Search Results - "Schey, L."

Proteomics characterization of exosome cargo by Schey, Kevin L., Luther, J. Matthew, Rose, Kristie L.

“…•Rationale for defining exosome protein cargo is presented.•Methods for global exosome protein identification are described.•Quantitative proteomics methods,…”
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Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP by Guo, G., Papanicolaou, M., Demarais, N. J., Wang, Z., Schey, K. L., Timpson, P., Cox, T. R., Grey, A. C.

“…Spatial proteomics has the potential to significantly advance our understanding of biology, physiology and medicine. Matrix-assisted laser…”
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Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT) by Wang, Zhen, Hill, Salisha, Luther, James M., Hachey, David L., Schey, Kevin L.

“…Exosomes are membrane vesicles that are secreted by cells upon fusion of multivesicular bodies with the plasma membrane. Exosomal proteomics has emerged as a…”
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Changes to Zonular Tension Alters the Subcellular Distribution of AQP5 in Regions of Influx and Efflux of Water in the Rat Lens by Petrova, Rosica S, Bavana, Nandini, Zhao, Rusin, Schey, Kevin L, Donaldson, Paul J

“…The lens uses circulating fluxes of ions and water that enter the lens at both poles and exit at the equator to maintain its optical properties. We have mapped…”
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Aquaporins in the eye: Expression, function, and roles in ocular disease by Schey, Kevin L., Wang, Zhen, L. Wenke, Jamie, Qi, Ying

“…All thirteen known mammalian aquaporins have been detected in the eye. Moreover, aquaporins have been identified as playing essential roles in ocular functions…”
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MALDI (matrix assisted laser desorption ionization) Imaging Mass Spectrometry (IMS) of skin: Aspects of sample preparation by de Macedo, Cristiana Santos, Anderson, David M., Schey, Kevin L.

“…MALDI (matrix assisted laser desorption ionization) Imaging Mass Spectrometry (IMS) allows molecular analysis of biological materials making possible the…”
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Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium by Ablonczy, Zsolt, Higbee, Daniel, Anderson, David M, Dahrouj, Mohammad, Grey, Angus C, Gutierrez, Danielle, Koutalos, Yiannis, Schey, Kevin L, Hanneken, Anne, Crouch, Rosalie K

“…The accumulation of lipofuscin in the RPE is a hallmark of aging in the eye. The best characterized component of lipofuscin is A2E, a bis-retinoid byproduct of…”
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Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling by Sierra, Johanna C., Piazuelo, M. Blanca, Luis, Paula B., Barry, Daniel P., Allaman, Margaret M., Asim, Mohammad, Sebrell, Thomas A., Finley, Jordan L., Rose, Kristie L., Hill, Salisha, Holshouser, Steven L., Casero, Robert A., Cleveland, John L., Woster, Patrick M., Schey, Kevin L., Bimczok, Diane, Schneider, Claus, Gobert, Alain P., Wilson, Keith T.

“…Helicobacter pylori infection is the main risk factor for the development of gastric cancer, the third leading cause of cancer death worldwide. H. pylori…”
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Modulation of Membrane Trafficking of AQP5 in the Lens in Response to Changes in Zonular Tension Is Mediated by the Mechanosensitive Channel TRPV1 by Petrova, Rosica S, Nair, Nikhil, Bavana, Nandini, Chen, Yadi, Schey, Kevin L, Donaldson, Paul J

“…In mice, the contraction of the ciliary muscle via the administration of pilocarpine reduces the zonular tension applied to the lens and activates the…”
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Spontaneous cross-linking of proteins at aspartate and asparagine residues is mediated via a succinimide intermediate by Friedrich, Michael G, Wang, Zhen, Schey, Kevin L, Truscott, Roger J W

“…The breakdown of long-lived proteins (LLPs) is associated with aging, as well as disease; however, our understanding of the molecular processes involved is…”
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High Resolution MALDI Imaging Mass Spectrometry of Retinal Tissue Lipids by Anderson, David M. G., Ablonczy, Zsolt, Koutalos, Yiannis, Spraggins, Jeffrey, Crouch, Rosalie K., Caprioli, Richard M., Schey, Kevin L.

“…Matrix assisted laser desorption ionization imaging mass spectrometry (MALDI IMS) has the ability to provide an enormous amount of information on the…”
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Insight into the Mammalian Aquaporin Interactome by Törnroth-Horsefield, Susanna, Chivasso, Clara, Strandberg, Helin, D'Agostino, Claudia, O'Neale, Carla V T, Schey, Kevin L, Delporte, Christine

“…Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across…”
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Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori-induced inflammation-driven gastric carcinogenesis by Noto, Jennifer M, Piazuelo, M Blanca, Shah, Shailja C, Romero-Gallo, Judith, Hart, Jessica L, Di, Chao, Carmichael, James D, Delgado, Alberto G, Halvorson, Alese E, Greevy, Robert A, Wroblewski, Lydia E, Sharma, Ayushi, Newton, Annabelle B, Allaman, Margaret M, Wilson, Keith T, Washington, M Kay, Calcutt, M Wade, Schey, Kevin L, Cummings, Bethany P, Flynn, Charles R, Zackular, Joseph P, Peek, Jr, Richard M

“…Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host, and environmental factors. Here, we demonstrate that H. pylori…”
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Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion by Qi, Ying, Wang, Xiaojing, Rose, Kristie L, MacDonald, W Hayes, Zhang, Bing, Schey, Kevin L, Luther, James M

“…Urinary exosomes secreted by multiple cell types in the kidney may participate in intercellular signaling and provide an enriched source of kidney-specific…”
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Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates by Wang, Zhen, Lyons, Brian, Truscott, Roger J. W., Schey, Kevin L.

“…Summary Nonenzymatic post‐translational modification (PTM) of proteins is a fundamental molecular process of aging. The combination of various modifications…”
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Proteomics and phosphoproteomics analysis of human lens fiber cell membranes by Wang, Zhen, Han, Jun, David, Larry L, Schey, Kevin L

“…The human lens fiber cell insoluble membrane fraction contains important membrane proteins, cytoskeletal proteins, and cytosolic proteins that are strongly…”
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The Role of Aquaporins in Ocular Lens Homeostasis by Schey, Kevin L, Petrova, Rosica S, Gletten, Romell B, Donaldson, Paul J

“…Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens homeostasis, contribute to the establishment and maintenance of the overall…”
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Computational Structure Prediction for Antibody-Antigen Complexes From Hydrogen-Deuterium Exchange Mass Spectrometry: Challenges and Outlook by Tran, Minh H, Schoeder, Clara T, Schey, Kevin L, Meiler, Jens

“…Although computational structure prediction has had great successes in recent years, it regularly fails to predict the interactions of large protein complexes…”
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Lens Aquaporins in Health and Disease: Location is Everything by Schey, Kevin L, Gletten, Romell B, O'Neale, Carla V T, Wang, Zhen, Petrova, Rosica S, Donaldson, Paul J

“…Cataract and presbyopia are the leading cause of vision loss and impaired vision, respectively, worldwide. Changes in lens biochemistry and physiology with age…”
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MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase by Schey, Garrett L, Buttery, Peter H, Hildebrandt, Emily R, Novak, Sadie X, Schmidt, Walter K, Hougland, James L, Distefano, Mark D

“…Protein farnesylation is a post-translational modification where a 15-carbon farnesyl isoprenoid is appended to the C-terminal end of a protein by…”
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