Search Results - "Schiestl, R. H."

Genotoxicity profiles of common alkyl halides and esters with alkylating activity by Sobol, Z., Engel, M.E., Rubitski, E., Ku, W.W., Aubrecht, J., Schiestl, R.H.

“…Drug synthesis and/or formulation can generate genotoxic impurities. For instance, strong acid/alcohol interactions during the process of drug salt formation…”
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Mitochondrial Respiratory Electron Carriers Are Involved in Oxidative Stress during Heat Stress in Saccharomyces cerevisiae by Davidson, John F., Schiestl, Robert H.

“…In the present study we sought to determine the source of heat-induced oxidative stress. We investigated the involvement of mitochondrial respiratory electron…”
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X Radiation Causes a Persistent Induction of Reactive Oxygen Species and a Delayed Reinduction of TP53 in Normal Human Diploid Fibroblasts by Rugo, R. E., Secretan, M. B., Schiestl, R. H.

“…Rugo, R. E., Secretan, M. B. and Schiestl, R. H. X Radiation Causes a Persistent Induction of Reactive Oxygen Species and a Delayed Reinduction of TP53 in…”
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Improved method for high efficiency transformation of intact yeast cells by Gietz, Daniel, Jean, Andrew St, Woods, Robin A., Schiestl, Robert H.

“…We describe further improvements and streamlining of this method, yielding reproducibly 10 super(6) transformants per microgram of vector DNA, a ten fold…”
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Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae by Davidson, J.F. (Burns Philip Research and Development Pty. Ltd., North Ryde, NSW, Australia.), Whyte, B, Bissinger, P.H, Schiestl, R.H

“…The cause for death after lethal heat shock is not well understood. A shift from low to intermediate temperature causes the induction of heat-shock proteins in…”
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Integration of DNA fragments by illegitimate recombination in Saccharomyces cerevisiae by Schiestl, R.H. (University of North Carolina, Chapel Hill, NC), Petes, T.D

“…DNA fragments (generated by BamHI treatment) with no homology to the yeast genome were transformed into Saccharomyces cerevisiae. When the fragments were…”
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RAD1, an excision repair gene of Saccharomyces cerevisiae, is also involved in recombination by Schiestl, R H, Prakash, S

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Cytotoxic and Genotoxic Consequences of Heat Stress Are Dependent on the Presence of Oxygen in Saccharomyces cerevisiae by Davidson, J F, Schiestl, R H

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Homologous recombination as a mechanism for genome rearrangements : environmental and genetic effects by BISHOP, Alexander J. R, SCHIESTL, Robert H

“…Novel findings over the last 2 years have led to an increased emphasis on homologous recombination (HR) as both a pathway for DNA repair and a cause for…”
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Topoisomerase I involvement in illegitimate recombination in Saccharomyces cerevisiae by Zhu, Jie, Schiestl, Robert H.

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High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier by Schiestl, R.H, Gietz, R.D

“…A method, using LiAc to yield competent cells, is described that increased the efficiency of genetic transformation of intact cells of Saccharomyces cerevisiae…”
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p21 controls patterning but not homologous recombination in RPE development by Bishop, A.J.R., Kosaras, B., Hollander, M.C., Fornace, A., Sidman, R.L., Schiestl, R.H.

“…p21/WAF1/CIP1/MDA6 is a key cell cycle regulator. Cell cycle regulation is an important part of development, differentiation, DNA repair and apoptosis…”
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Human topoisomerase I mediates illegitimate recombination leading to DNA insertion into the ribosomal DNA locus in Saccharomyces cerevisiae by Zhu, J, Schiestl, R H

“…Eukaryotic type I DNA topoisomerases catalyze the relaxation of supercoiled DNA, and play a critical role in DNA replication, transcription and recombination…”
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Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice by BISHOP, A. J. R, BARLOW, C, WYNSHAW-BORIS, A. J, SCHIESTL, R. H

“…Ataxia telangiectasia (AT) patients have inactivating mutations in both copies of the ATM gene. The ATM protein that the gene encodes is involved in DNA…”
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RAD10, an excision repair gene of Saccharomyces cerevisiae, is involved in the RAD1 pathway of mitotic recombination by SCHIESTL, R. H, PRAKASH, S

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Susceptibility of proliferating cells to benzo[a]pyrene-induced homologous recombination in mice by Bishop, A.J.R., Kosaras, B., Carls, N., Sidman, R.L., Schiestl, R.H.

“…The pink-eyed unstable mutation, pun, is the result of a 70 kb tandem duplication within the murine pink-eyed, p, gene. Deletion of one copy of the duplicated…”
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Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae by Schiestl, R H, Zhu, J, Petes, T D

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Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assay by Secretan, M B, Scuric, Z, Oshima, J, Bishop, A J R, Howlett, N G, Yau, D, Schiestl, R H

“…In mammalian cells, DNA double-strand breaks are repaired by non-homologous end-joining and homologous recombination, both pathways being essential for the…”
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Aniline and its metabolites generate free radicals in yeast by Brennan, R.J., Schiestl, R.H.

“…The carcinogen aniline is negative in the Ames Salmonella mutagenicity assay. Aniline does, however, induce intrachromosomal recombination between repeated…”
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Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier by Gietz, R D, Schiestl, R H

“…The highly efficient yeast lithium acetate transformation protocol of Schiestl and Gietz (1989) was tested for its applicability to some of the most important…”
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