Search Results - "Schiemann, W. P."

Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression by Wendt, M K, Smith, J A, Schiemann, W P

“…Transforming growth factor-β (TGF-β) and epidermal growth factor (EGF) have critical roles in regulating the metastasis of aggressive breast cancers, yet the…”
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Precise targeting of cancer metastasis using multi-ligand nanoparticles incorporating four different ligands by Peiris, P M, He, F, Covarrubias, G, Raghunathan, S, Turan, O, Lorkowski, M, Gnanasambandam, B, Wu, C, Schiemann, W P, Karathanasis, E

“…Metastasis displays a highly heterogeneous cellular population with cancer cells continuously evolving. As a result, a single-ligand nanoparticle cannot…”
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Role of Transforming Growth Factor β in Human Disease by Blobe, Gerard C, Schiemann, William P, Lodish, Harvey F

“…In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular…”
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TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer by Wendt, M K, Schiemann, B J, Parvani, J G, Lee, Y-H, Kang, Y, Schiemann, W P

“…Epithelial-mesenchymal transition (EMT) programs are essential in promoting breast cancer invasion, systemic dissemination and in arousing proliferative…”
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A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by transforming growth factor β in a cutaneous T-cell lymphoma by SCHIEMANN, W. P, PFEIFER, W. M, LEVI, E, KADIN, M. E, LODISH, H. F

“…Spontaneous regression of skin lesions is characteristic of lymphomatoid papulosis (LyP), a clonal cutaneous lymphoproliferative disorder. A minority of LyP…”
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Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways by SCHIEMANN, W. P, NATHANSON, N. M

“…We show here that treatment of 3T3-L1 cells with leukemia inhibitory factor (LIF) stimulates the activation of mitogen-activated protein kinase kinase (MAPKK),…”
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TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation by Weinberg, Robert A, Perlman, Riki, Schiemann, William P, Brooks, Mary W, Lodish, Harvey F

“…Transforming growth factor-beta (TGF-beta) is a multifunctional growth factor that has a principal role in growth control through both its cytostatic effect on…”
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Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-β by Xiao, Yi Qun, Malcolm, Ken, Worthen, G. Scott, Gardai, Shyra, Schiemann, William P., Fadok, Valerie A., Bratton, Donna L., Henson, Peter M.

“…Phagocytosis of apoptotic cells by macrophages results in the production of transforming growth factor-β (TGF-β), which plays an important role in induction of…”
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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades by Schiemann, William P, Blobe, Gerard C, Kalume, Dario E, Pandey, Akhilesh, Lodish, Harvey F

“…Fibulin-5 (FBLN-5; also known as DANCE or EVEC) is an integrin-binding extracellular matrix protein that mediates endothelial cell adhesion; it is also a…”
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Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells by Albig, Allan R, Schiemann, William P

“…Fibulin-5 (FBLN-5) is a widely expressed, integrin-binding extracellular matrix protein that mediates endothelial cell adhesion and scaffolds cells to elastic…”
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Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-  through a PGE2-dependent mechanisms by Neil, J. R., Johnson, K. M., Nemenoff, R. A., Schiemann, W. P.

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Action of adenosine in estrogen-primed nonpregnant guinea pig myometrium: characterization of the smooth muscle receptor and coupling to phosphoinositide metabolism by Schiemann, W P, Doggwiler, K O, Buxton, I L

“…The smooth muscle of guinea pig uterus is contracted by adenosine in a manner consistent with the presence of a purine nucleoside receptor of the P1-A1 subtype…”
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Phosphorylation of the Human Leukemia Inhibitory Factor (LIF) Receptor by Mitogen-Activated Protein Kinase and the Regulation of LIF Receptor Function by Heterologous Receptor Activation by Schiemann, William P., Graves, Lee M., Baumann, Heinz, Morella, Karen K., Gearing, David P., Nielsen, Mark D., Krebs, Edwin G., Nathanson, Neil M.

“…We used a bacterially expressed fusion protein containing the entire cytoplasmic domain of the human leukemia inhibitory factor (LIF) receptor to study its…”
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Raf-1 independent stimulation of mitogen-activated protein kinase by leukemia inhibitory factor in 3T3-L1 cells by SCHIEMANN, W. P, NATHANSON, N. M

“…We show here that treatment of 3T3-L1 cells with leukemia inhibitory factor (LIF) stimulated Raf-1 activity in a time- and dose-dependent manner. Although…”
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Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling by Blobe, G C, Schiemann, W P, Pepin, M C, Beauchemin, M, Moustakas, A, Lodish, H F, O'Connor-McCourt, M D

“…Transforming growth factor beta (TGF-beta) signals through three high affinity cell surface receptors, TGF-beta type I, type II, and type III receptors. The…”
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Smooth muscle adenosine A1 receptors couple to disparate effectors by distinct G proteins in pregnant myometrium by Schiemann, W P, Westfall, D P, Buxton, I L

“…We have previously shown that adenosine, acting at an A1 receptor, contracts the smooth muscle of virgin guinea pig uterus (M. A. Smith, I. L. O. Buxton, and…”
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Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-  in mammary epithelial cells via a MMP-dependent mechanism by Lee, Y.-H., Albig, A. R., Regner, M., Schiemann, B. J., Schiemann, W. P.

“…Epithelial-mesenchymal transition (EMT) is a normal physiological process that regulates tissue development, remodeling and repair; however, aberrant EMT also…”
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On the ability of endogenous adenosine to regulate purine nucleoside receptor binding of antagonists in smooth muscle membranes by Schiemann, W P, Walther, J M, Buxton, I L

“…Adenosine, acting at A1 and A2 purine nucleoside receptors, regulates the physiology of many tissues. Myometrial smooth muscle from pregnant guinea pigs, which…”
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Adenosine A1-receptor coupling to phosphoinositide metabolism in pregnant guinea pig myometrium by Schiemann, W P, Buxton, I L

“…Adenosine contracts pregnant and nonpregnant guinea pig myometrial smooth muscle (MSM). We have 1) described dissociation of A1-adenosine receptors from…”
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Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras by Schiemann, W P, Bartoe, J L, Nathanson, N M

“…Chimeric receptors containing the entire or various cytoplasmic domains of either gp130 or leukemia inhibitory factor receptor alpha (LIFR) were used to…”
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