Search Results - "Scherphof, G L"

A potential role of macrophage activation in the treatment of cancer by Klimp, A.H., de Vries, E.G.E., Scherphof, G.L., Daemen, T.

“…One of the functions of macrophages is to provide a defense mechanism against tumor cells. In the last decades the mechanism of tumor cell killing by…”
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The role of hepatocytes in the clearance of liposomes from the blood circulation by Scherphof, Gerrit L, Kamps, Jan A.A.M

“…In this chapter we summarize literature and describe in more detail our own observations over a period of nearly two decennia on the role of hepatocytes in the…”
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Uptake of phosphatidylserine-containing liposomes by liver sinusoidal endothelial cells in the serum-free perfused rat liver by Rothkopf, C., Fahr, A., Fricker, G., Scherphof, G.L., Kamps, J.A.A.M.

“…We studied the kinetics of hepatic uptake of liposomes during serum-free recirculating perfusion of rat livers. Liposomes consisted of phosphatidylcholine,…”
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Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells by KONING, G. A, GORTER, A, SCHERPHOF, G. L, KAMPS, J. A. A. M

“…We have investigated the antiproliferative action towards CC531 colon adenocarcinoma cells of target cell-specific immunoliposomes containing the amphiphilic…”
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A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells by Yan, X., Poelstra, K., Scherphof, G.L., Kamps, J.A.A.M.

“…We investigated the potential role of scavenger receptor B-I (SR-BI) in the selective removal of liposomal markers from blood by hepatocytes. Liposomes were…”
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Different intrahepatic distribution of phosphatidylglycerol and phosphatidylserine liposomes in the rat by Daemen, T, Velinova, M, Regts, J, de Jager, M, Kalicharan, R, Donga, J, van der Want, J J L, Scherphof, G L

“…Liposomes with diameters of 200 to 400 nm containing phosphatidylserine (PS) or phosphatidylglycerol (PG) were injected intravenously into rats. Two hours…”
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Activation of peritoneal cells upon in vivo transfection with a recombinant alphavirus expressing GM-CSF by KLIMP, A. H, VAN DER VAART, E, LANSINK, P. O, WITHOFF, S, DE VRIES, E. G. E, SCHERPHOF, G. L, WILSCHUT, J, DAEMEN, T

“…In this study we determined the in vivo localization of recombinant proteins expressed by intraperitoneally (i.p.) injected recombinant Semliki Forest virus…”
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Effect of intraperitoneally administered recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) on the cytotoxic potential of murine peritoneal cells by KLIMP, A. H, REGTS, J, SCHERPHOF, G. L, DE VRIES, E. G. E, DAEMEN, T

“…We studied the effect of recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) on the cytotoxic potential of murine peritoneal cells…”
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Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes by Dams, E T, Laverman, P, Oyen, W J, Storm, G, Scherphof, G L, van Der Meer, J W, Corstens, F H, Boerman, O C

“…Sterically stabilized liposomes are considered promising carriers of therapeutic agents because they can facilitate controlled release of the drugs, thereby…”
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Uptake of Long-Circulating Immunoliposomes, Directed Against Colon Adenocarcinoma Cells, by Liver Metastases of Colon Cancer by Kamps, Jan, Koning, Gerben, Velinova, Maria, Morselt, Henriëtte, Wilkens, Marga, Gorter, Arko, Donga, Jan, Scherphof, Gerrit

“…AbstractRadiolabeled ([3H]cholesteryloleyl ether) immunoliposomes directed against rat colon adenocarcinoma CC531 cells were prepared by random coupling of a…”
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The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse by Yan, Xuedong, Kuipers, Folkert, Havekes, Louis M., Havinga, Rick, Dontje, Bert, Poelstra, Klaas, Scherphof, Gerrit L., Kamps, Jan A.A.M.

“…We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively…”
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Tumoricidal response of liver macrophages isolated from rats bearing liver metastases of colon adenocarcinoma by Thomas, C, Nijenhuis, A M, Dontje, B, Daemen, T, Scherphof, G L

“…Intraportal inoculation of CC531 adenocarcinoma cells into syngeneic rats causes an increase of liver macrophage cell number but not of major…”
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Uptake and processing of immunoglobulin-coated liposomes by subpopulations of rat liver macrophages by Derksen, J T, Morselt, H W, Scherphof, G L

“…In vivo uptake and processing by liver macrophages (Kupffer cells) of liposomes, covalently coated with rabbit immunoglobulin (Ig liposomes) was studied…”
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Dietary fish oil potentiates bile acid-induced cholesterol secretion into bile in rats by Smit, M J, Verkade, H J, Havinga, R, Vonk, R J, Scherphof, G L, In 't Veld, G, Kuipers, F

“…Recently we demonstrated that dietary fish oil (FO) causes changes in intrahepatic cholesterol transport and hypersecretion of cholesterol into bile in rats…”
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Liposomes: vehicles for the targeted and controlled delivery of peptides and proteins by Crommelin, D.J.A, Daemen, T, Scherphof, G.L, Vingerhoeds, M.H, Heeremans, J.L.M, Kluft, C, Storm, G

“…Several approaches are presented that have been developed for the liposomal delivery of peptides and proteins. For a rational design of targeted liposomes, the…”
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UPTAKE AND INTRACELLULAR PROCESSING OF PEG-LIPOSOMES AND PEG-IMMUNOLIPOSOMES BY KUPFFER CELLS IN VITRO by Koning, Gerben A., Morselt, Henriëtte W. M., Kamps, Jan A. A. M., Scherphof, Gerrit L.

“…Specific targeting of drugs to for instance tumors or sites of inflammation may be achieved by means of immunoliposomes carrying site-specific antibodies on…”
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In vivo Stability of Ester- and Ether-Linked Phospholipid-Containing Liposomes as Measured by Perturbed Angular Correlation Spectroscopy by Derksen, Johannes T., Baldeschwieler, John D., Scherphof, Gerrit L.

“…To evaluate liposome formulations for use as intracellular sustained-release drug depots, we have compared the uptake and degradation in rat liver and spleen…”
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Liposome Elimination by Non-Phagocytic Cells of the Liver by Scherphof, Gerrit L., Daemen, Toos, Romero, Eder L., Kamps, Jan A.A.M.

“…Abstract In this contribution we summarize our observations over a period of nearly two decennia on the role of hepatocytes in the hepatic clearance of…”
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Interaction of liposomes with Kupffer cells in vitro by Dijkstra, J, van Galen, W J, Hulstaert, C E, Kalicharan, D, Roerdink, F H, Scherphof, G L

“…We investigated the interaction of liposomes with rat Kupffer cells in monolayer maintenance culture. The liposomes (large unilamellar vesicles, LUV) were…”
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Processing of the phospholipid analogue phosphatidyl(N-sulphorhodamine B sulphonyl)ethanolamine by rat hepatocytes in vitro and in vivo by VERKADE, H. J, ZAAL, K. J. M, DERKSEN, J. T. P, VONK, R. J, HOEKSTRA, D, KUIPERS, F, SCHERPHOF, G. L

“…We have investigated the processing of the non-exchangeable fluorescent phospholipid analogue phosphatidyl(N-sulphorhodamine B sulphonyl)ethanolamine (N-Rh-PE)…”
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