Search Results - "Schiffers, Paul M. H."

Hypoxia-induced mitochondrial abnormalities in cells of the placenta by Vangrieken, Philippe, Al-Nasiry, Salwan, Bast, Aalt, Leermakers, Pieter A, Tulen, Christy B M, Janssen, Ger M J, Kaminski, Iris, Geomini, Iris, Lemmens, Titus, Schiffers, Paul M H, van Schooten, Frederik J, Remels, Alex H V

“…Impaired utero-placental perfusion is a well-known feature of early preeclampsia and is associated with placental hypoxia and oxidative stress. Although…”
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The direct and sustained consequences of severe placental hypoxia on vascular contractility by Vangrieken, Philippe, Al-Nasiry, Salwan, Janssen, Ger M J, Weseler, Antje R, Spaanderman, Marc E, Bast, Aalt, Schiffers, Paul M H

“…Preeclampsia is a major health problem in human pregnancy, severely complicating 5-8% of all pregnancies. The emerging molecular mechanism is that conditions…”
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Placental hypoxia-induced alterations in vascular function, morphology, and endothelial barrier integrity by Vangrieken, Philippe, Remels, Alex H. V., Al-Nasiry, Salwan, Bast, Aalt, Janssen, Ger. M. J., von Rango, Ulrike, Vroomans, Daan, Pinckers, Yannick C. W., van Schooten, Frederik J., Schiffers, Paul M. H.

“…Preeclampsia (PE) is a pregnancy-related disorder characterized by hypertension and proteinuria that affects 3–10% of all pregnancies. Although its…”
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NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype by Elbatreek, Mahmoud H, Sadegh, Sepideh, Anastasi, Elisa, Guney, Emre, Nogales, Cristian, Kacprowski, Tim, Hassan, Ahmed A, Teubner, Andreas, Huang, Po-Hsun, Hsu, Chien-Yi, Schiffers, Paul M H, Janssen, Ger M, Kleikers, Pamela W M, Wipat, Anil, Baumbach, Jan, De Mey, Jo G R, Schmidt, Harald H H W

“…Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10 cases, the molecular cause, however, is unknown. One…”
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Placental Mitochondrial Abnormalities in Preeclampsia by Vangrieken, Philippe, Al-Nasiry, Salwan, Bast, Aalt, Leermakers, Pieter A, Tulen, Christy B M, Schiffers, Paul M H, van Schooten, Frederik J, Remels, Alex H V

“…Preeclampsia complicates 5-8% of all pregnancies worldwide, and although its pathophysiology remains obscure, placental oxidative stress and mitochondrial…”
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Placental Methylglyoxal in Preeclampsia: Vascular and Biomarker Implications by Vangrieken, Philippe, Al-Nasiry, Salwan, Remels, Alex H V, Schiffers, Paul M H, Janssen, Emma, Nass, Stefanie, Scheijen, Jean L J M, Spaanderman, Marc E A, Schalkwijk, Casper G

“…Preeclampsia is a multifaceted syndrome that includes maternal vascular dysfunction. We hypothesize that increased placental glycolysis and hypoxia in…”
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Effects of interacting networks of cardiovascular risk genes on the risk of type 2 diabetes mellitus (the CODAM study) by Greevenboek, M.M. van, Zhang, J, Kallen, C.J, Schiffers, P.M, Feskens, E.J.M, Bruin, T.W

“…Genetic dissection of complex diseases requires innovative approaches for identification of disease-predisposing genes. A well-known example of a human complex…”
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Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium by Donker, Dirk W, Maessen, Jos G, Verheyen, Fons, Ramaekers, Frans C, Spätjens, Roel L H M G, Kuijpers, Helma, Ramakers, Christian, Schiffers, Paul M H, Vos, Marc A, Crijns, Harry J G M, Volders, Paul G A

“…It is poorly understood how mechanical stimuli influence in vivo myocardial remodeling during chronic hemodynamic overload. Combined quantitation of…”
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Imaging evidence for endothelin ETA/ETB receptor heterodimers in isolated rat mesenteric resistance arteries by Kapsokalyvas, Dimitrios, Schiffers, Paul M.H., Maij, Nathan, Suylen, Dennis P., Hackeng, Tilman M., van Zandvoort, Marc A.M.J., De Mey, Jo G.R.

“…In engineered cells, endothelin ETA and ETB receptors can heterodimerize. We tested whether this can also be observed in native tissue. Rat mesenteric…”
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Imaging Collagen in Intact Viable Healthy and Atherosclerotic Arteries Using Fluorescently Labeled CNA35 and Two-Photon Laser Scanning Microscopy by Megens, Remco T.A., Egbrink, Mirjam G.A. oude, Cleutjens, Jack P.M., Kuijpers, Marijke J.E., Schiffers, Paul H.M., Merkx, Maarten, Slaaf, Dick W., van Zandvoort, Marc A.M.J.

