Search Results - "Schipper, David L."

A network-centric approach to drugging TNF-induced NF-κB signaling by Pabon, Nicolas A., Zhang, Qiuhong, Cruz, J. Agustin, Schipper, David L., Camacho, Carlos J., Lee, Robin E. C.

“…Target-centric drug development strategies prioritize single-target potency in vitro and do not account for connectivity and multi-target effects within a…”
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A System for Analog Control of Cell Culture Dynamics to Reveal Capabilities of Signaling Networks by Mokashi, Chaitanya S., Schipper, David L., Qasaimeh, Mohammad A., Lee, Robin E.C.

“…Cellular microenvironments are dynamic. When exposed to extracellular cues, such as changing concentrations of inflammatory cytokines, cells activate signaling…”
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A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB by Cruz, J. Agustin, Mokashi, Chaitanya S., Kowalczyk, Gabriel J., Guo, Yue, Zhang, Qiuhong, Gupta, Sanjana, Schipper, David L., Smeal, Steven W., Lee, Robin E. C.

“…A variable-gain stochastic pooling motif mediates robust and parsimonious information transmission from the extracellular milieu. A myriad of inflammatory…”
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