Search Results - "Schimmel, Kirsten"

Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces by Haisma, Elisabeth M, Göblyös, Anikó, Ravensbergen, Bep, Adriaans, Alwin E, Cordfunke, Robert A, Schrumpf, Jasmijn, Limpens, Ronald W A L, Schimmel, Kirsten J M, den Hartigh, Jan, Hiemstra, Pieter S, Drijfhout, Jan Wouter, El Ghalbzouri, Abdoelwaheb, Nibbering, Peter H

“…We previously found the LL-37-derived peptide P60.4Ac to be effective against methicillin-resistant Staphylococcus aureus (MRSA) on human epidermal models…”
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3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?-A Scoping Review by Lafeber, Iris, Ruijgrok, Elisabeth J, Guchelaar, Henk-Jan, Schimmel, Kirsten J M

“…3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted…”
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The impact of estimated tumour purity on gene expression-based drug repositioning of Clear Cell Renal Cell Carcinoma samples by Koudijs, Karel K. M., Terwisscha van Scheltinga, Anton G. T., Böhringer, Stefan, Schimmel, Kirsten J. M., Guchelaar, Henk-Jan

“…To find new potentially therapeutic drugs against clear cell Renal Cell Carcinoma (ccRCC), within drugs currently prescribed for other diseases (drug…”
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Development and Bioequivalence of 3D‐Printed Medication at the Point‐of‐Care: Bridging the Gap Toward Personalized Medicine by Lyousoufi, Maryam, Lafeber, Iris, Kweekel, Dinemarie, Winter, Brenda C. M., Swen, Jesse J., Le Brun, Paul P. H., Bijleveld‐Olierook, Erica C. M., Gelder, Teun, Guchelaar, Henk‐Jan, Moes, Dirk Jan A. R., Schimmel, Kirsten J. M.

“…Personalized medicine is currently hampered by the lack of flexible drug formulations. Especially for pediatric patients, manual compounding of personalized…”
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Ephedrine treatment for autoimmune myasthenia gravis by Lipka, Alexander F., MD, Vrinten, Charlotte, MSc, van Zwet, Erik W, PhD, Schimmel, Kirsten JM, PhD, Cornel, Martina C, MD, PhD, Kuijpers, Marja R, Hekster, Yechiel A, PhD, Weinreich, Stephanie S, PhD, Verschuuren, Jan JGM, MD, PhD

“…Highlights • Anecdotal evidence suggests a symptomatic effect of ephedrine in myasthenia gravis. • This series of randomized controlled n-of-1 trials compared…”
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Clinical Pharmacokinetics and Pharmacodynamics of the Epidermal Growth Factor Receptor Inhibitor Panitumumab in the Treatment of Colorectal Cancer by Ketzer, Sander, Schimmel, Kirsten, Koopman, Miriam, Guchelaar, Henk-Jan

“…Despite progress in the treatment of metastatic colorectal cancer (mCRC) in the last 15 years, it is still a condition with a relatively low 5-year survival…”
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Personalised drug repositioning for Clear Cell Renal Cell Carcinoma using gene expression by Koudijs, Karel K. M., Terwisscha van Scheltinga, Anton G. T., Böhringer, Stefan, Schimmel, Kirsten J. M., Guchelaar, Henk-Jan

“…Reversal of cancer gene expression is predictive of therapeutic potential and can be used to find new indications for existing drugs (drug repositioning). Gene…”
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Eradication of meticillin-resistant Staphylococcus aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments by Nibbering, Peter H., Göblyös, Anikó, Adriaans, Alwin E., Cordfunke, Robert A., Ravensbergen, Bep, Rietveld, Marion H., Zwart, Sarah, Commandeur, Suzan, van Leeuwen, Remko, Haisma, Elisabeth M., Schimmel, Kirsten J.M., den Hartigh, Jan, Drijfhout, Jan Wouter, Ghalbzouri, Abdoelwaheb El

“…•P10 is chemically stable and antibacterial in hypromellose gel and Softisan-containing cream, but not in Cetomacrogol.•Reduction in meticillin-resistant…”
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The possibility of obtaining marketing authorization of orphan pharmaceutical compounding preparations: 3,4-DAP for Lambert-Eaton Myasthenic Syndrome by de Wilde, Sofieke, de Jong, Maria G.H., Lipka, Alexander F., Guchelaar, Henk-Jan, Schimmel, Kirsten J.M.

