Search Results - "Schilham, M W"

Effect of Ribavirin on the Plasma Viral DNA Load in Patients with Disseminating Adenovirus Infection by Lankester, A. C., Heemskerk, B., Claas, E. C. J., Schilham, M. W., Beersma, M. F. C., Bredius, R. G. M., van Tol, M. J. D., Kroes, A. C. M.

“…Adenovirus (AdV) infections are an increasingly frequent and potentially fatal complication in allogeneic stem cell transplant recipients. To determine the…”
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Preemptive alloimmune intervention in high-risk pediatric acute lymphoblastic leukemia patients guided by minimal residual disease level before stem cell transplantation by Lankester, A C, Bierings, M B, van Wering, E R, Wijkhuijs, A J M, de Weger, R A, Wijnen, J T, Vossen, J M, Versluys, B, Egeler, R M, van Tol, M J D, Putter, H, Révész, T, van Dongen, J J M, van der Velden, V H J, Schilham, M W

“…Relapse of pediatric acute lymphoblastic leukemia (ALL) remains the main cause of treatment failure after allogeneic stem cell transplantation (alloSCT). A…”
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The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis by Albers, H M, Kurreeman, F A S, Houwing-Duistermaat, J J, Brinkman, D M C, Kamphuis, S S M, Girschick, H J, Wouters, C, Van Rossum, M A J, Verduijn, W, Toes, R E M, Huizinga, T W J, Schilham, M W, ten Cate, R

“…Juvenile idiopathic arthritis (JIA) is a chronic disorder in which both genetic and environmental factors are involved. Recently, we identified the TRAF1/C5…”
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Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis by Albers, H. M., Wessels, J. A. M., van der Straaten, R. J. H. M., Brinkman, D. M. C., Suijlekom‐Smit, L. W. A., Kamphuis, S. S. M., Girschick, H. J., Wouters, C., Schilham, M. W., le Cessie, S., Huizinga, T. W. J., ten Cate, R., Guchelaar, H. J.

“…Objective Methotrexate (MTX) is the most commonly used disease‐modifying antirheumatic drug in juvenile idiopathic arthritis (JIA). Currently, individual…”
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Normal development and function of CD8 + cells but markedly decreased helper cell activity in mice lacking CD4 by Rahemtulla, A, Fung-Leung, W. P, Schilham, M. W, Kündig, T. M, Sambhara, S. R, Narendran, A, Arabian, A, Wakeham, A, Paige, C. J, Zinkernagel, R. M, Miller, R. G, Mak, T. W

“…T cells express T-cell antigen receptors (TCR) for the recognition of antigen in conjunction with the products of the major histocompatibility complex. They…”
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Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4 by Schilham, Marco W, Oosterwegel, Mariëtte A, Moerer, Petra, Ya, Jing, de Boer, Piet A. J, van de Wetering, Marc, Verbeek, Sjef, Lamers, Wouter H, Kruisbeek, Ada M, Cumano, Ana, Clevers, Hans

“…A striking example of the relationship between regulation of transcription and phenotype is the central role of the Y-chromosomal gene Sry in mammalian sex…”
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Level of minimal residual disease prior to haematopoietic stem cell transplantation predicts prognosis in paediatric patients with acute lymphoblastic leukaemia: a report of the Pre-BMT MRD Study Group by Krejci, O, van der Velden, V H J, Bader, P, Kreyenberg, H, Goulden, N, Hancock, J, Schilham, M W, Lankester, A, Révész, T, Klingebiel, T, van Dongen, J J M

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Is there a role for minimal residual disease levels in the treatment of ALL patients who receive allogeneic stem cells? by Schilham, M W, Balduzzi, A, Bader, P

“…Relapse is the major complication after allogeneic stem cell transplantation (SCT) for acute lymphoblastic leukemia (ALL) in children. Since it has been…”
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CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis by Reinards, T H C M, Albers, H M, Brinkman, D M C, Kamphuis, S S M, van Rossum, M A J, Girschick, H J, Wouters, C, Hoppenreijs, E P A H, Saurenmann, R K, Hinks, A, Ellis, J A, Bakker, E, Verduijn, W, Slagboom, P, Huizinga, T W J, Toes, R E M, Houwing-Duistermaat, J J, ten Cate, R, Schilham, M W

“…Juvenile idiopathic arthritis (JIA) is considered a complex genetic autoimmune disease. We investigated the association of genetic variants previously…”
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CD8 is needed for development of cytotoxic T cells but not helper T cells by Fung-Leung, W P, Schilham, M W, Rahemtulla, A, Kündig, T M, Vollenweider, M, Potter, J, van Ewijk, W, Mak, T W

