Search Results - "Schinkel, A."

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity by Filipski, K K, Mathijssen, R H, Mikkelsen, T S, Schinkel, A H, Sparreboom, A

“…Cisplatin is one of the most widely used anticancer agents for the treatment of solid tumors. The clinical use of cisplatin is associated with dose‐limiting…”
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Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response by Bacq, A, Balasse, L, Biala, G, Guiard, B, Gardier, A M, Schinkel, A, Louis, F, Vialou, V, Martres, M-P, Chevarin, C, Hamon, M, Giros, B, Gautron, S

“…High-affinity transporters for norepinephrine (NE) and serotonin (5-HT), which ensure neurotransmitter clearance at the synapse, are the principal targets of…”
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Hepatocyte Hopping of OATP1B Substrates Contributes to Efficient Hepatic Detoxification by Iusuf, D, van de Steeg, E, Schinkel, A H

“…Human organic anion–transporting polypeptides (OATP)1B1 and OATP1B3 are major drug uptake transporters present in the basolateral (sinusoidal) membrane of…”
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Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation by Hendrikx, J J M A, Lagas, J S, Wagenaar, E, Rosing, H, Schellens, J H M, Beijnen, J H, Schinkel, A H

“…Background: The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug…”
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Effects of cytochrome P450 3A (CYP3A) and the drug transporters P‐glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir by van Waterschoot, RAB, ter Heine, R, Wagenaar, E, van der Kruijssen, CMM, Rooswinkel, RW, Huitema, ADR, Beijnen, JH, Schinkel, AH

“…Background and purpose:  Lopinavir is extensively metabolized by cytochrome P450 3A (CYP3A) and is considered to be a substrate for the drug transporters ABCB1…”
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Effect of body surface area and gender on wall thickness thresholds in hypertrophic cardiomyopathy by Huurman, R., Schinkel, A. F. L, van der Velde, N., Bowen, D. J., Menting, M. E., van den Bosch, A. E., van Slegtenhorst, M., Hirsch, A., Michels, M.

“…Background Family screening for hypertrophic cardiomyopathy (HCM) is based on genetic testing and clinical evaluation (maximal left ventricular wall thickness…”
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Prognosis of patients with ischaemic cardiomyopathy after coronary revascularisation: relation to viability and improvement in left ventricular ejection fraction by Rizzello, V, Poldermans, D, Biagini, E, Schinkel, A F L, Boersma, E, Boccanelli, A, Marwick, T, Roelandt, J R T C, Bax, J J

“…In patients with ischaemic cardiomyopathy and viable myocardium, left ventricular ejection fraction (LVEF) does not always improve after revascularisation…”
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Quantitative contrast-enhanced ultrasound of intraplaque neovascularization in patients with carotid atherosclerosis by van den Oord, S C H, Akkus, Z, Bosch, J G, Hoogi, A, ten Kate, G L, Renaud, G, Sijbrands, E J G, Verhagen, H J, van der Lugt, A, Adam, D, de Jong, N, van der Steen, A F W, Schinkel, A F L

“…Intraplaque neovascularization (IPN) is an increasingly studied marker of the vulnerable atherosclerotic plaque, and contrast-enhanced ultrasound (CEUS) is an…”
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P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387 by Durmus, S., Xu, N., Sparidans, R.W., Wagenaar, E., Beijnen, J.H., Schinkel, A.H.

“…CYT387 is an orally bioavailable, small molecule inhibitor of Janus family of tyrosine kinases (JAK) 1 and 2. It is currently undergoing Phase I/II clinical…”
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Development and validation of a UPLC-MS/MS method with a broad linear dynamic range for the quantification of morphine, morphine-3-glucuronide and morphine-6-glucuronide in mouse plasma and tissue homogenates by Heydari, P., Martins, M.L.F., Rosing, H., Hillebrand, M.J.X., Gebretensae, A., Schinkel, A.H., Beijnen, J.H.

“…•Validated LC-MS/MS method for quantification of morphine and its major metabolites.•Concurrent analysis of morphine, morphine-3-glucuronide, and…”
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Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes by van Velzen, H. G., Schinkel, A. F. L., van Grootel, R. W. J., van Slegtenhorst, M. A., van der Velden, J., Strachinaru, M., Michels, M.

“…Background Previous studies have reported that global longitudinal strain (GLS) is reduced in patients with hypertrophic cardiomyopathy (HCM) while left…”
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Cognitive impairment in tuberous sclerosis complex is a multifactorial condition by JANSEN, F. E, VINCKEN, K. L, VAN HUFFELEN, A. C, VAN NIEUWENHUIZEN, O, ALGRA, A, ANBEEK, P, BRAAMS, O, NELLIST, M, ZONNENBERG, B. A, JENNEKENS-SCHINKEL, A, VAN DEN OUWELAND, A, HALLEY, D

“…In patients with tuberous sclerosis complex (TSC), associations between tuber number, infantile spasms, and cognitive impairment have been proposed. We…”
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Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study by Tibben, M.M., Huijberts, S., Li, W., Schinkel, A.H., Gebretensae, A., Rosing, H., Beijnen, J.H.

“…•First reported quantitative assay for the determination of galunisertib in human plasma.•Fast and elegant HPLC-MS/MS method for quantification of galunisertib…”
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Ground reaction force patterns represent the level of training by Ertelt, T, Schinkel, A K

“…Hopping dependent on speed causes different characteristics of ground reaction force pattern. Strongly set training-specific stimuli equally induce a…”
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Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry by Teunissen, S.F., Jager, N.G.L., Rosing, H., Schinkel, A.H., Schellens, J.H.M., Beijnen, J.H.

“…A sensitive bioanalytical assay for the quantitative determination of tamoxifen and five of its phase I metabolites (N-desmethyltamoxifen,…”
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Noninvasive evaluation of ischaemic heart disease: myocardial perfusion imaging or stress echocardiography? by Schinkel, A.F.L, Bax, J.J, Geleijnse, M.L, Boersma, E, Elhendy, A, Roelandt, J.R.T.C, Poldermans, D

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ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation by Durmus, S., van der Valk, M., Teunissen, S. F., Song, J. Y., Wagenaar, E., Beijnen, J. H., Schinkel, A. H.

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is an abundant dietary carcinogen, formed during high-temperature cooking of meat. In this study, we…”
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Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling by Couroussé, T, Bacq, A, Belzung, C, Guiard, B, Balasse, L, Louis, F, Le Guisquet, A-M, Gardier, A M, Schinkel, A H, Giros, B, Gautron, S

“…Interactions between genetic and environmental factors, like exposure to stress, have an important role in the pathogenesis of mood-related psychiatric…”
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Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review by Teunissen, S.F., Rosing, H., Schinkel, A.H., Schellens, J.H.M., Beijnen, J.H.

“…The selective estrogen receptor modulator tamoxifen is used in the treatment of early and advanced breast cancer and in selected cases for breast cancer…”
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Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry by Hendrikx, J. J. M. A., Dubbelman, A. C., Rosing, H., Schinkel, A. H., Schellens, J. H. M., Beijnen, J. H.

“…RATIONALE During drug development accurate quantification of metabolites in biological samples using mass spectrometry is often hampered by the lack of…”
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