Search Results - "Schiff, Devora"

Ionizing Radiation Sensitizes Breast Cancer Cells to Bcl-2 Inhibitor, ABT-737, through Regulating Mcl-1 by Wu, Hao, Schiff, Devora S., Lin, Yong, Neboori, Hanmanth J. R., Goyal, Sharad, Feng, Zhaohui, Haffty, Bruce G.

“…Breast-conserving surgery followed by radiation therapy has become the standard of care for early stage breast cancer. However, there are some patients that…”
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Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation by Schonewolf, Caitlin A, Mehta, Monal, Schiff, Devora, Wu, Hao, Haffty, Bruce G, Karantza, Vassiliki, Jabbour, Salma K

“…AIM:To investigate whether the inhibition of autophagy by chloroquine(CQ)sensitizes rectal tumors to radiation therapy(RT)or concurrent…”
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Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancer by Jhawar, Sachin R, Wang, Shang-Jui, Thandoni, Aditya, Bommareddy, Praveen K, Newman, Jenna H, Giurini, Eileena F, Marzo, Amanda L, Kuzel, Timothy M, Gupta, Vineet, Reiser, Jochen, Daniels, Preston, Schiff, Devora, Mitchell, Darrion, LeBoeuf, Nicole R, Simmons, Christopher, Goyal, Sharad, Lasfar, Ahmed, Guevara-Patino, Jose A, Haffty, Bruce G, Kaufman, Howard L, Silk, Ann W, Zloza, Andrew

“…BackgroundImmunotherapies are becoming front-line treatments for many advanced cancers, and combinations of two or more therapies are beginning to be…”
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Is Ki-67 Expression Prognostic for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast Conservation Therapy (BCT)? by Hafeez, Farhaan, MS, Neboori, Hanmanth J., MD, Harigopal, Malini, MD, Wu, Hao, PhD, Haffty, Bruce G., MD, Yang, Qifeng, MD, Schiff, Devora, PhD, Moran, Meena S., MD

“…Purpose Ki-67 is a human nuclear protein whose expression is strongly up-regulated in proliferating cells and can be used to determine the growth fraction in…”
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Clinicopathologic Significance of Excision Repair Cross-Complementation 1 Expression in Patients Treated With Breast-Conserving Surgery and Radiation Therapy by Goyal, Sharad, M.D, Parikh, Rahul R., M.D, Green, Camille, M.D, Schiff, Devora, B.S, Moran, Meena S., M.D, Yang, Qifeng, M.D., Ph.D, Haffty, Bruce G., M.D

“…Purpose The excision repair cross-complementation 1 (ERCC1) enzyme plays a rate-limiting role in the nucleotide excision repair pathway and is associated with…”
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Evaluation of Single Nucleotide Polymorphisms (SNPs) in the p53 Binding Protein 1 ( TP53BP1 ) Gene in Breast Cancer Patients Treated With Breast-Conserving Surgery and Whole-Breast Irradiation (BCS + RT) by Haffty, Bruce G., M.D, Goyal, Sharad, M.D, Kulkarni, Diptee, Ph.D, Green, Camille, M.D, Vazquez, Alexi, Ph.D, Schiff, Devora, B.S, Moran, Meena S., M.D, Yang, Qifeng, M.D., Ph.D, Ganesan, Shridar, M.D, Hirsfield, Kim M., M.D., Ph.D

“…Purpose TP53BP1 is a key component of radiation-induced deoxyribonucleic acid damage repair. The purpose of this study was to evaluate the significance of a…”
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Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy by Ferro, Adam, Goyal, Sharad, Kim, Sinae, Wu, Hao, Taunk, Neil K., Schiff, Devora, Pirlamarla, Aneesh, Haffty, Bruce G.

“…Purpose. The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation…”
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Abstract P5-05-07: Foxo3a activation contributes to the synergy of imipridone and radiation in triple-negative breast cancer by Wang, Shang-Jui, Schiff, Devora, Wu, Hao, Jhawar, Sachin, Haffty, Bruce G

“…Abstract Purpose/Objective: Imipridone (IMIP) is a small molecule DRD2 antagonist that has shown efficacy in preclinical and early phase clinical studies in…”
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The glutamate release inhibitor riluzole increases DNA damage and enhances cytotoxicity in human glioma cells, in vitro and in vivo by Khan, Atif J, LaCava, Stephanie, Mehta, Monal, Schiff, Devora, Thandoni, Aditya, Jhawar, Sachin, Danish, Shabbar, Haffty, Bruce G, Chen, Suzie

“…High-grade gliomas are lethal malignancies that cause morbidity and mortality due to local progression rather than metastatic spread. Our group has previously…”
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VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells by Khan, Atif J, Misenko, Sarah M, Thandoni, Aditya, Schiff, Devora, Jhawar, Sachin R, Bunting, Samuel F, Haffty, Bruce G

