Gastrointestinal autonomic nerve tumor (GANT) associated with Von Recklinghausen's disease

Here we describe a case of gastrointestinal autonomic nerve tumor (GANT) arosen in a patient with von Recklinghausen's disease. To the best of our knowledge, only four other similar cases have been previously reported in the literature. Histologically, the tumour was composed of spindle shaped...

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Bibliographic Details
Published in:	Pathologica Vol. 90; no. 6; p. 792
Main Authors:	Damiani, S, Schildkraut, P, Riguzzi, P, Biasiucci, A, Tardio, M L, Eusebi, V
Format:	Journal Article
Language:	Italian
Published:	Italy 01-12-1998
Subjects:	Autonomic Nervous System Diseases - complications Autonomic Nervous System Diseases - pathology Biomarkers, Tumor - analysis Gastrointestinal Neoplasms - chemistry Gastrointestinal Neoplasms - complications Gastrointestinal Neoplasms - pathology Humans Immunohistochemistry Male Middle Aged Neurofibromatosis 1 - complications Neurofibromatosis 1 - pathology Phosphopyruvate Hydratase - analysis Synaptophysin - analysis Vimentin - analysis
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Summary:	Here we describe a case of gastrointestinal autonomic nerve tumor (GANT) arosen in a patient with von Recklinghausen's disease. To the best of our knowledge, only four other similar cases have been previously reported in the literature. Histologically, the tumour was composed of spindle shaped cells arranged in short bundles. The neoplastic cells had pleomorphic nuclei and numerous mitoses. Immunohistochemical investigation displayed evidence of neural differentiation. Neoplastic cells were diffusely anti-synaptophysin, anti-neuron specific enolase and anti-vimentin positive. The clinicopathological features of the present case are described and discussed together with those of the other previously reported cases.
ISSN:	0031-2983