Search Results - "Schins, Roel P.F"

Oxidant Generation and Toxicity of Size-Fractionated Ambient Particles in Human Lung Epithelial Cells by Wessels, Anton, Birmili, Wolfram, Albrecht, Catrin, Hellack, Bryan, Jermann, Erich, Wick, Gabriele, Harrison, Roy M, Schins, Roel P.F

“…Exposure to ambient particulate matter (PM) is associated with respiratory and cardiovascular disease and lung cancer. In this study, we used size fractionated…”
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Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents by Schins, Roel P.F, Lightbody, Janet H, Borm, Paul J.A, Shi, Tingming, Donaldson, Ken, Stone, Vicki

“…There is conflicting evidence in the literature as to the predominant mechanism and also the compositional element(s) that drives the pulmonary inflammatory…”
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Saharan dust induces the lung disease-related cytokines granulocyte–macrophage colony-stimulating factor and granulocyte colony-stimulating factor by Bredeck, Gerrit, Dobner, Jochen, Rossi, Andrea, Schins, Roel P.F.

“…[Display omitted] •RNA sequencing was applied to an alveolar air–liquid interface co-culture model.•Different inflammatory mediators were activated by Saharan…”
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Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge by Stone, Vicki, Miller, Mark R, Clift, Martin J D, Elder, Alison, Mills, Nicholas L, Møller, Peter, Schins, Roel P F, Vogel, Ulla, Kreyling, Wolfgang G, Alstrup Jensen, Keld, Kuhlbusch, Thomas A J, Schwarze, Per E, Hoet, Peter, Pietroiusti, Antonio, De Vizcaya-Ruiz, Andrea, Baeza-Squiban, Armelle, Teixeira, João Paulo, Tran, C Lang, Cassee, Flemming R

“…A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is…”
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Inhalable Saharan dust induces oxidative stress, NLRP3 inflammasome activation, and inflammatory cytokine release by Bredeck, Gerrit, Busch, Mathias, Rossi, Andrea, Stahlmecke, Burkhard, Fomba, Khanneh Wadinga, Herrmann, Hartmut, Schins, Roel P.F.

“…[Display omitted] •Microbial components contribute to the pro-inflammatory potential of Saharan dust.•Saharan dust induces oxidative stress and…”
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Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models by Kämpfer, Angela A. M., Busch, Mathias, Büttner, Veronika, Bredeck, Gerrit, Stahlmecke, Burkhard, Hellack, Bryan, Masson, Isabelle, Sofranko, Adriana, Albrecht, Catrin, Schins, Roel P. F.

“…With the rising interest in the effects of orally ingested engineered nanomaterials (ENMs), much effort is undertaken to develop and advance intestinal in…”
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Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required? by Llewellyn, Samantha V., Kämpfer, Angela, Keller, Johannes G., Vilsmeier, Klaus, Büttner, Veronika, Ag Seleci, Didem, Schins, Roel P. F., Doak, Shareen H., Wohlleben, Wendel

“…Would an engineered nanomaterial (ENM) still have the same identity once it reaches a secondary target tissue after a journey through several physiological…”
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Inhaled particles and lung cancer. Part A: Mechanisms by Knaapen, Ad M., Borm, Paul J.A., Albrecht, Catrin, Schins, Roel P.F.

“…Both occupational and environmental exposure to particles is associated with an increased risk of lung cancer. Particles are thought to impact on genotoxicity…”
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Particle lung deposited surface area (LDSAal) size distributions in different urban environments and geographical regions: Towards understanding of the PM2.5 dose–response by Lepistö, Teemu, Lintusaari, Henna, Oudin, Anna, Barreira, Luis M.F., Niemi, Jarkko V., Karjalainen, Panu, Salo, Laura, Silvonen, Ville, Markkula, Lassi, Hoivala, Jussi, Marjanen, Petteri, Martikainen, Sampsa, Aurela, Minna, Reyes, Felipe Reyes, Oyola, Pedro, Kuuluvainen, Heino, Manninen, Hanna E., Schins, Roel P.F., Vojtisek-Lom, Michal, Ondracek, Jakub, Topinka, Jan, Timonen, Hilkka, Jalava, Pasi, Saarikoski, Sanna, Rönkkö, Topi

“…[Display omitted] •Characteristic LDSAal size distributions depending on urban environment and country.•Ultrafine particles major contributor on LDSAal in…”
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Inhaled particles and lung cancer, part B: Paradigms and risk assessment by Borm, Paul J.A., Schins, Roel P.F., Albrecht, Catrin

“…Poorly soluble particles of low toxicity (PSP), such as CB, TiO2 and coal mine dust, have been demonstrated to cause lung cancer in rodents, being most…”
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Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells by Gerloff, Kirsten, Pereira, Dora I.A., Faria, Nuno, Boots, Agnes W., Kolling, Julia, Förster, Irmgard, Albrecht, Catrin, Powell, Jonathan J., Schins, Roel P.F.

