Search Results - "Schifferli, Jurg A"

Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome by Cumpelik, Arun, Ankli, Barbara, Zecher, Daniel, Schifferli, Jürg A

“…Gout is a highly inflammatory but self-limiting joint disease induced by the precipitation of monosodium urate (MSU) crystals. While it is well established…”
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Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells by Eken, Ceylan, Gasser, Olivier, Zenhaeusern, Gabriela, Oehri, Ineke, Hess, Christoph, Schifferli, Jurg A

“…Polymorphonuclear neutrophils (PMNs) are a key component of the innate immune system. Their activation leads to the release of potent antimicrobial agents…”
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Emission of membrane vesicles: roles in complement resistance, immunity and cancer by Pilzer, David, Gasser, Olivier, Moskovich, Oren, Schifferli, Jurg A, Fishelson, Zvi

“…Complement-mediated cell death is caused by C5b-9, the membrane attack complex (MAC) composed of the five complement proteins C5b, C6, C7, C8, and C9. Assembly…”
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Platelet-Derived Ectosomes Reduce NK Cell Function by Sadallah, Salima, Schmied, Laurent, Eken, Ceylan, Charoudeh, Hojjatollah Nozad, Amicarella, Francesca, Schifferli, Jürg A

“…Platelet (PLT) transfusions are potentially life saving for individuals with low PLT numbers; however, previous work revealed that PLT transfusions are…”
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Immune Adherence Revisited: Novel Players in an Old Game by Hess, Christoph, Schifferli, Jurg A

“…Christoph Hess 1 and Jürg A. Schifferli 2 1 Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital/Harvard…”
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Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis by Gasser, Olivier, Schifferli, Jürg A.

“…On activation, human neutrophils release microparticles, called ectosomes, directly from the cell surface membrane. Microparticles from platelets, endothelial…”
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Microparticles (ectosomes) shed by stored human platelets downregulate macrophages and modify the development of dendritic cells by Sadallah, Salima, Eken, Ceylan, Martin, Perrine J, Schifferli, Jürg A

“…Microparticles (MP) shed by platelets (PLT) during storage have procoagulant activities, but little is known about their properties to modify inflammation or…”
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Case 40-2006: Anemia and Low HDL Cholesterol by Schifferli, Jürg A

“…To the Editor: In the Case Record of a patient with anemia and a low level of high-density lipoprotein (HDL) cholesterol, presented by Murali and colleagues…”
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A Peptide Derived from the Parasite Receptor, Complement C2 Receptor Inhibitor Trispanning, Suppresses Immune Complex-Mediated Inflammation in Mice by Inal, Jameel M, Schneider, Brigitte, Armanini, Marta, Schifferli, Jurg A

“…Complement C2 receptor inhibitor trispanning (CRIT) is a Schistosoma protein that binds the human complement protein, C2. We recently showed that peptides…”
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Erythrocyte-derived ectosomes have immunosuppressive properties by Sadallah, Salima, Eken, Ceylan, Schifferli, Jürg A.

“…Several clinical studies have suggested that blood transfusions are immunosuppressive. Whereas there have been reports describing immunosuppression induced by…”
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Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages by Eken, Ceylan, Sadallah, Salima, Martin, Perrine J, Treves, Susan, Schifferli, Jürg A

“…Abstract Ectosomes are vesicles shed directly from the cell surface. Human polymorphonuclear neutrophils release ectosomes (PMN-Ect) upon their activation…”
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Complement Receptor 1 (CD35) on Human Reticulocytes: Normal Expression in Systemic Lupus Erythematosus and HIV-Infected Patients by Lach-Trifilieff, Estelle, Marfurt, Jutta, Schwarz, Sybille, Sadallah, Salima, Schifferli, Jurg A

“…The low levels of complement receptor 1 (CR1) on erythrocytes in autoimmune diseases and AIDS may be due to accelerated loss in the circulation, or to a…”
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Microparticles released by human neutrophils adhere to erythrocytes in the presence of complement by Gasser, Olivier, Schifferli, Jürg A.

“…The release of cell surface-derived microparticles, or ectosomes, has now been described for many different cell types. In various diseases characterized by…”
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Erythrocyte-Derived Microvesicles Amplify Systemic Inflammation by Thrombin-Dependent Activation of Complement by Zecher, Daniel, Cumpelik, Arun, Schifferli, Jürg A

“…OBJECTIVE—Transfusion of aged blood has been associated with increased morbidity and mortality in critically ill patients. During storage, erythrocytes release…”
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The role of complement and its receptor in the elimination of immune complexes by Schifferli, J A, Ng, Y C, Peters, D K

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Atypical hemolytic uremic syndrome: update on the complement system and what is new by Hirt-Minkowski, Patricia, Dickenmann, Michael, Schifferli, Jürg A

“…Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is…”
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Complement C2 Receptor Inhibitor Trispanning: A Novel Human Complement Inhibitory Receptor by Inal, Jameel M, Hui, Kwok-Min, Miot, Sylvie, Lange, Sigrun, Ramirez, Marcel Ivan, Schneider, Brigitte, Krueger, Gerhard, Schifferli, Jurg-A

“…The complement system presents a powerful defense against infection and is tightly regulated to prevent damage to self by functionally equivalent soluble and…”
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Complement Mediates the Binding of HIV to Erythrocytes by Horakova, Eliska, Gasser, Olivier, Sadallah, Salima, Inal, Jameel M, Bourgeois, Guillaume, Ziekau, Ingrid, Klimkait, Thomas, Schifferli, Jurg A

“…A fraction of HIV is associated with erythrocytes even when the virus becomes undetectable in plasma under antiretroviral therapy. The aim of the present work…”
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Monomeric Complement-Activating IgG Paraproteins by Trendelenburg, Marten, Hess, Christoph, Kondo-Oestreicher, Mitsuko, Tissot, Jean D, Spath, Peter, Schifferli, Jurg A

“…Three patients presented a unique syndrome of recurrent panniculitis with an IgGkappa paraprotein and depletion of the early components of the classical…”
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Ectosomes Released by Polymorphonuclear Neutrophils Induce a MerTK-dependent Anti-inflammatory Pathway in Macrophages by Eken, Ceylan, Martin, Perrine J., Sadallah, Salima, Treves, Susan, Schaller, Monica, Schifferli, Jürg A.

“…At the earliest stage of activation, human polymorphonuclear neutrophils release vesicles derived directly from the cell surface. These vesicles, called…”
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