Search Results - "Schifferli, Jürg"

Platelet-Derived Ectosomes Reduce NK Cell Function by Sadallah, Salima, Schmied, Laurent, Eken, Ceylan, Charoudeh, Hojjatollah Nozad, Amicarella, Francesca, Schifferli, Jürg A

“…Platelet (PLT) transfusions are potentially life saving for individuals with low PLT numbers; however, previous work revealed that PLT transfusions are…”
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Erythrocyte-Derived Microvesicles Amplify Systemic Inflammation by Thrombin-Dependent Activation of Complement by Zecher, Daniel, Cumpelik, Arun, Schifferli, Jürg A

“…OBJECTIVE—Transfusion of aged blood has been associated with increased morbidity and mortality in critically ill patients. During storage, erythrocytes release…”
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Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis by Gasser, Olivier, Schifferli, Jürg A.

“…On activation, human neutrophils release microparticles, called ectosomes, directly from the cell surface membrane. Microparticles from platelets, endothelial…”
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Microparticles (ectosomes) shed by stored human platelets downregulate macrophages and modify the development of dendritic cells by Sadallah, Salima, Eken, Ceylan, Martin, Perrine J, Schifferli, Jürg A

“…Microparticles (MP) shed by platelets (PLT) during storage have procoagulant activities, but little is known about their properties to modify inflammation or…”
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Ectosomes released by platelets induce differentiation of CD4+T cells into T regulatory cells by Sadallah, S, Amicarella, F, Eken, C, Iezzi, G, Schifferli, J A

“…Accumulating evidence suggests an immune-modulatory role for platelets (PLT) and PLT-derived microvesicles. In particular, ectosomes, i.e. vesicles budding…”
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Ectosomes Released by Polymorphonuclear Neutrophils Induce a MerTK-dependent Anti-inflammatory Pathway in Macrophages by Eken, Ceylan, Martin, Perrine J., Sadallah, Salima, Treves, Susan, Schaller, Monica, Schifferli, Jürg A.

“…At the earliest stage of activation, human polymorphonuclear neutrophils release vesicles derived directly from the cell surface. These vesicles, called…”
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Proteomic analysis of podocyte exosome-enriched fraction from normal human urine by Prunotto, Marco, Farina, Annarita, Lane, Lydie, Pernin, Agnès, Schifferli, Jürg, Hochstrasser, Denis F., Lescuyer, Pierre, Moll, Solange

“…Urine results from a coordinated activity of glomerular and tubular compartments of the kidney. As a footprint of these cellular functional processes, urinary…”
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Erythrocyte-derived ectosomes have immunosuppressive properties by Sadallah, Salima, Eken, Ceylan, Schifferli, Jürg A.

“…Several clinical studies have suggested that blood transfusions are immunosuppressive. Whereas there have been reports describing immunosuppression induced by…”
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Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages by Eken, Ceylan, Sadallah, Salima, Martin, Perrine J, Treves, Susan, Schifferli, Jürg A

“…Abstract Ectosomes are vesicles shed directly from the cell surface. Human polymorphonuclear neutrophils release ectosomes (PMN-Ect) upon their activation…”
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Ectosomes as immunomodulators by Sadallah, Salima, Eken, Ceylan, Schifferli, Jürg A.

“…Considerable progress has been made in recognizing microvesicles as important mediators of intercellular communication rather than irrelevant cell debris…”
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Microvesicles are messengers by Schifferli, Jürg A.

“…Issue Title: Small Vesicle as Immune Modulators…”
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Pathophysiology of Lower Extremity Edema in Acute Heart Failure Revisited by Breidthardt, Tobias, MD, Irfan, Affan, MD, Klima, Theresia, MD, Drexler, Beatrice, MD, Balmelli, Cathrin, MD, Arenja, Nisha, MD, Socrates, Thenral, MD, Ringger, Rebekka, MD, Heinisch, Corinna, MD, Ziller, Ronny, MD, Schifferli, Jürg, MD, Meune, Christophe, MD, PhD, Mueller, Christian, MD

“…Abstract Background The pathophysiology and key determinants of lower extremity edema in patients with acute heart failure are poorly investigated. Methods We…”
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Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome by Cumpelik, Arun, Ankli, Barbara, Zecher, Daniel, Schifferli, Jürg A

“…Gout is a highly inflammatory but self-limiting joint disease induced by the precipitation of monosodium urate (MSU) crystals. While it is well established…”
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Microparticles released by human neutrophils adhere to erythrocytes in the presence of complement by Gasser, Olivier, Schifferli, Jürg A.

“…The release of cell surface-derived microparticles, or ectosomes, has now been described for many different cell types. In various diseases characterized by…”
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Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils by Gasser, Olivier, Hess, Christoph, Miot, Sylvie, Deon, Catherine, Sanchez, Jean-Charles, Schifferli, J.ürg A

“…Human neutrophils release vesicles when activated in vitro and in vivo, in local and systemic inflammation. We have suggested that the presence of these…”
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Atypical hemolytic uremic syndrome: update on the complement system and what is new by Hirt-Minkowski, Patricia, Dickenmann, Michael, Schifferli, Jürg A

“…Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is…”
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Complement C2 Receptor Inhibitor Trispanning: A Novel Human Complement Inhibitory Receptor by Inal, Jameel M, Hui, Kwok-Min, Miot, Sylvie, Lange, Sigrun, Ramirez, Marcel Ivan, Schneider, Brigitte, Krueger, Gerhard, Schifferli, Jurg-A

“…The complement system presents a powerful defense against infection and is tightly regulated to prevent damage to self by functionally equivalent soluble and…”
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Complement Mediates the Binding of HIV to Erythrocytes by Horakova, Eliska, Gasser, Olivier, Sadallah, Salima, Inal, Jameel M, Bourgeois, Guillaume, Ziekau, Ingrid, Klimkait, Thomas, Schifferli, Jurg A

“…A fraction of HIV is associated with erythrocytes even when the virus becomes undetectable in plasma under antiretroviral therapy. The aim of the present work…”
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Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells by Eken, Ceylan, Gasser, Olivier, Zenhaeusern, Gabriela, Oehri, Ineke, Hess, Christoph, Schifferli, Jurg A

“…Polymorphonuclear neutrophils (PMNs) are a key component of the innate immune system. Their activation leads to the release of potent antimicrobial agents…”
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Haemolytic uraemic syndrome caused by factor H mutation: is single kidney transplantation under intensive plasmatherapy an option? by Hirt-Minkowski, Patricia, Schaub, Stefan, Mayr, Michael, Schifferli, Jürg A., Dickenmann, Michael, Frémeaux-Bacchi, Véronique, Steiger, Jürg

“…Complement factor H (CFH) mutation is one of the causes of atypical haemolytic uraemic syndrome (aHUS). Patients with CFH mutation-associated aHUS progress…”
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