Diphenyl diselenide supplementation reduces biochemical alterations associated with oxidative stress in rats fed with fructose and hydrochlorothiazide

•Treatment with Hydrochlorothiazide (HCTZ) altered both glycemic and lipid profile.•High fructose diet (HFD) exaggerates metabolic end points of biochemical toxicity.•Consumption of HFD and HCTZ results in oxidative stress.•The use of HFD and HCTZ results in hypokalemia and hypomagnesemia.•Diphenyl...

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Published in:	Chemico-biological interactions Vol. 204; no. 3; pp. 191 - 199
Main Authors:	Ribeiro, Marinei Cristina Pereira, Ávila, Daiana Silva, Schiar, Viviane Patrícia Pires, Santos, Danúbia Bonfanti dos, Meinerz, Daiane F., Duarte, Marta Medeiros Frescura, Monteiro, Roger, Puntel, Robson, de Bem, Andreza Fabro, Hassan, Waseem, de Vargas Barbosa, Nilda Berenice, Rocha, João Batista Teixeira
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 25-08-2013
Subjects:	animal models Animals antioxidants Antioxidants - pharmacology ascorbic acid Benzene Derivatives - pharmacology biphenyl blood glucose catalase Catalase - metabolism cholesterol Diet Dietary Supplements Diphenyl diselenide Down-Regulation - drug effects fructose Fructose - metabolism High fructose diet Hydrochlorothiazide Hydrochlorothiazide - metabolism hypertriglyceridemia hypomagnesemia ingestion lipid peroxidation Male Organoselenium Compounds - pharmacology Oxidative stress Oxidative Stress - drug effects potassium Rats Rats, Wistar superoxide dismutase triacylglycerols Diphenyl diselenide Oxidative stress Hydrochlorothiazide High fructose diet
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Summary:	•Treatment with Hydrochlorothiazide (HCTZ) altered both glycemic and lipid profile.•High fructose diet (HFD) exaggerates metabolic end points of biochemical toxicity.•Consumption of HFD and HCTZ results in oxidative stress.•The use of HFD and HCTZ results in hypokalemia and hypomagnesemia.•Diphenyl Diselenide supplementation reduced oxidative damage. The study evaluated whether a diet containing diphenyl diselenide (PhSe)2, a synthetic antioxidant, could reduce the biochemical alterations induced by chronic consumption of highly enriched fructose diet and/or hydrochlorothiazide (HCTZ). Rats were fed a control diet (CT) or a high fructose diet (HFD), supplemented with or not HCTZ (4.0g/kg) and/or (PhSe)2 (3ppm) for 18weeks. HFD intake increased significantly plasma glucose, fructosamine, triglycerides and cholesterol levels. (PhSe)2 supplementation significantly reduced triglycerides and cholesterol but could not restore them to control levels. The combination of HFD and HCTZ significantly altered plasma glucose, fructosamine, triglycerides and cholesterol levels which were not restore by (PhSe)2 supplementation. Lipid peroxidation, protein carbonyl formation, vitamin C level and catalase activity decreased after HFD, HCTZ or HFD plus HCTZ ingestion. Remarkably (PhSe)2 supplementation restored the oxidative stress parameters. HCTZ decreased renal superoxide dismutase (SOD) activity, which was restored to control levels by (PhSe)2. Furthermore, the association of HFD and HCTZ decreased plasma potassium levels and aggravated HCTZ-induced hypomagnesemia and hypertriglyceridemia. Here we provided evidence of the involvement of oxidative stress and metabolic disorders in a rat model of HFD associated or not with HTCZ. (PhSe)2 supplementation reduced the oxidative stress and this compound should be considered for the treatment of biochemical disturbances and oxidative stress in other animal models of metabolic disorders.
Bibliography:	http://dx.doi.org/10.1016/j.cbi.2013.05.008 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-2797 1872-7786
DOI:	10.1016/j.cbi.2013.05.008