Search Results - "Schiller, Christian B"

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair by Lammens, Katja, Bemeleit, Derk J., Möckel, Carolin, Clausing, Emanuel, Schele, Alexandra, Hartung, Sophia, Schiller, Christian B., Lucas, Maria, Angermüller, Christof, Söding, Johannes, Sträßer, Katja, Hopfner, Karl-Peter

“…The MR (Mre11 nuclease and Rad50 ABC ATPase) complex is an evolutionarily conserved sensor for DNA double-strand breaks, highly genotoxic lesions linked to…”
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Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells by Braciak, Todd A., Roskopf, Claudia C., Wildenhain, Sarah, Fenn, Nadja C., Schiller, Christian B., Schubert, Ingo A., Jacob, Uwe, Honegger, Annemarie, Krupka, Christina, Subklewe, Marion, Spiekermann, Karsten, Hopfner, Karl-Peter, Fey, Georg H., Aigner, Michael, Krause, Stefan, Mackensen, Andreas, Oduncu, Fuat S.

“…A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single…”
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Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain by Fenn, Sebastian, Schiller, Christian B, Griese, Julia J, Duerr, Harald, Imhof-Jung, Sabine, Gassner, Christian, Moelleken, Joerg, Regula, Joerg Thomas, Schaefer, Wolfgang, Thomas, Markus, Klein, Christian, Hopfner, Karl-Peter, Kettenberger, Hubert

“…Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens,…”
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T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell by Roskopf, Claudia C, Schiller, Christian B, Braciak, Todd A, Kobold, Sebastian, Schubert, Ingo A, Fey, Georg H, Hopfner, Karl-Peter, Oduncu, Fuat S

“…Triplebody 19-3-19, an antibody-derived protein, carries three single chain fragment variable domains in tandem in a single polypeptide chain. 19-3-19 binds…”
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RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation by MIRSCHBERGER, Christian, SCHILLER, Christian B, HOPFNER, Karl-Peter, NIEDERFELLNER, Gerhard, BOSSENMAIER, Birgit, SCHRÄML, Michael, DIMOUDIS, Nikolaos, FRIESS, Thomas, GERDES, Christian A, REIFF, Ulrike, LIFKE, Valeria, HOELZLWIMMER, Gabriele, KOLM, Irene

“…The EGF receptor (EGFR) HER3 is emerging as an attractive cancer therapeutic target due to its central position in the HER receptor signaling network. HER3…”
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Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling by Schiller, Christian B, Lammens, Katja, Guerini, Ilaria, Coordes, Britta, Feldmann, Heidi, Schlauderer, Florian, Möckel, Carolin, Schele, Alexandra, Strässer, Katja, Jackson, Stephen P, Hopfner, Karl-Peter

“…The Mre11–Rad50–Nbs1 (MRN) complex plays a central role in DNA damage signaling. The crystal structures of the Schizosaccharomyces pombe Mre11 catalytic domain…”
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CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells by Schiller, Christian B, Braciak, Todd A, Fenn, Nadja C, Seidel, Ursula J E, Roskopf, Claudia C, Wildenhain, Sarah, Honegger, Annemarie, Schubert, Ingo A, Schele, Alexandra, Lämmermann, Kerstin, Fey, Georg H, Jacob, Uwe, Lang, Peter, Hopfner, Karl-Peter, Oduncu, Fuat S

“…Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for…”
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Structural biology of the Mre11:Nbs1 complex structure yields insights into ataxia–telangiectasia–like disease mutations and DNA damage signaling by Schiller, Christian B., Lammens, Katja, Guerini, Ilaria, Coordes, Britta, Feldmann, Heidi, Schlauderer, Florian, Möckel, Carolin, Schele, Alexandra, Sträβer, Katja, Jackson, Stephen P., Hopfner, Karl–Peter

“…The Mre11–Rad50–Nbs1 (MRN) complex tethers, processes and signals DNA double strand breaks, promoting genomic stability. To understand the functional…”
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