Search Results - "Schimanski, Lisa"

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses by Tan, Tiong Kit, Rijal, Pramila, Rahikainen, Rolle, Keeble, Anthony H., Schimanski, Lisa, Hussain, Saira, Harvey, Ruth, Hayes, Jack W. P., Edwards, Jane C., McLean, Rebecca K., Martini, Veronica, Pedrera, Miriam, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Zagrajek, Adrian K., Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Tully, Matthew, Moffat, Katy, Chiu, Chris, Waters, Ryan, Gray, Ashley, Azhar, Mehreen, Mioulet, Valerie, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Hammond, John A., Tchilian, Elma, Charleston, Bryan, Bailey, Dalan, Tuthill, Tobias J., Graham, Simon P., Duyvesteyn, Helen M. E., Malinauskas, Tomas, Huo, Jiandong, Tree, Julia A., Buttigieg, Karen R., Owens, Raymond J., Carroll, Miles W., Daniels, Rodney S., McCauley, John W., Stuart, David I., Huang, Kuan-Ying A., Howarth, Mark, Townsend, Alain R.

“…There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle…”
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Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern by Skelly, Donal T., Harding, Adam C., Gilbert-Jaramillo, Javier, Knight, Michael L., Longet, Stephanie, Brown, Anthony, Adele, Sandra, Adland, Emily, Brown, Helen, Tipton, Tom, Stafford, Lizzie, Mentzer, Alexander J., Johnson, Síle A., Amini, Ali, Tan, Tiong Kit, Schimanski, Lisa, Huang, Kuan-Ying A., Rijal, Pramila, Frater, John, Goulder, Philip, Conlon, Christopher P., Jeffery, Katie, Dold, Christina, Pollard, Andrew J., Sigal, Alex, de Oliveira, Tulio, Townsend, Alain R., Klenerman, Paul, Dunachie, Susanna J., Barnes, Eleanor, Carroll, Miles W., James, William S.

“…The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines…”
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A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 by Townsend, Alain, Rijal, Pramila, Xiao, Julie, Tan, Tiong Kit, Huang, Kuan-Ying A., Schimanski, Lisa, Huo, Jiandong, Gupta, Nimesh, Rahikainen, Rolle, Matthews, Philippa C., Crook, Derrick, Hoosdally, Sarah, Dunachie, Susanna, Barnes, Eleanor, Street, Teresa, Conlon, Christopher P., Frater, John, Arancibia-Cárcamo, Carolina V., Rudkin, Justine, Stoesser, Nicole, Karpe, Fredrik, Neville, Matthew, Ploeg, Rutger, Oliveira, Marta, Roberts, David J., Lamikanra, Abigail A., Tsang, Hoi Pat, Bown, Abbie, Vipond, Richard, Mentzer, Alexander J., Knight, Julian C., Kwok, Andrew J., Screaton, Gavin R., Mongkolsapaya, Juthathip, Dejnirattisai, Wanwisa, Supasa, Piyada, Klenerman, Paul, Dold, Christina, Baillie, J. Kenneth, Moore, Shona C., Openshaw, Peter J. M., Semple, Malcolm G., Turtle, Lance C. W., Ainsworth, Mark, Allcock, Alice, Beer, Sally, Bibi, Sagida, Skelly, Donal, Stafford, Lizzy, Jeffrey, Katie, O’Donnell, Denise, Clutterbuck, Elizabeth, Espinosa, Alexis, Mendoza, Maria, Georgiou, Dominique, Lockett, Teresa, Martinez, Jose, Perez, Elena, Gallardo Sanchez, Veronica, Scozzafava, Giuseppe, Sobrinodiaz, Alberto, Thraves, Hannah, Joly, Etienne

“…Serological detection of antibodies to SARS-CoV-2 is essential for establishing rates of seroconversion in populations, and for seeking evidence for a level of…”
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Breadth and function of antibody response to acute SARS-CoV-2 infection in humans by Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R

“…Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19 patients with different…”
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Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans by Rijal, Pramila, Elias, Sean C., Machado, Samara Rosendo, Xiao, Julie, Schimanski, Lisa, O’Dowd, Victoria, Baker, Terry, Barry, Emily, Mendelsohn, Simon C., Cherry, Catherine J., Jin, Jing, Labbé, Geneviève M., Donnellan, Francesca R., Rampling, Tommy, Dowall, Stuart, Rayner, Emma, Findlay-Wilson, Stephen, Carroll, Miles, Guo, Jia, Xu, Xiao-Ning, Huang, Kuan-Ying A., Takada, Ayato, Burgess, Gillian, McMillan, David, Popplewell, Andy, Lightwood, Daniel J., Draper, Simon J., Townsend, Alain R.