“…Pharmaceutical compounding preparations, produced by (hospital) pharmacies, usually do not have marketing authorization. As a consequence, some of these…”
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Transcriptome Signature Reversion as a Method to Reposition Drugs Against Cancer for Precision Oncology by Koudijs, Karel K M, Terwisscha van Scheltinga, Anton G T, Böhringer, Stefan, Schimmel, Kirsten J M, Guchelaar, Henk-Jan

“…Transcriptome signature reversion (TSR) has been hypothesized as a promising method for discovery and use of existing noncancer drugs as potential drugs in the…”
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Cardiotoxicity of cytotoxic drugs by Schimmel, Kirsten J.M, Richel, Dick J, van den Brink, Renée B.A, Guchelaar, Henk-Jan

“…Cardiotoxicity is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. The mechanism of…”
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Unlicensed pharmaceutical preparations for clinical patient care: Ensuring safety by Wilde, Sofieke, Jong, Maria G.H., Le Brun, Paul P.H., Guchelaar, Henk‐Jan, Schimmel, Kirsten J.M.

“…Most medicinal products dispensed to patients have marketing authorization (MA) to ensure high quality of the product, safety, and efficacy. However, in daily…”
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Aggregated N-of-1 trials for unlicensed medicines for small populations: an assessment of a trial with ephedrine for myasthenia gravis by Weinreich, Stephanie S, Vrinten, Charlotte, Kuijpers, Marja R, Lipka, Alexander F, Schimmel, Kirsten J M, van Zwet, Erik W, Gispen-de Wied, Christine, Hekster, Yechiel A, Verschuuren, Jan J G M, Cornel, Martina C

“…Inexpensive medicines with a long history of use may currently be prescribed off-label for rare indications. Reimbursement is at the discretion of health…”
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Development of a nose cream containing the synthetic antimicrobial peptide P60.4Ac for eradication of methicillin-resistant Staphylococcus aureus carriage by Göblyös, Anikó, Schimmel, Kirsten J M, Valentijn, A Rob P M, Fathers, Lorainne M, Cordfunke, Robert A, Chan, Hee Lam, Oostendorp, Jaap, Nibbering, Peter H, Drijfhout, Jan W, Hiemstra, Pieter S, Hartigh, Jan Den

“…Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing problem, and current treatment options are suboptimal. Nasal carriage of MRSA…”
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A Survey of the Use of Off-Label and Unlicensed Drugs in a Dutch Children's Hospital by t Jong, Geert W, Vulto, Arnold G, de Hoog, Matthijs, Schimmel, Kirsten J. M, Tibboel, Dick, van den Anker, John N

“…The treatment of pediatric patients with drugs in hospitals is being impeded by a shortage in the availability of licensed drugs in an appropriate formulation…”
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Ephedrine as add-on therapy for patients with myasthenia gravis: protocol for a series of randomised, placebo-controlled n-of-1 trials by Vrinten, Charlotte, Lipka, Alexander F, van Zwet, Erik W, Schimmel, Kirsten J M, Cornel, Martina C, Kuijpers, Marja R, Hekster, Yechiel A, Weinreich, Stephanie S, Verschuuren, Jan J G M

“…IntroductionMyasthenia gravis (MG), a rare neuromuscular disease, is often initially treated using acetylcholinesterase inhibitors. Patients who do not respond…”
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Pharmacogenetics of taste: turning bitter pills sweet? by Nagtegaal, Mariëlle J, Swen, Jesse J, Hanff, Lidwien M, Schimmel, Kirsten Jm, Guchelaar, Henk-Jan

“…Poor palatability of oral drug formulations used for young children negatively influences medication intake, resulting in suboptimal treatment. Some children…”
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Limited antitumor-effect associated with toxicity of the experimental cytotoxic drug cyclopentenyl cytosine in NOD/scid mice with acute lymphoblastic leukemia by Schimmel, Kirsten J.M, Nijmeijer, Bart A, van Schie, Marianke L.J, Falkenburg, J.H. Frederik, Guchelaar, Henk-Jan

“…Abstract The experimental cytotoxic drug cyclopentenyl cytosine (CPEC) is a non-competitive inhibitor of the enzyme cytidine triphosphate (CTP) synthethase. We…”
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Unapproved and Off-Label Use of Drugs in a Children's Hospital by `t Jong, Geert W, Vulto, Arnold G, de Hoog, Matthijs, Schimmel, Kirsten J.M, Tibboel, Dick, van den Anker, John N

“…To the Editor: Treatment of children may be difficult because of a shortage of properly formulated or approved drugs. 1 In the Netherlands and elsewhere, many…”
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Quantitative analysis of the experimental cytotoxic drug cyclopentenyl cytosine and its metabolite in plasma with HPLC tandem mass spectrometry by Schimmel, Kirsten, Lenthe, Henk van, Leen, Rene, Kulik, Willem, Verschuur, Arnauld, Guchelaar, Henk-Jan, Kuilenburg, André van

“…The cytotoxic drug cyclopentenyl cytosine (CPEC) is currently being investigated in early clinical trials. Monitoring of plasma levels is required for…”
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