Search Results - "Schiller, Martin R."

The carboxy-terminus, a key regulator of protein function by Sharma, Surbhi, Schiller, Martin R

“…All proteins end with a carboxyl terminus that has unique biophysical properties and is often disordered. Although there are examples of important C-termini…”
Get more information

Severe COVID-19 in Alzheimer's disease: APOE4's fault again? by Xiong, Nian, Schiller, Martin R, Li, Jingwen, Chen, Xiaowu, Lin, Zhicheng

“…Challenges have been recognized in healthcare of patients with Alzheimer's disease (AD) in the COVID-19 pandemic, given a high infection and mortality rate of…”
Get full text

Coupling receptor tyrosine kinases to Rho GTPases—GEFs what's the link by Schiller, Martin R.

“…Rho GTPases are molecular switches involved in the regulation of many cellular processes. This review summarizes work examining how stimulation of receptor…”
Get full text

Synonymous Variants of Uncertain Silence by Giacoletto, Christopher J, Rotter, Jerome I, Grody, Wayne W, Schiller, Martin R

“…Synonymous variants, traditionally regarded as silent mutations due to their lack of impact on protein sequence, structure and function, have been the subject…”
Get full text

Accurate Prediction of Transcriptional Activity of Single Missense Variants in HIV Tat with Deep Learning by Derbel, Houssemeddine, Giacoletto, Christopher J, Benjamin, Ronald, Chen, Gordon, Schiller, Martin R, Liu, Qian

“…Tat is an essential gene for increasing the transcription of all HIV genes, and affects HIV replication, HIV exit from latency, and AIDS progression. The Tat…”
Get full text

Systematic Assessment of Protein C-Termini Mutated in Human Disorders by FitzHugh, Zachary T, Schiller, Martin R

“…All proteins have a carboxyl terminus, and we previously summarized eight mutations in binding and trafficking sequence determinants in the C-terminus that,…”
Get full text

XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks by Benjamin, Ronald, Banerjee, Atoshi, Wu, Xiaogang, Geurink, Corey, Buczek, Lindsay, Eames, Danielle, Trimidal, Sara G, Pluth, Janice M, Schiller, Martin R

“…Double-strand breaks (DSB) are one of the most lethal forms of DNA damage that, if left unrepaired, can lead to genomic instability, cellular transformation,…”
Get full text

Prioritization of Variants for Investigation of Genotype-Directed Nutrition in Human Superpopulations by Nilsson, Pascal D, Newsome, Jacklyn M, Santos, Henry M, Schiller, Martin R

“…Dietary guidelines recommended by key health agencies are generally designed for a global population. However, ethnicity affects human disease and…”
Get full text

The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer by Li, Lei, Tibiche, Chabane, Fu, Cong, Kaneko, Tomonori, Moran, Michael F, Schiller, Martin R, Li, Shawn Shun-Cheng, Wang, Edwin

“…Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment interactions, has been considered to be an evolutionary…”
Get full text

Damaging the Integrated HIV Proviral DNA with TALENs by Strong, Christy L, Guerra, Horacio P, Mathew, Kiran R, Roy, Nervik, Simpson, Lacy R, Schiller, Martin R

“…HIV-1 integrates its proviral DNA genome into the host genome, presenting barriers for virus eradication. Several new gene-editing technologies have emerged…”
Get full text

Single-cell RNA sequencing reveals in vivo osteoimmunology interactions between the immune and skeletal systems by Wang, Shengran, Greenbaum, Jonathan, Qiu, Chuan, Gong, Yun, Wang, Zun, Lin, Xu, Liu, Yong, He, Pei, Meng, Xianghe, Zhang, Qiang, Shen, Hui, Vemulapalli, Krishna Chandra, Sanchez, Fernando L, Schiller, Martin R, Xiao, Hongmei, Deng, Hongwen

“…While osteoimmunology interactions between the immune and skeletal systems are known to play an important role in osteoblast development, differentiation and…”
Get full text

Rapid Induction of Dendritic Spine Morphogenesis by trans-Synaptic EphrinB-EphB Receptor Activation of the Rho-GEF Kalirin by Penzes, Peter, Beeser, Alexander, Chernoff, Jonathan, Schiller, Martin R., Eipper, Betty A., Mains, Richard E., Huganir, Richard L.