“…We describe therapeutic monoclonal antibodies isolated from human volunteers vaccinated with recombinant adenovirus expressing Ebola virus glycoprotein (EBOV…”
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Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2 by Huang, Kuan-Ying A., Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Tan, Tiong Kit, Rijal, Pramila, Vester, Susan K., Hills, Rory A., Howarth, Mark, Keeffe, Jennifer R., Cohen, Alexander A., Kakutani, Leesa M., Wu, Yi-Min, Shahed-Al-Mahmud, Md, Chou, Yu-Chi, Bjorkman, Pamela J., Townsend, Alain R., Ma, Che

“…Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection. We isolated a panel of neutralizing anti-receptor-binding domain…”
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The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine by Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Kit Tan, Tiong, Rijal, Pramila, Chen, Cheng-Pin, Cheng, Shu-Hsing, Lee, Wen-Hsin, Chou, Yu-Chi, Townsend, Alain R, Ma, Che, Huang, Kuan-Ying A

“…Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from…”
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Computational mining of B cell receptor repertoires reveals antigen-specific and convergent responses to Ebola vaccination by Richardson, Eve, Bibi, Sagida, McLean, Florence, Schimanski, Lisa, Rijal, Pramila, Ghraichy, Marie, von Niederhäusern, Valentin, Trück, Johannes, Clutterbuck, Elizabeth A, O'Connor, Daniel, Luhn, Kerstin, Townsend, Alain, Peters, Bjoern, Pollard, Andrew J, Deane, Charlotte M, Kelly, Dominic F

“…Outbreaks of Ebolaviruses, such as Sudanvirus (SUDV) in Uganda in 2022, demonstrate that species other than the Zaire ebolavirus (EBOV), which is currently the…”
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A single cycle influenza virus coated in H7 haemagglutinin generates neutralizing antibody responses to haemagglutinin and neuraminidase glycoproteins and protection from heterotypic challenge by Powell, Timothy J, Rijal, Pramila, McEwen-Smith, Rosanna M, Byun, Haewon, Hardwick, Marc, Schimanski, Lisa M, Huang, Kuan-Ying A, Daniels, Rodney S, Townsend, Alain R M

“…A non-replicating form of pseudotyped influenza virus, inactivated by suppression of the haemagglutinin signal sequence (S-FLU), can act as a broadly…”
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Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin by Drakesmith, Hal, Schimanski, Lisa M., Ormerod, Emma, Merryweather-Clarke, Alison T., Viprakasit, Vip, Edwards, Jon P., Sweetland, Emma, Bastin, Judy M., Cowley, Diana, Chinthammitr, Yingyong, Robson, Kathryn J.H., Townsend, Alain R.M.

“…Ferroportin (FP141414148) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we…”
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Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans by Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R

“…[This corrects the article DOI: 10.1371/journal.ppat.1009352.]…”
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The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells by Zhuang, Xiaodong, Tsukuda, Senko, Wrensch, Florian, Wing, Peter A.C., Schilling, Mirjam, Harris, James M., Borrmann, Helene, Morgan, Sophie B., Cane, Jennifer L., Mailly, Laurent, Thakur, Nazia, Conceicao, Carina, Sanghani, Harshmeena, Heydmann, Laura, Bach, Charlotte, Ashton, Anna, Walsh, Steven, Tan, Tiong Kit, Schimanski, Lisa, Huang, Kuan-Ying A., Schuster, Catherine, Watashi, Koichi, Hinks, Timothy S.C., Jagannath, Aarti, Vausdevan, Sridhar R., Bailey, Dalan, Baumert, Thomas F., McKeating, Jane A.

“…The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with…”
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In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations by Schimanski, Lisa M., Drakesmith, Hal, Merryweather-Clarke, Alison T., Viprakasit, Vip, Edwards, Jon P., Sweetland, Emma, Bastin, Judy M., Cowley, Diana, Chinthammitr, Yingyong, Robson, Kathryn J.H., Townsend, Alain R.M.

“…Type IV hemochromatosis is associated with dominant mutations in the SLC40A1 gene encoding ferroportin (FPN). Known as the “ferroportin disease,” this…”
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Persistence of immune responses to the Sinopharm/BBIBP‐CorV vaccine by Jeewandara, Chandima, Aberathna, Inoka Sepali, Pushpakumara, Pradeep Darshana, Kamaladasa, Achala, Guruge, Dinuka, Wijesinghe, Ayesha, Gunasekera, Banuri, Ramu, Shyrar Tanussiya, Kuruppu, Heshan, Ranasinghe, Thushali, Dayarathna, Shashika, Dissanayake, Osanda, Gamalath, Nayanathara, Ekanayake, Dinithi, Jayamali, Jeewantha, Jayathilaka, Deshni, Dissanayake, Madushika, Jayadas, Tibutius Thanesh, Mudunkotuwa, Anushika, Somathilake, Gayasha, Harvie, Michael, Nimasha, Thashmi, Danasekara, Saubhagya, Wijayamuni, Ruwan, Schimanski, Lisa, Rijal, Pramila, Tan, Tiong K., Dong, Tao, Townsend, Alain, Ogg, Graham S., Malavige, Gathsaurie Neelika

