stephan, Schirmer, R. Heiner, Becker, Katja

“…The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins…”
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Glutathione Reductase of the Malarial Parasite Plasmodium falciparum: Crystal Structure and Inhibitor Development by Sarma, G.N., Savvides, S.N., Becker, K., Schirmer, M., Schirmer, R.H., Karplus, P.A.

“…The malarial parasite Plasmodium falciparum is known to be sensitive to oxidative stress, and thus the antioxidant enzyme glutathione reductase (GR;…”
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The thioredoxin system of Plasmodium falciparum and other parasites by Rahlfs, S, Schirmer, R H, Becker, K

“…Antioxidant defence plays a crucial role in rapidly growing and multiplying organisms, including parasites and tumor cells. Apart from reactive oxygen species…”
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Glutathione--functions and metabolism in the malarial parasite Plasmodium falciparum by Becker, Katja, Rahlfs, Stefan, Nickel, Christine, Schirmer, R Heiner

“…When present as a trophozoite in human erythrocytes, the malarial parasite Plasmodium falciparum exhibits an intense glutathione metabolism. Glutathione plays…”
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A Prodrug Form of a Plasmodium falciparum Glutathione Reductase Inhibitor Conjugated with a 4-Anilinoquinoline by Davioud-Charvet, Elisabeth, Delarue, Sandrine, Biot, Christophe, Schwöbel, Babett, Boehme, Catharina C, Müssigbrodt, Andreas, Maes, Louis, Sergheraert, Christian, Grellier, Philippe, Schirmer, R. Heiner, Becker, Katja

“…Glutathione (GSH), which is known to guard Plasmodium falciparum from oxidative damage, may have an additional protective role by promoting heme catabolism. An…”
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Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue by Färber, P.M, Arscott, L.D, Williams, C.H, Becker, K, Schirmer, R.H

“…Plasmodium falciparum glutathione reductase (PfGR) has emerged as a drug target against tropical malaria. Here we report the expression of PfGR in Escherichia…”
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A hypothesis on the catalytic mechanism of the selenoenzyme thioredoxin reductase by Gromer, S, Wissing, J, Behne, D, Ashman, K, Schirmer, R H, Flohé, L, Becker, K

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Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor--a pilot study by Becker, K, Pons-Kühnemann, J, Fechner, A, Funk, M, Gromer, S, Gross, H-J, Grünert, A, Schirmer, R H

“…Kwashiorkor is a severe edematous form of malnutrition with high prevalence and lethality in many African countries, and repeatedly has been reported to be…”
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The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue by Kasozi, D M, Gromer, S, Adler, H, Zocher, K, Rahlfs, S, Wittlin, S, Fritz-Wolf, K, Schirmer, R H, Becker, Katja

“…The quorum sensor and signalling molecule pyocyanin (PYO) contributes significantly to the pathophysiology of Pseudomonas aeruginosa infections. Comparison to…”
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5-Substituted Tetrazoles as Bioisosteres of Carboxylic Acids. Bioisosterism and Mechanistic Studies on Glutathione Reductase Inhibitors as Antimalarials by Biot, Christophe, Bauer, Holger, Schirmer, R. Heiner, Davioud-Charvet, Elisabeth

“…Plasmodium parasites are exposed to elevated fluxes of reactive oxygen species during intraerythrocytic life. The most important antioxidative systems are…”
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Dinitrosyl-Dithiol-Iron Complexes, Nitric Oxide (NO) Carriers In Vivo, as Potent Inhibitors of Human Glutathione Reductase and Glutathione- S-Transferase by Keese, Michael A, Böse, Matthias, Mülsch, Alexander, Schirmer, R.Heiner, Becker, Katja

“…Human glutathione reductase (GR) and rat liver glutathione- S-transferases (GSTs) had been shown to be inhibited by the nitric oxide (NO) carrier…”
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The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited by Kanzok, S M, Schirmer, R H, Turbachova, I, Iozef, R, Becker, K

“…In most living cells, redox homeostasis is based both on the glutathione and the thioredoxin system. In the malaria parasite Plasmodium falciparum…”
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Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers by Becker, Katja, Savvides, Savvas N, Keese, Michael, Schirmer, R. Heiner, Karplus, P. Andrew

“…Nitric oxide (NO) is a pluripotent regulatory molecule, yet the molecular mechanisms by which it exerts its effects are largely unknown. Few physiologic target…”
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Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds by Gromer, S, Arscott, L D, Williams, Jr, C H, Schirmer, R H, Becker, K

“…Human thioredoxin reductase is a pyridine nucleotide-disulfide oxidoreductase closely related to glutathione reductase but differing from the latter in having…”
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Human Thioredoxin Reductase Is Efficiently Inhibited by (2,2‘:6‘,2‘ ‘-Terpyridine)platinum(II) Complexes. Possible Implications for a Novel Antitumor Strategy by Becker, Katja, Herold-Mende, Christel, Park, Jenny J, Lowe, Gordon, Schirmer, R. Heiner

“…Malignant neoplasms of the brain represent the second leading cause of cancer-related mortality in children under the age of 15. The prognosis of patients with…”
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A glutathione reductase-like flavoenzyme of the malaria parasite Plasmodium falciparum: structural considerations based on the DNA sequence by Becker, K, Müller, S, Keese, M A, Walter, R D, Schirmer, R H

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Comparative Structural Analysis of Oxidized and Reduced Thioredoxin from Drosophila melanogaster by Wahl, Markus C., Irmler, Angelika, Hecker, Beate, Schirmer, R. Heiner, Becker, Katja

“…Thioredoxins (Trx) participate in essential antioxidant and redox-regulatory processes via a pair of conserved cysteine residues. In dipteran insects like…”
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X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium falciparum by Fritz-Wolf, Karin, Becker, Andreas, Rahlfs, Stefan, Harwaldt, Petra, Schirmer, R. Heiner, Kabsch, Wolfgang, Becker, Katja

“…GSTs catalyze the conjugation of glutathione with a wide variety of hydrophobic compounds, generally resulting in nontoxic products that can be readily…”
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The structure of the flavoenzyme glutathione reductase by Schulz, G. E, Schirmer, R. H, Sachsenheimer, W, Pai, E. F

“…The three-dimensional structure of the dimeric flavoenzyme glutathione reductase from human erythrocytes has been elucidated by an X-ray diffraction analysis…”
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Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite by Savvides, Savvas N., Scheiwein, Michael, Böhme, Catharina C., Arteel, Gavin E., Karplus, P. Andrew, Becker, Katja, Schirmer, R. Heiner

“…As part of our studies on the nitric oxide-related pathology of cerebral malaria, we show that the antioxidative enzyme glutathione reductase (GR) is…”
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