Search Results - "Schiedel, M."

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins by Falenczyk, C., Schiedel, M., Karaman, B., Rumpf, T., Kuzmanovic, N., Grøtli, M., Sippl, W., Jung, M., König, B.

“…Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore…”
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Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration by Vogelmann, A, Schiedel, M, Wössner, N, Merz, A, Herp, D, Hammelmann, S, Colcerasa, A, Komaniecki, G, Hong, JY, Sum, M, Metzger, E, Neuwirt, E, Zhang, L, Einsle, O, Groß, O, Schüle, R, Lin, H, Sippl, W, Jung, M

“…Sirtuin2 (Sirt2) with its NAD + -dependent deacetylase and defatty-acylase activities plays a central role in the regulation of specific cellular functions…”
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Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by Schiedel, M, Fallarero, A, Luise, C, Sippl, W, Vuorela, P, Jung, M

“…By analogy with the natural product chelerythrine, which has been identified as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase…”
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How precise is the PRECICE compared to the ISKD in intramedullary limb lengthening? by Schiedel, Frank M, Vogt, Björn, Tretow, Henning L, Schuhknecht, Britta, Gosheger, Georg, Horter, Melanie J, Rödl, Robert

“…Background and purpose - The PRECICE intramedullary limb lengthening system uses a new technique with a magnetic rod and a motorized external remote controller…”
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Publication Rate of Abstracts Presented at European Paediatric Orthopaedic Society Annual Meetings, 2006 to 2008 by Kleine-Konig, Marie-Theres, Schulte, Tobias L, Gosheger, Georg, Rödl, Robert, Schiedel, Frank M

“…BACKGROUND:The quality of the abstracts presented at a conference reflects the scientific work and level of activity of the scientific association concerned…”
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Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals) by Schiedel, Matthias, Herp, Daniel, Hammelmann, Sören, Swyter, Sören, Lehotzky, Attila, Robaa, Dina, Oláh, Judit, Ovádi, Judit, Sippl, Wolfgang, Jung, Manfred

“…Here we report the development of a proteolysis targeting chimera (PROTAC) based on the combination of the unique features of the sirtuin rearranging ligands…”
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Evaluation of the SMALL nail: Drive technology and behavior in situ by Dünnweber, L.H, Rödl, R, Gosheger, G, Schiedel, F.M

“…Highlights • An intramedullary lengthening nail with a shape memory alloy (SMA) element as drive was constructed. • Transcutaneous induced electromagnetical…”
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Estimation of Patient Dose and Associated Radiogenic Risks from Limb Lengthening by Schiedel, Frank M., Buller, Tim C., Rödl, Robert

“…Limb-lengthening procedures include a series of radiographic examinations to follow the lengthening process and callus formation. We quantified ionizing…”
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Intramedullary limb lengthening with the Intramedullary Skeletal Kinetic Distractor in the lower limb by SCHIEDEL, F. M, PIP, S, WACKER, S, POPPING, J, TRETOW, H, LEIDINGER, B, RÖDL, R

“…We report the results of intramedullary leg lengthening conducted between 2002 and 2009 using the Intramedullary Skeletal Kinetic Distractor in 69 unilateral…”
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Dieterich's Disease--the rare aseptic necrosis of the metacarpal head by Schiedel, F M, Langer, M

“…The rare diagnosis of the Dieterich's disease at the head of the metacarpal III is presented on the case of a 19-year-old female patient. While aseptic bone…”
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Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)The authors declare no competing interests.Electronic supplementary information (ESI) available: All the experimental details, NMR spectra, MS and HPLC analysis results. See DOI: 10.1039/c6md00647g by Schiedel, M, Fallarero, A, Luise, C, Sippl, W, Vuorela, P, Jung, M

“…By analogy with the natural product chelerythrine, which has been identified as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase…”
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Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: All the experimental details, NMR spectra, MS and HPLC analysis results. See DOI: 10.1039/c6md00647g by Schiedel, M., Fallarero, A., Luise, C., Sippl, W., Vuorela, P., Jung, M.

“…Discovery of 8-hydroxy-2,7-naphthyridinium salts as a novel class of cholinesterase inhibitors inspired by the natural product chelerythrine. By analogy with…”
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Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuinsElectronic supplementary information (ESI) available: Detailed experimental procedures of the synthesis of 3 and 11, additional spectral data, photochemical measurements, biological data and docking studies of 2, 3 and 11. See DOI: 10.1039/c4sc01346h by Falenczyk, C, Schiedel, M, Karaman, B, Rumpf, T, Kuzmanovic, N, Grøtli, M, Sippl, W, Jung, M, König, B

“…Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore…”
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Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni by Schiedel, Matthias, Marek, Martin, Lancelot, Julien, Karaman, Berin, Almlöf, Ingrid, Schultz, Johan, Sippl, Wolfgang, Pierce, Raymond J, Romier, Christophe, Jung, Manfred

“…Sirtuins are NAD(+)-dependent histone deacetylases (HDACs) that cleave off acetyl but also other acyl groups from the ϵ-amino group of lysines in histones and…”
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Single-Compound Libraries of Organic Materials: Parallel Synthesis and Screening of Fluorescent Dyes by Schiedel, Marc-Steffen, Briehn, Christoph A., Bäuerle, Peter

“…“Hits” with high quantum yields: The screening of the chromophores of a coumarin library for optical properties allowed the identification of “hits” with high…”
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How precise is the PRECICE compared to the ISKD in intramedullary limb lengthening?: Reliability and safety in 26 procedures by Schiedel, Frank M, Vogt, Björn, Tretow, Henning L, Schuhknecht, Britta, Gosheger, Georg, Horter, Melanie J, Rödl, Robert

“…Background and purpose - The PRECICE intramedullary limb lengthening system uses a new technique with a magnetic rod and a motorized external remote controller…”
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Single-Compound Libraries of Organic Materials: From the Combinatorial Synthesis of Conjugated Oligomers to Structure-Property Relationships by Briehn, Christoph A., Schiedel, Marc-Steffen, Bonsen, Eva M., Schuhmann, Wolfgang, Bäuerle, Peter

“…256 oligomers make up the quaterthiophene library of compounds 1 which was prepared by a combination of parallel and “mix‐and‐split” syntheses. An automated…”
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CC Cross-coupling reactions for the combinatorial synthesis of novel organic materials by Schiedel, Marc-Steffen, Briehn, Christoph A, Bäuerle, Peter

“…To accelerate the development process to organic materials combinatorial strategies and screening methodologies have been representatively elaborated for…”
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The Alkaloid Patterns of Cell Suspension Cultures and Differentiated Plants of Baptisia Australis and Their Biogenetic Implications by Wink, M, Hartmann, T, Witte, L, Schiebel, H. M

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