“…Background To determine the kinetics and persistence of immune responses following the Sinopharm/BBIBP‐CorV, we investigated immune responses in a cohort of…”
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Structure–function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans by Huang, Kuan-Ying A., Rijal, Pramila, Jiang, Haihai, Wang, Beibei, Schimanski, Lisa, Dong, Tao, Liu, Yo-Min, Chang, Pengxiang, Iqbal, Munir, Wang, Mu-Chun, Chen, Zhihai, Song, Rui, Huang, Chung-Chi, Yang, Jeng-How, Qi, Jianxun, Lin, Tzou-Yien, Li, Ang, Powell, Timothy J., Jan, Jia-Tsrong, Ma, Che, Gao, George F., Shi, Yi, Townsend, Alain R.

“…Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have…”
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Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka by Jeewandara, Chandima, Guruge, Dinuka, Abyrathna, Inoka Sepali, Danasekara, Saubhagya, Gunasekera, Banuri, Pushpakumara, Pradeep Darshana, Madhusanka, Deshan, Jayathilaka, Deshni, Ranasinghe, Thushali, Somathilake, Gayasha, Tanussiya, Shyrar, Jayadas, Tibutius Tanesh, Kuruppu, Heshan, Thashmi, Nimasha, Harvie, Michael, Wijayamuni, Ruwan, Schimanski, Lisa, Tan, T. K., Rijal, Pramila, Xiao, Julie, Ogg, Graham S., Townsend, Alain, Malavige, Gathsaurie Neelika

“…Background: As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried…”
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Kinetics of immune responses to the AZD1222/Covishield vaccine with varying dose intervals in Sri Lankan individuals by Jeewandara, Chandima, Aberathna, Inoka Sepali, Gomes, Laksiri, Pushpakumara, Pradeep Darshana, Danasekara, Saubhagya, Guruge, Dinuka, Ranasinghe, Thushali, Gunasekera, Banuri, Kamaladasa, Achala, Kuruppu, Heshan, Somathilake, Gayasha, Dissanayake, Osanda, Gamalath, Nayanathara, Ekanayake, Dinithi, Jayamali, Jeewantha, Jayathilaka, Deshni, Mudunkotuwa, Anushika, Harvie, Michael, Nimasha, Thashmi, Wijayamuni, Ruwan, Schimanski, Lisa, Rijal, Pramila, Tan, Tiong K., Dong, Tao, Townsend, Alain, Ogg, Graham S., Malavige, Gathsaurie Neelika

“…Background To understand the kinetics of immune responses with different dosing gaps of the AZD1222 vaccine, we compared antibody and T cell responses in two…”
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A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern by Ertesvåg, Nina Urke, Xiao, Julie, Zhou, Fan, Ljostveit, Sonja, Sandnes, Helene, Lartey, Sarah, Sævik, Marianne, Hansen, Lena, Madsen, Anders, Mohn, Kristin G. I., Fjelltveit, Elisabeth, Olofsson, Jan Stefan, Tan, Tiong Kit, Rijal, Pramila, Schimanski, Lisa, Øyen, Siri, Brokstad, Karl Albert, Dunachie, Susanna, Jämsén, Anni, James, William S., Harding, Adam C., Harvala, Heli, Nguyen, Dung, Roberts, David, Zambon, Maria, Townsend, Alain, Langeland, Nina, Cox, Rebecca Jane

“…Background Evaluation of susceptibility to emerging SARS-CoV-2 variants of concern (VOC) requires rapid screening tests for neutralising antibodies which…”
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The Hemochromatosis Protein HFE Inhibits Iron Export from Macrophages by Drakesmith, Hal, Sweetland, Emma, Schimanski, Lisa, Edwards, Jon, Cowley, Diana, Ashraf, Mubeen, Bastin, Judy, Alain R. M. Townsend

“…Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1…”
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Ferroportin: Lack of evidence for multimers by Schimanski, Lisa M., Drakesmith, Hal, Talbott, Charlotte, Horne, Kerry, James, John R., Davis, Simon J., Sweetland, Emma, Bastin, Judy, Cowley, Diana, Townsend, Alain R.M.

“…Ferroportin is a multi-transmembrane glycoprotein that mediates iron export from cells. Mutations in ferroportin are linked to type IV hemochromatosis, a…”
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