“…DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We demonstrate the selectivity of…”
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Radiation Therapy and Talimogene Laherparepvec (TVEC) Synergize in the Treatment of Melanoma by Jhawar, Sachin R, Goyal, Sharad, Thandoni, Aditya, Bommareddy, Praveen, Hassan, Suemair, Schiff, Devora, Haffty, Bruce G, Kaufman, Howard, Zloza, Andrew

“…Abstract Talimogene laherparepvec (TVEC), an oncolytic virus, is an FDA-approved therapy that increases the overall survival of locally advanced and metastatic…”
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Abstract 2765: Combination ONC201 and radiation therapy in the treatment of breast cancer by Jhawar, Sachin R., Schiff, Devora, Wu, Hao, Thandoni, Aditya, Hassan, Suemair, Allen, Joshua, Stogniew, Martin, Tarapore, Rohinton, Oster, Wolfgang, Stein, Mark, Silk, Ann W., Goyal, Sharad, Haffty, Bruce G., Zloza, Andrew

“…Abstract Purpose: Metastatic breast cancer patients continue to have poor outcomes on current treatments, and thus, novel therapies in combination with…”
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Riluzole Enhances Ionizing Radiation-Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo by KHAN, Atif J, WALL, Brian, AHLAWAT, Stuti, GREEN, Camille, SCHIFF, Devora, MEHNERT, Janice M, GOYDOS, James S, CHEN, Suzie, HAFFTY, Bruce G

“…Brain metastases are a common preterminal event in patients with metastatic melanoma and require radiation therapy. Our group has previously shown that human…”
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Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells by Wall, Brian A., Wangari-Talbot, Janet, Shin, Seung S., Schiff, Devora, Sierra, Jairo, Yu, Lumeng J., Khan, Atif, Haffty, Bruce, Goydos, James S., Chen, Suzie

“…Summary Gain of function of the neuronal receptor, metabotropic glutamate receptor 1 (Grm1), was sufficient to induce melanocytic transformation in vitro and…”
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Mediator of DNA damage checkpoint protein 1 (MDC1) expression as a prognostic marker for nodal recurrence in early-stage breast cancer patients treated with breast-conserving surgery and radiation therapy by Patel, Akshar N, Goyal, Sharad, Wu, Hao, Schiff, Devora, Moran, Meena S, Haffty, Bruce G

“…The mediator of DNA damage checkpoint protein 1 (MDC1) regulates cell cycle checkpoints and recruits repair proteins to sites of double-stranded DNA damage…”
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Low p53 Binding Protein 1 (53BP1) Expression Is Associated With Increased Local Recurrence in Breast Cancer Patients Treated With Breast-Conserving Surgery and Radiotherapy by Neboori, Hanmanth J.R., BS, Haffty, Bruce G., MD, Wu, Hao, MD, PhD, Yang, Qifeng, MD, PhD, Aly, Amal, PhD, Goyal, Sharad, MD, Schiff, Devora, Moran, Meena S., MD, Golhar, Ryan, PhD, Chen, Chunxia, MS, Moore, Dirk, PhD, Ganesan, Shridar, MD, PhD

“…Purpose To investigate whether the expression of p53 binding protein 1 (53BP1) has prognostic significance in a cohort of early-stage breast cancer patients…”
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Abstract 2489: Targeting pro-survival BCL-2 family members increases radiation sensitivity in breast cancer cells by Wu, Hao, Schiff, Devora S., Goyal, Sharad, Neboori, Hanmanth J.R., Haffty, Bruce G.

“…Abstract In previous studies we have shown that BCL-2 expression was associated with an increased risk of local recurrence in patients with early stage breast…”
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Disruption of GRM 1‐mediated signalling using riluzole results in DNA damage in melanoma cells by Wall, Brian A., Wangari‐Talbot, Janet, Shin, Seung S., Schiff, Devora, Sierra, Jairo, Yu, Lumeng J., Khan, Atif, Haffty, Bruce, Goydos, James S., Chen, Suzie

“…Summary Gain of function of the neuronal receptor, metabotropic glutamate receptor 1 ( G rm1), was sufficient to induce melanocytic transformation in vitro and…”
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CD8+, Radiosensitive T Cells of Parental Origin, Oppose Cells Capable of Down-Regulating Cytotoxicity in Murine Acute Lethal Graft-versus-Host Disease by Mann, Richard A., Schiff, Devora, Jetzt, Amanda E., Ron, Yacov, Singh, Manjeet, Singh, Ajay B.

“…Murine graft-versus-host (GVH) disease takes two forms depending upon the parental/F1 strain combination employed. Anemia, lymphopenia, hypogammaglobulinemia,…”
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