Search Results - "Schini‐Kerth, Valérie B."

Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy by León-González, Antonio J., Auger, Cyril, Schini-Kerth, Valérie B.

“…[Display omitted] Reactive oxygen species (ROS) play a major role in carcinogenesis: pro-oxidant agents like tobacco smoke, asbestos or N-nitrosamines, are…”
Get full text

Betanin-A food colorant with biological activity by Esatbeyoglu, Tuba, Wagner, Anika E., Schini-Kerth, Valérie B., Rimbach, Gerald

“…Betalains are water‐soluble nitrogen‐containing pigments that are subdivided in red‐violet betacyanins and yellow‐orange betaxanthins. Due to glycosylation and…”
Get full text

Angiotensin II‐induced redox‐sensitive SGLT1 and 2 expression promotes high glucose‐induced endothelial cell senescence by Khemais‐Benkhiat, Sonia, Belcastro, Eugenia, Idris‐Khodja, Noureddine, Park, Sin‐Hee, Amoura, Lamia, Abbas, Malak, Auger, Cyril, Kessler, Laurence, Mayoux, Eric, Toti, Florence, Schini‐Kerth, Valérie B.

“…High glucose (HG)‐induced endothelial senescence and dysfunction contribute to the increased cardiovascular risk in diabetes. Empagliflozin, a selective sodium…”
Get full text

Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium by Oak, Min-Ho, Auger, Cyril, Belcastro, Eugenia, Park, Sin-Hee, Lee, Hyun-Ho, Schini-Kerth, Valérie B.

“…Epidemiological studies have indicated that regular intake of polyphenol-rich diets such as red wine and tea, are associated with a reduced risk of…”
Get full text

Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle-stimulated endothelial senescence and dysfunction: protective effect of gliflozins by Park, Sin-Hee, Belcastro, Eugenia, Hasan, Hira, Matsushita, Kensuke, Marchandot, Benjamin, Abbas, Malak, Toti, Florence, Auger, Cyril, Jesel, Laurence, Ohlmann, Patrick, Morel, Olivier, Schini-Kerth, Valérie B

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduced cardiovascular risk in type 2 diabetes patients independently of glycemic control. Although…”
Get full text

Molecular mechanisms of the cardiovascular protective effects of polyphenols by Andriantsitohaina, Ramaroson, Auger, Cyril, Chataigneau, Thierry, Étienne-Selloum, Nelly, Li, Huige, Martínez, M. Carmen, Schini-Kerth, Valérie B., Laher, Ismail

“…Epidemiological studies have reported a greater reduction in cardiovascular risk and metabolic disorders associated with diets rich in polyphenols. The…”
Get full text

Effects of polystyrene nanoplastics on endothelium senescence and its underlying mechanism by Shiwakoti, Saugat, Ko, Ju-Young, Gong, Dalseong, Dhakal, Bikalpa, Lee, Jeong-Hye, Adhikari, Radhika, Gwak, Yeonhyang, Park, Sin-Hee, Jun Choi, Ik, Schini-Kerth, Valérie B., Kang, Ki-Woon, Oak, Min-Ho

“…Global plastic use has increased rapidly, and environmental pollution associated with nanoplastics (NPs) has been a growing concern recently. However, the…”
Get full text

Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat by Park, Sin-Hee, Farooq, Muhammad Akmal, Gaertner, Sébastien, Bruckert, Christophe, Qureshi, Abdul Wahid, Lee, Hyun-Ho, Benrahla, Djamel, Pollet, Brigitte, Stephan, Dominique, Ohlmann, Patrick, Lessinger, Jean-Marc, Mayoux, Eric, Auger, Cyril, Morel, Olivier, Schini-Kerth, Valérie B

“…Empagliflozin (empa), a selective sodium-glucose cotransporter (SGLT)2 inhibitor, reduced cardiovascular mortality and hospitalization for heart failure in…”
Get full text

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases by da Silva, Tays A. F., Schini-Kerth, Valérie B., Medeiros, Isac Almeida de, de Menezes, Geovânia Maria Sales, Alves, Rayanne Maira Felix Ribeiro, de Azevedo, Fátima de L. A. A., de Oliveira, Júlio César Pinheiro Lúcio, de Lima Silva, Sonaly, Dantas, Sabine Helena, de Almeida Rezende, Mathania Silva, Almeida, Arthur José Pontes Oliveira de, dos Santos, Pablo Ferreira

“…The global population above 60 years has been growing exponentially in the last decades, which is accompanied by an increase in the prevalence of age-related…”
Get full text

Significance of neutrophil microparticles in ischaemia‐reperfusion: Pro‐inflammatory effectors of endothelial senescence and vascular dysfunction by El Habhab, Ali, Altamimy, Raed, Abbas, Malak, Kassem, Mohamad, Amoura, Lamia, Qureshi, Abdul Wahid, El Itawi, Hanine, Kreutter, Guillaume, Khemais‐Benkhiat, Sonia, Zobairi, Fatiha, Schini‐Kerth, Valérie B., Kessler, Laurence, Toti, Florence