“…A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell…”
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Sox4-Deficiency Syndrome in Mice Is an Animal Model for Common Trunk by Ya, Jing, Schilham, Marco W, de Boer, Piet A.J, Moorman, Antoon F.M, Clevers, Hans, Lamers, Wouter H

“…Embryonic mice lacking functional Sox4 transcription factor die from cardiac failure at embryonic day (ED) 14. Heart morphogenesis in these embryos was…”
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Anticarbamylated protein (anti-CarP) antibodies are present in sera of juvenile idiopathic arthritis (JIA) patients by Muller, P C E Hissink, Anink, J, Shi, J, Levarht, E W N, Reinards, T H C M, Otten, M H, van Tol, M J D, Jol-van der Zijde, C M, Brinkman, D M C, Allaart, C F, Hoppenreijs, E P, Koopman-Keemink, Y, Kamphuis, S S M, Dolman, K, van den Berg, J M, van Rossum, M A J, van Suijlekom-Smit, L W A, Schilham, M W, Huizinga, T W J, Toes, R E M, Ten Cate, R, Trouw, L A

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Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis by Albers, H M, Reinards, T H C M, Brinkman, D M C, Kamphuis, S S M, van Rossum, M A J, Hoppenreijs, E P A H, Girschick, H J, Wouters, C, Saurenmann, R K, Bakker, E, Verduijn, W, Slagboom, P, Huizinga, T W J, Toes, R E M, Houwing-Duistermaat, J J, ten Cate, R, Schilham, M W

“…The course of disease in juvenile idiopathic arthritis (JIA) is unpredictable with episodes of activity and remission. In order to identify predictive factors,…”
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Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8 by Schilham, M W, Fung-Leung, W P, Rahemtulla, A, Kuendig, T, Zhang, L, Potter, J, Miller, R G, Hengartner, H, Mak, T W

“…Using the technique of homologous recombination in embryonic stem cells, a mouse strain without functional CD4 and CD8 genes has been generated. Surprisingly,…”
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Clinical course and prognostic value of disease activity in the first two years in different subtypes of juvenile idiopathic arthritis by Albers, H. M., Brinkman, D. M. C., Kamphuis, S. S. M., van Suijlekom‐Smit, L. W. A., van Rossum, M. A. J., Hoppenreijs, E. P. A. H., Girschick, H. J., Wouters, C., Saurenmann, R. K., Houwing‐Duistermaat, J. J., Huizinga, T. W. J., Schilham, M. W., ten Cate, R.

“…Objective Juvenile idiopathic arthritis (JIA) is a heterogeneous disease involving chronic arthritis. The clinical course is characterized by a fluctuating…”
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Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity by van Tol, M J D, Claas, E C J, Heemskerk, B, Veltrop-Duits, L A, de Brouwer, C S, van Vreeswijk, T, Sombroek, C C, Kroes, A C M, Beersma, M F C, de Klerk, E P A, Egeler, R M, Lankester, A C, Schilham, M W

“…Human adenoviruses (HAdV) are a frequent cause of potentially fatal infections in patients after allogeneic stem cell transplantation, especially in children…”
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Animal models of congenital defects in the ventriculoarterial connection of the heart by JING YA, SCHILHAM, M. W, CLEVERS, H, MOORMAN, A. F. M, LAMERS, W. H

“…The embryonic heart functions as a pump without one-way valves. To accomplish this, a long, slowly conducting myocardial structure, the outflow tract,…”
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Immune Reconstitution and Clearance of Human Adenovirus Viremia in Pediatric Stem-Cell Recipients by Heemskerk, Bianca, Lankester, Arjan C., Vreeswijk, Tamara van, Beersma, Matthias F. C., Claas, Eric C. J., Veltrop-Duits, Louise A., Kroes, Aloys C. M., Vossen, Jaak M. J. J., Schilham, Marco W., van Tol, Maarten J. D.

“…Background. Human adenovirus (HAdV) infections are increasingly frequent complications of allogeneic stem-cell transplantation (SCT), especially in children…”
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High Levels of Adenovirus DNA in Serum Correlate with Fatal Outcome of Adenovirus Infection in Children after Allogeneic Stem-Cell Transplantation by Schilham, Marco W., Claas, Eric C., van Zaane, Wouter, Heemskerk, Bianca, Vossen, Jaak M., Lankester, Arjan C., Toes, Rene E., Echavarria, Marcela, Kroes, Aloys C., van Tol, Maarten J.

“…An increase in the incidence of adenovirus (AdV) infection leading to death among children who have undergone allogeneic stem-cell transplantation has made it…”
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Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man by Santos, M, Schilham, M W, Rademakers, L H, Marx, J J, de Sousa, M, Clevers, H

“…Previously, hepatic iron overload resembling that in hereditary hemachromatosis (HH) has been found in beta 2-microglobulin knockout (beta 2m-/-) mice. We have…”
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