Search Results - "Schipper, Pauline J"

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids by Gumbs, Stephanie B H, Berdenis van Berlekom, Amber, Kübler, Raphael, Schipper, Pauline J, Gharu, Lavina, Boks, Marco P, Ormel, Paul R, Wensing, Annemarie M J, de Witte, Lot D, Nijhuis, Monique

“…The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central…”
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Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance by Fun, Axel, Leitner, Thomas, Vandekerckhove, Linos, Däumer, Martin, Thielen, Alexander, Buchholz, Bernd, Hoepelman, Andy I M, Gisolf, Elizabeth H, Schipper, Pauline J, Wensing, Annemarie M J, Nijhuis, Monique

“…Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection…”
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HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat by Fun, Axel, van Maarseveen, Noortje M, Pokorná, Jana, Maas, Renée Em, Schipper, Pauline J, Konvalinka, Jan, Nijhuis, Monique

“…Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural…”
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Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity by van Maarseveen, Noortje M, Andersson, Dan, Lepšík, Martin, Fun, Axel, Schipper, Pauline J, de Jong, Dorien, Boucher, Charles A B, Nijhuis, Monique

“…Mutations in the substrate of HIV-1 protease, especially changes in the NC/p1 cleavage site, can directly contribute to protease inhibitor (PI) resistance and…”
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Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses by Gumbs, Stephanie B. H., Kübler, Raphael, Gharu, Lavina, Schipper, Pauline J., Borst, Anne L., Snijders, Gijsje J. L. J., Ormel, Paul R., van Berlekom, Amber Berdenis, Wensing, Annemarie M. J., de Witte, Lot D., Nijhuis, Monique

“…HIV persistence in the CNS despite antiretroviral therapy may cause neurological disorders and poses a critical challenge for HIV cure. Understanding the…”
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Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection by Connell, Bridgette J., Hermans, Lucas E., Wensing, Annemarie M. J., Schellens, Ingrid, Schipper, Pauline J., van Ham, Petra M., de Jong, Dorien T. C. M., Otto, Sigrid, Mathe, Tholakele, Moraba, Robert, Borghans, José A. M., Papathanasopoulos, Maria A., Kruize, Zita, Venter, Francois W. D., Kootstra, Neeltje A., Tempelman, Hugo, Tesselaar, Kiki, Nijhuis, Monique

“…HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected…”
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Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells by Gumbs, Stephanie B. H., Stam, Arjen J., Mudrikova, Tania, Schipper, Pauline J., Hoepelman, Andy I. M., van Ham, Petra M., Borst, Anne L., Hofstra, LMarije, Gharu, Lavina, van Wyk, Stephanie, Wilkinson, Eduan, de Witte, Lot D., Wensing, Annemarie M. J., Nijhuis, Monique

“…Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in people living…”
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An inkjet-printed polysaccharide matrix for on-chip sample preparation in point-of-care cell counting chambers by Zhang, Xichen, Wasserberg, Dorothee, Breukers, Christian, Connell, Bridgette J, Schipper, Pauline J, van Dalum, Joost, Baeten, Ellen, van den Blink, Dorine, Bloem, Andries C, Nijhuis, Monique, Wensing, Annemarie M. J, Terstappen, Leon W. M. M, Beck, Markus

“…On-chip sample preparation in self-contained microfluidic devices is a key element to realize simple, low-cost, yet reliable in vitro diagnostics that can be…”
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Mutation Q95K enhances N155H-mediated integrase inhibitor resistance and improves viral replication capacity by Fun, Axel, Van Baelen, Kurt, van Lelyveld, Steven F. L., Schipper, Pauline J., Stuyver, Lieven J., Wensing, Annemarie M. J., Nijhuis, Monique

“…Objectives The genetic barrier to development of raltegravir resistance is considered to be low, requiring at least one primary integrase mutation: Y143C,…”
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Enhanced severity of virus associated lower respiratory tract disease in asthma patients may not be associated with delayed viral clearance and increased viral load in the upper respiratory tract by van Elden, Leontine J.R, Sachs, Alfred P.E, van Loon, Anton M, Haarman, Monique, van de Vijver, David A, Kimman, Tjeerd G, Zuithoff, Peter, Schipper, Pauline J, Verheij, Theo J.M, Nijhuis, Monique

“…Abstract Background Viral respiratory infections, particularly human rhinovirus (HRV) infections, are the most common cause of asthma exacerbation. HRV…”
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