Search Results - "Schiestl, R."

Intestinal bacterial indicator phylotypes convey radiation-induced genotoxicity by Maier, I, Liu, J, Borneman, J, Schiestl, R

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Grand Challenge: Applying Regulatory Science and Big Data to Improve Medical Device Innovation by Erdman, Arthur G., Keefe, Daniel F., Schiestl, Randall

“…Understanding how proposed medical devices will interface with humans is a major challenge that impacts both the design of innovative new devices and approval…”
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Mitochondrial Respiratory Electron Carriers Are Involved in Oxidative Stress during Heat Stress in Saccharomyces cerevisiae by Davidson, John F., Schiestl, Robert H.

“…In the present study we sought to determine the source of heat-induced oxidative stress. We investigated the involvement of mitochondrial respiratory electron…”
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Genotoxicity profiles of common alkyl halides and esters with alkylating activity by Sobol, Z., Engel, M.E., Rubitski, E., Ku, W.W., Aubrecht, J., Schiestl, R.H.

“…Drug synthesis and/or formulation can generate genotoxic impurities. For instance, strong acid/alcohol interactions during the process of drug salt formation…”
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Improved method for high efficiency transformation of intact yeast cells by Gietz, Daniel, Jean, Andrew St, Woods, Robin A., Schiestl, Robert H.

“…We describe further improvements and streamlining of this method, yielding reproducibly 10 super(6) transformants per microgram of vector DNA, a ten fold…”
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Genetic Modification of Mouse Bone Marrow by Lentiviral Vector-Mediated Delivery of Hypoxanthine-Guanine Phosphoribosyltransferase Short Hairpin RNA Confers Chemoprotection Against 6-Thioguanine Cytotoxicity by Hacke, K, Treger, J.A, Bogan, B.T, Schiestl, R.H, Kasahara, N

“…Abstract We have recently developed a novel and highly efficient strategy that exclusively uses the purine analog 6-thioguanine (6TG) for both…”
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X Radiation Causes a Persistent Induction of Reactive Oxygen Species and a Delayed Reinduction of TP53 in Normal Human Diploid Fibroblasts by Rugo, R. E., Secretan, M. B., Schiestl, R. H.

“…Rugo, R. E., Secretan, M. B. and Schiestl, R. H. X Radiation Causes a Persistent Induction of Reactive Oxygen Species and a Delayed Reinduction of TP53 in…”
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Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae by Davidson, J.F. (Burns Philip Research and Development Pty. Ltd., North Ryde, NSW, Australia.), Whyte, B, Bissinger, P.H, Schiestl, R.H

“…The cause for death after lethal heat shock is not well understood. A shift from low to intermediate temperature causes the induction of heat-shock proteins in…”
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Characterization and in vitro biological effects of concentrated particulate matter from Mexico City by De Vizcaya-Ruiz, A., Gutiérrez-Castillo, M.E., Uribe-Ramirez, M., Cebrián, M.E., Mugica-Alvarez, V., Sepúlveda, J., Rosas, I., Salinas, E., Garcia-Cuéllar, C., Martínez, F., Alfaro-Moreno, E., Torres-Flores, V., Osornio-Vargas, A., Sioutas, C., Fine, P.M., Singh, M., Geller, M.D., Kuhn, T., Miguel, A.H., Eiguren-Fernandez, A., Schiestl, R.H., Reliene, R., Froines, J.

“…Coarse and fine particles were collected using an ambient particle concentrator (VACES system) in the north, center and south regions of Mexico City during May…”
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Cytotoxic and Genotoxic Consequences of Heat Stress Are Dependent on the Presence of Oxygen in Saccharomyces cerevisiae by Davidson, J F, Schiestl, R H

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Homologous recombination as a mechanism for genome rearrangements : environmental and genetic effects by BISHOP, Alexander J. R, SCHIESTL, Robert H

“…Novel findings over the last 2 years have led to an increased emphasis on homologous recombination (HR) as both a pathway for DNA repair and a cause for…”
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High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier by Schiestl, R.H, Gietz, R.D

“…A method, using LiAc to yield competent cells, is described that increased the efficiency of genetic transformation of intact cells of Saccharomyces cerevisiae…”
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Integration of DNA fragments by illegitimate recombination in Saccharomyces cerevisiae by Schiestl, R.H. (University of North Carolina, Chapel Hill, NC), Petes, T.D

“…DNA fragments (generated by BamHI treatment) with no homology to the yeast genome were transformed into Saccharomyces cerevisiae. When the fragments were…”
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Human topoisomerase I mediates illegitimate recombination leading to DNA insertion into the ribosomal DNA locus in Saccharomyces cerevisiae by Zhu, J, Schiestl, R H

“…Eukaryotic type I DNA topoisomerases catalyze the relaxation of supercoiled DNA, and play a critical role in DNA replication, transcription and recombination…”
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Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice by BISHOP, A. J. R, BARLOW, C, WYNSHAW-BORIS, A. J, SCHIESTL, R. H

“…Ataxia telangiectasia (AT) patients have inactivating mutations in both copies of the ATM gene. The ATM protein that the gene encodes is involved in DNA…”
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Topoisomerase I involvement in illegitimate recombination in Saccharomyces cerevisiae by Zhu, Jie, Schiestl, Robert H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RAD1, an excision repair gene of Saccharomyces cerevisiae, is also involved in recombination by Schiestl, R H, Prakash, S

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assay by Secretan, M B, Scuric, Z, Oshima, J, Bishop, A J R, Howlett, N G, Yau, D, Schiestl, R H

“…In mammalian cells, DNA double-strand breaks are repaired by non-homologous end-joining and homologous recombination, both pathways being essential for the…”
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Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier by Gietz, R D, Schiestl, R H

“…The highly efficient yeast lithium acetate transformation protocol of Schiestl and Gietz (1989) was tested for its applicability to some of the most important…”
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p21 controls patterning but not homologous recombination in RPE development by Bishop, A.J.R., Kosaras, B., Hollander, M.C., Fornace, A., Sidman, R.L., Schiestl, R.H.

“…p21/WAF1/CIP1/MDA6 is a key cell cycle regulator. Cell cycle regulation is an important part of development, differentiation, DNA repair and apoptosis…”
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