Search Results - "Schiller, Peter"

Bi- or multifunctional opioid peptide drugs by Schiller, Peter W.

“…Strategies for the design of bi- or multifunctional drugs are reviewed. A distinction is made between bifunctional drugs interacting in a monovalent fashion…”
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Parallel information processing channels created in the retina by Schiller, Peter H.

“…In the retina, several parallel channels originate that extract different attributes from the visual scene. This review describes how these channels arise and…”
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Memories of Charlie Gross by Schiller, Peter H.

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A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action by Stoeber, Miriam, Jullié, Damien, Lobingier, Braden T., Laeremans, Toon, Steyaert, Jan, Schiller, Peter W., Manglik, Aashish, von Zastrow, Mark

“…Opioid receptors (ORs) precisely modulate behavior when activated by native peptide ligands but distort behaviors to produce pathology when activated by…”
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Molecular Pharmacology of δ-Opioid Receptors by Gendron, Louis, Cahill, Catherine M, von Zastrow, Mark, Schiller, Peter W, Pineyro, Graciela

“…Opioids are among the most effective analgesics available and are the first choice in the treatment of acute severe pain. However, partial efficacy, a tendency…”
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MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1 by Zhu, Huaqing, Yang, Yixin, Wang, Yanpeng, Li, Jianmin, Schiller, Peter W., Peng, Tianqing

“…Aims Free fatty acids induce apoptosis in cardiomyocytes, which is implicated in lipotoxic cardiomyopathy. However, the underlying mechanisms remain not fully…”
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Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development by Szeto, Hazel H., Schiller, Peter W.

“…ABSTRACT Mitochondrial oxidative stress and dysfunction have been implicated in the aging process and in numerous chronic diseases. The need for therapies that…”
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Protective effect of a mitochondria‐targeting peptide against paclitaxel‐induced peripheral neuropathy by Itoh, Kensaku, Shimoyama, Megumi, Schiller, Peter W., Toyama, Satoshi

“…Chemotherapy‐induced peripheral neuropathy (CIPN) is a major side effect of several anticancer agents including paclitaxel, a chemotherapeutic drug widely used…”
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Histone Deacetylase-3 Activation Promotes Tumor Necrosis Factor-α (TNF-α) Expression in Cardiomyocytes during Lipopolysaccharide Stimulation by Zhu, Huaqing, Shan, Limei, Schiller, Peter W., Mai, Antonello, Peng, Tianqing

“…Lipopolysaccharides (LPS) induce tumor necrosis factor-α (TNF-α) production in cardiomyocytes, which contributes to myocardial depression during sepsis…”
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Structural basis for bifunctional peptide recognition at human δ-opioid receptor by Fenalti, Gustavo, Zatsepin, Nadia A, Betti, Cecilia, Giguere, Patrick, Han, Gye Won, Ishchenko, Andrii, Liu, Wei, Guillemyn, Karel, Zhang, Haitao, James, Daniel, Wang, Dingjie, Weierstall, Uwe, Spence, John C H, Boutet, Sébastien, Messerschmidt, Marc, Williams, Garth J, Gati, Cornelius, Yefanov, Oleksandr M, White, Thomas A, Oberthuer, Dominik, Metz, Markus, Yoon, Chun Hong, Barty, Anton, Chapman, Henry N, Basu, Shibom, Coe, Jesse, Conrad, Chelsie E, Fromme, Raimund, Fromme, Petra, Tourwé, Dirk, Schiller, Peter W, Roth, Bryan L, Ballet, Steven, Katritch, Vsevolod, Stevens, Raymond C, Cherezov, Vadim

“…Serial femtosecond crystallography of the human δ-opioid receptor in complex with an endomorphin-derived peptide reveals interactions that are important for…”
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A Cadaveric Study Addressing the Feasibility of Remote Patient Monitoring Prosthesis for Total Knee Arthroplasty by Cushner, Fred D., Schiller, Peter J., Mueller, John Kyle P., Gross, Jeffrey M., Hunter, William L.

