Search Results - "Scheveneels, Wendy"

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease by Benoy, Veronick, Van Helleputte, Lawrence, Prior, Robert, d'Ydewalle, Constantin, Haeck, Wanda, Geens, Natasja, Scheveneels, Wendy, Schevenels, Begga, Cader, M Zameel, Talbot, Kevin, Kozikowski, Alan P, Vanden Berghe, Pieter, Van Damme, Philip, Robberecht, Wim, Van Den Bosch, Ludo

“…Patients with Charcot-Marie-Tooth disease with predominant axonal loss (CMT2) show extensive genetic heterogeneity. Benoy et al. demonstrate a link between…”
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Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD by Boeynaems, Steven, Bogaert, Elke, Michiels, Emiel, Gijselinck, Ilse, Sieben, Anne, Jovičić, Ana, De Baets, Greet, Scheveneels, Wendy, Steyaert, Jolien, Cuijt, Ivy, Verstrepen, Kevin J., Callaerts, Patrick, Rousseau, Frederic, Schymkowitz, Joost, Cruts, Marc, Van Broeckhoven, Christine, Van Damme, Philip, Gitler, Aaron D., Robberecht, Wim, Van Den Bosch, Ludo

“…Hexanucleotide repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) (c9ALS/FTD)…”
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Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity by Bogaert, Elke, Boeynaems, Steven, Kato, Masato, Guo, Lin, Caulfield, Thomas R., Steyaert, Jolien, Scheveneels, Wendy, Wilmans, Nathalie, Haeck, Wanda, Hersmus, Nicole, Schymkowitz, Joost, Rousseau, Frederic, Shorter, James, Callaerts, Patrick, Robberecht, Wim, Van Damme, Philip, Van Den Bosch, Ludo

“…RNA-binding protein aggregation is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and…”
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A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore by Vanderhaeghe, Silke, Prerad, Jovan, Tharkeshwar, Arun Kumar, Goethals, Elien, Vints, Katlijn, Beckers, Jimmy, Scheveneels, Wendy, Debroux, Eveline, Princen, Katrien, Van Damme, Philip, Fivaz, Marc, Griffioen, Gerard, Van Den Bosch, Ludo

“…Valosin-containing protein (VCP) is a ubiquitously expressed type II AAA ATPase protein, implicated in both amyotrophic lateral sclerosis (ALS) and…”
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Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity by Van Damme, Philip, Bogaert, Elke, Dewil, Maarten, Hersmus, Nicole, Kiraly, Dora, Scheveneels, Wendy, Bockx, Ilse, Braeken, Dries, Verpoorten, Nathalie, Verhoeven, Kristien, Timmerman, Vincent, Herijgers, Paul, Callewaert, Geert, Carmeliet, Peter, Van Den Bosch, Ludo, Robberecht, Wim

“…Influx of Ca²⁺ ions through α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors contributes to neuronal damage in stroke, epilepsy, and…”
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Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration by Van Den Bosch, Ludo, Storkebaum, Erik, Vleminckx, Vicky, Moons, Lieve, Vanopdenbosch, Ludo, Scheveneels, Wendy, Carmeliet, Peter, Robberecht, Wim

“…Both in mice and humans, low expression levels of vascular endothelial growth factor (VEGF) are linked to adult-onset motor neuron disease or amyotrophic…”
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FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins by Steyaert, Jolien, Scheveneels, Wendy, Vanneste, Joni, Van Damme, Philip, Robberecht, Wim, Callaerts, Patrick, Bogaert, Elke, Van Den Bosch, Ludo

“…Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases characterized by the progressive loss of specific…”
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A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism by Swinnen, Bart, Bento-Abreu, Andre, Gendron, Tania F., Boeynaems, Steven, Bogaert, Elke, Nuyts, Rik, Timmers, Mieke, Scheveneels, Wendy, Hersmus, Nicole, Wang, Jiou, Mizielinska, Sarah, Isaacs, Adrian M., Petrucelli, Leonard, Lemmens, Robin, Van Damme, Philip, Van Den Bosch, Ludo, Robberecht, Wim

“…The exact mechanism underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with the GGGGCC repeat expansion in C9orf72 is…”
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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport by Tziortzouda, Paraskevi, Steyaert, Jolien, Scheveneels, Wendy, Sicart, Adria, Stoklund Dittlau, Katarina, Barbosa Correia, Adriana Margarida, Burg, Thibaut, Pal, Arun, Hermann, Andreas, Van Damme, Philip, Moens, Thomas G., Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently lacks effective treatments. Mutations in the RNA-binding protein FUS…”
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The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding by De Muynck, Louis, Herdewyn, Sarah, Beel, Sander, Scheveneels, Wendy, Van Den Bosch, Ludo, Robberecht, Wim, Van Damme, Philip

“…Abstract Progranulin (PGRN) is a growth factor involved in wound healing, inflammation, tumor growth, and neurodegeneration. Mutations in the gene encoding…”
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VEGF protects motor neurons against excitotoxicity by upregulation of GluR2 by Bogaert, Elke, Van Damme, Philip, Poesen, Koen, Dhondt, Joke, Hersmus, Nicole, Kiraly, Dora, Scheveneels, Wendy, Robberecht, Wim, Van Den Bosch, Ludo

“…Abstract Influx of Ca2+ ions through the α-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptors is toxic to neurons and contributes to motor…”
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Genetic ablation of IP 3 receptor 2 increases cytokines and decreases survival of SOD1 G93A mice by Staats, Kim A., Humblet-Baron, Stephanie, Bento-Abreu, Andre, Scheveneels, Wendy, Nikolaou, Alexandros, Deckers, Kato, Lemmens, Robin, Goris, An, Van Ginderachter, Jo A., Van Damme, Philip, Hisatsune, Chihiro, Mikoshiba, Katsuhiko, Liston, Adrian, Robberecht, Wim, Van Den Bosch, Ludo

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Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice by Staats, Kim A, Humblet-Baron, Stephanie, Bento-Abreu, Andre, Scheveneels, Wendy, Nikolaou, Alexandros, Deckers, Kato, Lemmens, Robin, Goris, An, Van Ginderachter, Jo A, Van Damme, Philip, Hisatsune, Chihiro, Mikoshiba, Katsuhiko, Liston, Adrian, Robberecht, Wim, Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease characterized by the selective death of motor neurons. Disease…”
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