“…The morphogenesis of dendritic spines, the major sites of excitatory synaptic transmission in the brain, is important in synaptic development and plasticity…”
Get full text

Loops govern SH2 domain specificity by controlling access to binding pockets by Kaneko, Tomonori, Huang, Haiming, Zhao, Bing, Li, Lei, Liu, Huadong, Voss, Courtney K, Wu, Chenggang, Schiller, Martin R, Li, Shawn Shun-Cheng

“…Cellular functions require specific protein-protein interactions that are often mediated by modular domains that use binding pockets to engage particular…”
Get more information

High-Throughput Phosphotyrosine Profiling Using SH2 Domains by Machida, Kazuya, Thompson, Christopher M., Dierck, Kevin, Jablonowski, Karl, Kärkkäinen, Satu, Liu, Bernard, Zhang, Haimin, Nash, Piers D., Newman, Debra K., Nollau, Peter, Pawson, Tony, Renkema, G. Herma, Saksela, Kalle, Schiller, Martin R., Shin, Dong-Guk, Mayer, Bruce J.

“…Protein tyrosine phosphorylation controls many aspects of signaling in multicellular organisms. One of the major consequences of tyrosine phosphorylation is…”
Get full text

Identifying Pleiotropic SNPs Associated With Femoral Neck and Heel Bone Mineral Density by He, Pei, Meng, Xiang-He, Zhang, Xiao, Lin, Xu, Zhang, Qiang, Jiang, Ri-Li, Schiller, Martin R, Deng, Fei-Yan, Deng, Hong-Wen

“…Genome-wide association studies (GWASs) routinely identify loci associated with risk factors for osteoporosis. However, GWASs with relatively small sample…”
Get full text

The Functional Human C-Terminome by Sharma, Surbhi, Toledo, Oniel, Hedden, Michael, Lyon, Kenneth F, Brooks, Steven B, David, Roxanne P, Limtong, Justin, Newsome, Jacklyn M, Novakovic, Nemanja, Rajasekaran, Sanguthevar, Thapar, Vishal, Williams, Sean R, Schiller, Martin R

“…All translated proteins end with a carboxylic acid commonly called the C-terminus. Many short functional sequences (minimotifs) are located on or immediately…”
Get full text

Data supporting a saturation mutagenesis assay for Tat-driven transcription with the GigaAssay by Benjamin, Ronald, Giacoletto, Christopher J., FitzHugh, Zachary T., Eames, Danielle, Buczek, Lindsay, Wu, Xiaogang, Newsome, Jacklyn, Han, Mira V., Pearson, Tony, Wei, Zhi, Banerjee, Atoshi, Brown, Lancer, Valente, Liz J., Shen, Shirley, Deng, Hong-Wen, Schiller, Martin R.

“…The data in this article are associated with the research paper “GigaAssay – an adaptable high-throughput saturation mutagenesis assay” [1]. The raw data are…”
Get full text

Minimotif Miner: a tool for investigating protein function by Schiller, Martin R, Balla, Sudha, Thapar, Vishal, Verma, Snigdha, Luong, ThaiBinh, Faghri, Tanaz, Huang, Chun-Hsi, Rajasekaran, Sanguthevar, del Campo, Jacob J, Shinn, Jessica H, Mohler, William A, Maciejewski, Mark W, Gryk, Michael R, Piccirillo, Bryan, Schiller, Stanley R

“…In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and…”
Get full text

The history and conceptual framework of assays and screens by Giacoletto, Christopher J., Schiller, Martin R.

“…Since the 16th century, assays and screens have been essential for scientific investigation. However, most methods could be significantly improved, especially…”
Get full text

Achieving high accuracy prediction of minimotifs by Mi, Tian, Rajasekaran, Sanguthevar, Merlin, Jerlin Camilus, Gryk, Michael, Schiller, Martin R

“…The low complexity of minimotif patterns results in a high false-positive prediction rate, hampering protein function prediction. A multi-filter algorithm,…”
Get full text