“…Since the COVID-19 pandemic of 2020, there has been a marked rise in the use of telemedicine to evaluate patients after total knee arthroplasty (TKA). The…”
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Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury by Zhao, Kesheng, Zhao, Guo-Min, Wu, Dunli, Soong, Yi, Birk, Alex V, Schiller, Peter W, Szeto, Hazel H

“…Reactive oxygen species (ROS) play a key role in promoting mitochondrial cytochrome c release and induction of apoptosis. ROS induce dissociation of cytochrome…”
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Strengthening peptide-based drug activity with novel glyconanoparticle by Lewicky, Jordan D, Martel, Alexandrine L, Fraleigh, Nya L, Boraman, Amanda, Nguyen, Thi M-D, Schiller, Peter W, Shiao, Tze Chieh, Roy, René, Le, Hoang-Thanh

“…The therapeutic application of peptide-based drugs is significantly limited by the rapid proteolytic degradation that occurs when in blood. Encapsulation of…”
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Mannosylated glycoliposomes for the delivery of a peptide kappa opioid receptor antagonist to the brain by Lewicky, Jordan D., Fraleigh, Nya L., Boraman, Amanda, Martel, Alexandrine L., Nguyen, Thi M.-D., Schiller, Peter W., Shiao, Tze Chieh, Roy, René, Montaut, Sabine, Le, Hoang-Thanh

“…[Display omitted] Dynantin is a potent and selective synthetic polypeptide kappa opioid receptor antagonist which has potential antidepressant and…”
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Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes by Lewicky, Jordan D., Fraleigh, Nya L., Martel, Alexandrine L., Nguyen, Thi M.-D., Schiller, Peter W., Mousavifar, Leila, Roy, René, Le, Anh Dzung, Funk, Douglas, Le, Hoang-Thanh

“…Peptide therapeutics offer numerous advantages in the treatment of diseases and disorders of the central nervous system (CNS). However, they are not without…”
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Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists by Charfi, Iness, Nagi, Karim, Mnie-Filali, Ouissame, Thibault, Dominic, Balboni, Gianfranco, Schiller, Peter W, Trudeau, Louis-Eric, Pineyro, Graciela

“…Signaling bias refers to G protein-coupled receptor ligand ability to preferentially activate one type of signal over another. Bias to evoke signaling as…”
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Solid-Phase Azopeptide Diels–Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation by Chingle, Ramesh, Mulumba, Mukandila, Chung, Nga N, Nguyen, Thi M.-D, Ong, Huy, Ballet, Steven, Schiller, Peter W, Lubell, William D

“…Solid-phase chemistry for the synthesis and Diels–Alder reaction of Fmoc-protected azopeptides has been developed and used to construct aza-pipecolyl (azaPip)…”
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Protective Effect of a Mitochondria-Targeted Peptide against the Development of Chemotherapy-Induced Peripheral Neuropathy in Mice by Toyama, Satoshi, Shimoyama, Naohito, Szeto, Hazel H, Schiller, Peter W, Shimoyama, Megumi

“…Several chemotherapeutic agents used for cancer treatment induce dose-limiting peripheral neuropathy that compromises patients’ quality of life and limits…”
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Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling by Yaksh, Tony L, Eddinger, Kelly A, Kokubu, Shinichi, Wang, Zhenping, DiNardo, Anna, Ramachandran, Roshni, Zhu, Yuelian, He, Yajun, Weren, Fieke, Quang, Daphne, Malkmus, Shelle A, Lansu, Katherine, Kroeze, Wesley K, Eliceiri, Brian, Steinauer, Joanne J, Schiller, Peter W, Gmeiner, Peter, Page, Linda M, Hildebrand, Keith R

“…WHAT WE ALREADY KNOW ABOUT THIS TOPICThe formation of intrathecal masses complicates the use of intrathecal opioid therapy for chronic painThe degranulation of…”
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Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins by Audet, Nicolas, Galés, Céline, Archer-Lahlou, Élodie, Vallières, Marc, Schiller, Peter W., Bouvier, Michel, Pineyro, Graciela

“…Heptahelical receptors communicate extracellular information to the cytosolic compartment by binding an extensive variety of ligands. They do so through…”
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