Search Results - "Schindeler, A."

Cell-scaffold interactions in the bone tissue engineering triad by Murphy, Ciara M, O'Brien, Fergal J, Little, David G, Schindeler, Aaron

“…Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies…”
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Diagnosis of Recurrent Fracture in a Pediatric Cohort by Fiscaletti, M., Coorey, C. P., Biggin, A., Briody, J., Little, D. G., Schindeler, A., Munns, C. F.

“…Significant fracture history in children is defined as having at least one vertebral fracture, at least 2 fractures by age 10, or at least 3 fractures by age…”
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Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone by Shahen, V. A., Schindeler, A., Rybchyn, M. S., Girgis, C. M., Mulholland, B., Mason, R. S., Levinger, I., Brennan-Speranza, T. C.

“…Patients with type 2 diabetes mellitus (T2DM) experience a higher risk of fractures despite paradoxically exhibiting normal to high bone mineral density (BMD)…”
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Mechanical Load Increases in Bone Formation via a Sclerostin‐Independent Pathway by Morse, Alyson, McDonald, Michelle Maree, Kelly, Natalie H, Melville, Katherine M, Schindeler, Aaron, Kramer, Ina, Kneissel, Michaela, van der Meulen, Marjolein CH, Little, David Graham

“…ABSTRACT Sclerostin, encoded by the Sost gene, is an important negative regulator of bone formation that has been proposed to have a key role in regulating the…”
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Induction of periosteal bone formation by intraosseous BMP-2 injection in a mouse model of osteogenesis imperfecta by Cheng, T. L., Cantrill, L. C., Schindeler, A., Little, D. G.

“…Abstract Purpose Surgical interventions are routinely performed on children with osteogenesis imperfecta (OI) to stabilize long bones, often post fracture. We…”
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Targeting adeno-associated viral vectors to fractures and the skeleton by Lee, L, Peacock, L, Lisowski, L, Little, D, Munns, C, Schindeler, A

“…Background & AimGene therapy in the context of the bone remains an underdeveloped field, and most approaches have focused on local delivery of therapeutic…”
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Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib) by El-Hoss, J, Kolind, M, Jackson, M.T, Deo, N, Mikulec, K, McDonald, M.M, Little, C.B, Little, D.G, Schindeler, A

“…Abstract MEK inhibitors (MEKi) PD0325901 and AZD6244 (Selumetinib) are drugs currently under clinical investigation for cancer treatment, however the Ras–MAPK…”
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A Combination of rhBMP-2 (Recombinant Human Bone Morphogenetic Protein-2) and MEK (MAP Kinase/ERK Kinase) Inhibitor PD0325901 Increases Bone Formation in a Murine Model of Neurofibromatosis Type I Pseudarthrosis by El-Hoss, J, Cheng, T, Carpenter, E.C, Sullivan, K, Deo, N, Mikulec, K, Little, D.G, Schindeler, A

“…BACKGROUND:Congenital tibial dysplasia is a severe pediatric condition that classically results in a persistent pseudarthrosis. A majority of these cases are…”
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A sugar-based phase-transitioning delivery system for bone tissue engineering by Cheng, T L, Valtchev, P, Murphy, C M, Cantrill, L C, Dehghani, F, Little, D G, Schindeler, A

“…Bone tissue engineering approaches commonly involve the delivery of recombinant human bone morphogenetic proteins (rhBMPs). However, there are limitations…”
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JNK inhibitor SP600125 promotes osteogenesis in NF1-deficient cells by Sullivan, K, Schindeler, A, Little, D

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Lineage tracking of myogenic progenitors in surgical models of tibial bone repair by Little, D.G, Liu, R, Birke, O, Morse, A, Schindeler, A

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Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation by Yu, Nicole Y C, Schindeler, Aaron, Peacock, Lauren, Mikulec, Kathy, Fitzpatrick, Jane, Ruys, Andrew J, Cooper-White, Justin J, Little, David G

“…We describe two studies encompassing the iterative refinement of a polymer-based rhBMP-2 delivery system for bone tissue engineering. Firstly, we compared the…”
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Modelling bone healing deficiencies in Type 1 neurofibromatosis by Little, D.G, El-Hoss, J, Peacock, L, Mikulec, K, Alexander, I, Schindeler, A

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Rap-011 augments callus formation in closed fractures in rats by Little, D.G, Morse, A, Peacock, L, Mikulec, K, McDonald, M, Schindeler, A

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Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhBMP-2 and anti-resorptive agents by Yu, N Y C, Gdalevitch, M, Murphy, C M, Mikulec, K, Peacock, L, Fitzpatrick, J, Cantrill, L C, Ruys, A J, Cooper-White, J J, Little, D G, Schindeler, A

“…Current clinical delivery of recombinant human bone morphogenetic proteins (rhBMPs) utilises freeze-dried collagen. Despite effective new bone generation,…”
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In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid by Yu, Nicole Y C, Schindeler, Aaron, Peacock, Lauren, Mikulec, Kathy, Baldock, Paul A, Ruys, Andrew J, Little, David G

“…The effects of bone anabolic agents such as bone morphogenetic proteins (BMPs) have the potential to be augmented by co-treatment with an anti-catabolic such…”
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The anabolic and catabolic responses in bone repair by LITTLE, D. G, RAMACHANDRAN, M, SCHINDELER, A

“…The literature on fracture repair has been reviewed. The traditional concepts of delayed and nonunion have been examined in terms of the phased and balanced…”
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The role of MyoD+ muscle progenitor cells in bone formation and repair by Liu, R, Peacock, L, Mikulec, K, Morse, A, Schindeler, A, Little, D.G

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Bmpr1a expression correlates with the osteogenic sensitivity of muscle progenitors by Schindeler, A, Liu, R, Ginn, S.L, Lek, M, North, K.N, Alexander, I.E, Little, D.G

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Selective bone marrow transplantation using low-dose chemotherapy by Morse, A, Schindeler, A, Kramer, B, Alexander, I.E, Gunning, P, Little, D.G

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