“…Endothelial senescence is an emerging cause of vascular dysfunction. Because microparticles are effectors of endothelial inflammation and vascular injury after…”
Get full text

Probiotics (VSL#3) prevent endothelial dysfunction in rats with portal hypertension: role of the angiotensin system by Rashid, Sherzad K, Idris-Khodja, Noureddine, Khodja, Noureddine Idris, Auger, Cyril, Alhosin, Mahmoud, Boehm, Nelly, Oswald-Mammosser, Monique, Schini-Kerth, Valérie B

“…Portal hypertension characterized by generalized vasodilatation with endothelial dysfunction affecting nitric oxide (NO) and endothelium-dependent…”
Get full text

SGLT2 inhibition ameliorates nano plastics-induced premature endothelial senescence and dysfunction by Dhakal, Bikalpa, Shiwakoti, Saugat, Park, Eun-Young, Kang, Ki-Woon, Schini-Kerth, Valérie B., Park, Sun-Hwa, Ji, Hye-Young, Park, Joon Seok, Ko, Ju-Young, Oak, Min-Ho

“…Nano plastics (NPs) have been a significant threat to human health and are known to cause premature endothelial senescence. Endothelial senescence is…”
Get full text

Redox-sensitive induction of Src/PI3-kinase/Akt and MAPKs pathways activate eNOS in response to EPA:DHA 6:1 by Zgheel, Faraj, Alhosin, Mahmoud, Rashid, Sherzad, Burban, Mélanie, Auger, Cyril, Schini-Kerth, Valérie B

“…Omega-3 fatty acid products containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have vasoprotective effects, in part, by stimulating the…”
Get full text

Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial by Zhou, Xiaoxin, Lin, Xiaoqian, Yu, Jing, Yang, Yi, Muzammel, Hira, Amissi, Said, Schini-Kerth, Valérie B, Lei, Xun, Jose, Pedro A, Yang, Jian, Shi, Dan

“…Time-restricted eating (TRE), a popular form of intermittent fasting, has shown benefits for improving metabolic diseases and cardiometabolic health. However,…”
Get full text

Replicative senescence promotes prothrombotic responses in endothelial cells: Role of NADPH oxidase- and cyclooxygenase-derived oxidative stress by Silva, Grazielle Caroline, Abbas, Malak, Khemais-Benkhiat, Sonia, Burban, Melanie, Ribeiro, Thais Porto, Toti, Florence, Idris-Khodja, Noureddine, Côrtes, Steyner F., Schini-Kerth, Valérie B.

“…Endothelial senescence has been suggested to promote endothelial dysfunction in age-related vascular disorders. This study evaluated the prothrombotic…”
Get full text

Polyphenol-rich Aronia melanocarpa juice sustains eNOS activation through phosphorylation and expression via redox-sensitive pathways in endothelial cells by Kim, Jong Hun, Choi, Min Sik, Auger, Cyril, Lee, Ki Won, Schini-Kerth, Valérie B.

“…A sustained formation of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) is crucial to safeguard the vascular system against the development of…”
Get full text

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1 by Alhosin, Mahmoud, Abusnina, Abdurazzag, Achour, Mayada, Sharif, Tanveer, Muller, Christian, Peluso, Jean, Chataigneau, Thierry, Lugnier, Claire, Schini-Kerth, Valérie B., Bronner, Christian, Fuhrmann, Guy

“…The salvage anti-tumoral pathway which implicates the p53-related p73 gene is not yet fully characterized. We therefore attempted to identify the up- and…”
Get full text

Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system by Idris Khodja, Noureddine, Chataigneau, Thierry, Auger, Cyril, Schini-Kerth, Valérie B

“…Aging is characterized by the development of an endothelial dysfunction, which affects both the nitric oxide (NO)- and the endothelium-derived hyperpolarizing…”
Get full text

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1 by Achour, Mayada, Mousli, Marc, Alhosin, Mahmoud, Ibrahim, Abdulkhaleg, Peluso, Jean, Muller, Christian D., Schini-Kerth, Valérie B., Hamiche, Ali, Dhe-Paganon, Sirano, Bronner, Christian

“…► EGCG down-regulated UHRF1 and DNMT1 expressions in jurkat cells. ► Down-regulation of UHRF1 enhanced expression of p16INK4A and p73. ► UHRF1 over-expression…”
Get full text

Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF by Schini-Kerth, Valérie B., Auger, Cyril, Kim, Jong-Hun, Étienne-Selloum, Nelly, Chataigneau, Thierry

“…Numerous studies indicate that regular intake of polyphenol-rich beverages (red wine and tea) and foods (chocolate, fruit, and vegetables) is associated with a…”
Get full text