“…Abstract Novel aspects of engineered nanoparticles offer many advantages for optimising food products and packaging. However, their potential hazards in the…”
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Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles by van Berlo, Damien, Wessels, Anton, Boots, Agnes W., Wilhelmi, Verena, Scherbart, Agnes M., Gerloff, Kirsten, van Schooten, Frederik J., Albrecht, Catrin, Schins, Roel P.F.

“…The carcinogenicity of respirable quartz is considered to be driven by reactive oxygen species (ROS) generation in association with chronic inflammation. The…”
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Transition metals in personal samples of PM2.5 and oxidative stress in human volunteers by SØRENSEN, Mette, SCHINS, Roel P. F, HERTEL, Ole, LOFT, Steffen

“…Ambient particulate matter (PM) has been associated with increased risk of lung cancer. One proposed mechanism is that PM induces oxidative stress mediated by…”
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Oxidative potential of particulate matter at a German motorway by Hellack, Bryan, Quass, Ulrich, Nickel, Carmen, Wick, Gabriele, Schins, Roel P F, Kuhlbusch, Thomas A J

“…Ambient particulate matter (PM10) was sampled alongside a motorway in North-Rhine Westphalia, Germany, during a one-year period. In sum, 120 PM10 samples on…”
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Elemental composition and oxidative properties of PM₂.₅ in Estonia in relation to origin of air masses — results from the ECRHS II in Tartu by Orru, Hans, Kimmel, Veljo, Kikas, Ülle, Soon, Argo, Künzli, Nino, Schins, Roel P.F, Borm, Paul J.A, Forsberg, Bertil

“…Fine particulate matter (PM₂.₅) was sampled at an urban background site in Tartu, Estonia over one-year period during the ECRHS II study. The elemental…”
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The surface area rather than the surface coating determines the acute inflammatory response after instillation of fine and ultrafine TiO2 in the rat by Höhr, Doris, Steinfartz, Yvonne, Schins, Roel P.F., Knaapen, Ad M., Martra, Gianmario, Fubini, Bice, Borm, Paul J.A.

“…Alterations in the hydrophobic status of particle surfaces have been suggested to modify the toxic properties of ultrafine TiO2. We investigated the acute…”
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DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation by Knaapen, Ad M., Albrecht, Catrin, Becker, Andrea, Höhr, Doris, Winzer, Astrid, Haenen, Guido R., Borm, Paul J.A., Schins, Roel P.F.

“…Respirable quartz has been classified as a human lung carcinogen (IARC, 1997). However, the mechanisms involved in quartz-induced carcinogenesis remain…”
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Neutrophils cause oxidative DNA damage in alveolar epithelial cells by Knaapen, Ad M, Seiler, Frank, Schilderman, Pauline A.E.L, Nehls, Peter, Bruch, Joachim, Schins, Roel P.F, Borm, Paul J.A

“…Inflammation has been recognized as a contributing factor in the pathogenesis of some cancers. In the lung, inflammation is characterized by an influx of…”
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Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase by Knaapen, Ad M., Schins, Roel P.F., Borm, Paul J.A., van Schooten, Frederik J.

“…Chronic inhalation of environmental particles is associated with pulmonary carcinogenesis. Although the mechanism has not yet been fully elucidated, influx of…”
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In vitro genotoxicity assessment of commercial quartz flours in comparison to standard DQ12 quartz by Cakmak, Gonca D., Schins, Roel P.F., Shi, Tingming, Fenoglio, Ivana, Fubini, Bice, Borm, Paul J.A.

“…Crystalline silica has been classified as a human carcinogen, but there is still considerable debate on its variable fibrogenic and carcinogenic potential. We…”
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