“…We evaluated CNA35 as a collagen marker in healthy and atherosclerotic arteries of mice after both ex vivo and in vivo administration and as a molecular…”
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Reduced responsiveness of rat mesenteric resistance artery smooth muscle to phenylephrine and calcium following myocardial infarction by Stassen, Frank R. M., Willemsen, Maurice J. J. M. F., Janssen, Ger M. J., Fazzi, Gregorio E., Schiffers, Paul M. H., Smits, Jos F. M., De Mey, Jo G. R.

“…We evaluated responses of peripheral resistance arterial smooth muscle to α1‐adrenoceptor stimulation in a rat model of heart failure in relation to…”
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Uterine Artery Structural and Functional Changes During Pregnancy in Tissue Kallikrein–Deficient Mice by Hilgers, Rob H.P, Bergaya, Sonia, Schiffers, Paul M.H, Meneton, Pierre, Boulanger, Chantal M, Henrion, Daniel, Lévy, Bernard I, De Mey, Jo G.R

“…OBJECTIVE—Tissue kallikrein (TK) participates in acute flow-induced dilatation (FID) of large arteries. We investigated whether TK deficiency blunts FID and…”
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Tissue Angiotensin-Converting Enzyme in Imposed and Physiological Flow-Related Arterial Remodeling in Mice by Hilgers, Rob H.P, Schiffers, Paul M.H, Aartsen, Wendy M, Fazzi, Gregorio E, Smits, Jos F.M, De Mey, Jo G.R

“…OBJECTIVE—To test whether membrane-bound angiotensin I-converting enzyme (t-ACE) is involved in arterial remodeling, we applied unilateral carotid artery (CA)…”
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Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR by Lemkens, Pieter, Spijkers, Leon Ja, Meens, Merlijn J, Nelissen, Jelly, Janssen, Ben, Peters, Stephan Lm, Schiffers, Paul Mh, De Mey, Jo Gr

“…Endothelin 1 (ET-1), a potent vasoconstrictor, pro-mitogenic and pro-inflammatory peptide, may promote development of endothelial dysfunction and arterial…”
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Mesenteric small artery changes after vasoconstrictor infusion in young rats by Boonen, H C, Daemen, M J, Eerdmans, P H, Fazzi, G E, van Kleef, E M, Schiffers, P M, De Mey, J G

“…We evaluated whether chronic alpha 1-adrenergic stimulation, angiotensin II (AII), or increased blood pressure (BP) alters resistance arterial structure and…”
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Dual neural peptidase/endothelin-converting enzyme inhibition improves endothelial function in mesenteric resistance arteries of young spontaneously hypertensive rats by Lemkens, Pieter, Nelissen, Jelly, Meens, Merlijn J.P.M.T, Janssen, Ben J.A, Schiffers, Paul M.H, De Mey, Jo G.R

“…BACKGROUND:Endothelin-1 (ET1) is a potent vasoconstrictor peptide with pro-mitogenic and pro-inflammatory properties and is therefore of interest in the…”
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Impaired flow-induced arterial remodeling in DOCA-salt hypertensive rats by Lemkens, Pieter, Nelissen, Jelly, Meens, Merlijn J P M T, Fazzi, Gregorio E, Janssen, Ger J M, Debets, Jacques J M, Janssen, Ben J A, Schiffers, Paul M H, De Mey, Jo G R

“…Arteries from young healthy animals respond to chronic changes in blood flow and blood pressure by structural remodeling. We tested whether the ability to…”
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Dual neural endopeptidase/endothelin-converting [corrected] enzyme inhibition improves endothelial function in mesenteric resistance arteries of young spontaneously hypertensive rats by Lemkens, Pieter, Nelissen, Jelly, Meens, Merlijn J P M T, Janssen, Ben J A, Schiffers, Paul M H, De Mey, Jo G R

“…Endothelin-1 (ET1) is a potent vasoconstrictor peptide with pro-mitogenic and pro-inflammatory properties and is therefore of interest in the development of…”
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Dual ECE/NEP inhibition and ETA/B receptor antagonists: Two ways of inhibiting endogenous ET‐1 effects in resistance arteries by Lemkens, Pieter, Nelissen, Jelly, Meens, Merlijn JPMT, Bost, Jet GP, Janssen, Ben JA, Schiffers, Paul MH, De Mey, Jo GR

“…Endothelin‐1 (ET‐1), a 21 amino acid peptide, can be formed by endothelin converting enzyme (ECE) and neutral endopeptidases (NEP). The DOCA‐salt hypertension…”
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A positive and reversible relationship between adrenergic nerves and alpha-1A adrenoceptors in rat arteries by Stassen, F R, Maas, R G, Schiffers, P M, Janssen, G M, De Mey, J G

“…We evaluated the relationship between the presence of adrenergic nerves and the presence of alpha-1 adrenoceptors (alpha-1 AR) in the arterial tree of the rat…”
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