Search Results - "Scherphof, G"

A potential role of macrophage activation in the treatment of cancer by Klimp, A.H., de Vries, E.G.E., Scherphof, G.L., Daemen, T.

“…One of the functions of macrophages is to provide a defense mechanism against tumor cells. In the last decades the mechanism of tumor cell killing by…”
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The role of hepatocytes in the clearance of liposomes from the blood circulation by Scherphof, Gerrit L, Kamps, Jan A.A.M

“…In this chapter we summarize literature and describe in more detail our own observations over a period of nearly two decennia on the role of hepatocytes in the…”
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Uptake of phosphatidylserine-containing liposomes by liver sinusoidal endothelial cells in the serum-free perfused rat liver by Rothkopf, C., Fahr, A., Fricker, G., Scherphof, G.L., Kamps, J.A.A.M.

“…We studied the kinetics of hepatic uptake of liposomes during serum-free recirculating perfusion of rat livers. Liposomes consisted of phosphatidylcholine,…”
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Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes by Dams, E T, Laverman, P, Oyen, W J, Storm, G, Scherphof, G L, van Der Meer, J W, Corstens, F H, Boerman, O C

“…Sterically stabilized liposomes are considered promising carriers of therapeutic agents because they can facilitate controlled release of the drugs, thereby…”
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The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse by Yan, Xuedong, Kuipers, Folkert, Havekes, Louis M., Havinga, Rick, Dontje, Bert, Poelstra, Klaas, Scherphof, Gerrit L., Kamps, Jan A.A.M.

“…We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively…”
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A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells by Yan, X., Poelstra, K., Scherphof, G.L., Kamps, J.A.A.M.

“…We investigated the potential role of scavenger receptor B-I (SR-BI) in the selective removal of liposomal markers from blood by hepatocytes. Liposomes were…”
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Lymphatic uptake and biodistribution of liposomes after subcutaneous injection: IV. Fate of liposomes in regional lymph nodes by Oussoren, C, Velinova, M, Scherphof, G, van der Want, J.J, van Rooijen, N, Storm, G

“…The ability of clodronate-containing liposomes to deplete lymph nodes of macrophages was used as a tool to investigate the fate of liposomes in regional lymph…”
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Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells by KONING, G. A, GORTER, A, SCHERPHOF, G. L, KAMPS, J. A. A. M

“…We have investigated the antiproliferative action towards CC531 colon adenocarcinoma cells of target cell-specific immunoliposomes containing the amphiphilic…”
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Different intrahepatic distribution of phosphatidylglycerol and phosphatidylserine liposomes in the rat by Daemen, T, Velinova, M, Regts, J, de Jager, M, Kalicharan, R, Donga, J, van der Want, J J L, Scherphof, G L

“…Liposomes with diameters of 200 to 400 nm containing phosphatidylserine (PS) or phosphatidylglycerol (PG) were injected intravenously into rats. Two hours…”
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Activation of peritoneal cells upon in vivo transfection with a recombinant alphavirus expressing GM-CSF by KLIMP, A. H, VAN DER VAART, E, LANSINK, P. O, WITHOFF, S, DE VRIES, E. G. E, SCHERPHOF, G. L, WILSCHUT, J, DAEMEN, T

“…In this study we determined the in vivo localization of recombinant proteins expressed by intraperitoneally (i.p.) injected recombinant Semliki Forest virus…”
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Uptake of Long-Circulating Immunoliposomes, Directed Against Colon Adenocarcinoma Cells, by Liver Metastases of Colon Cancer by Kamps, Jan, Koning, Gerben, Velinova, Maria, Morselt, Henriëtte, Wilkens, Marga, Gorter, Arko, Donga, Jan, Scherphof, Gerrit

“…AbstractRadiolabeled ([3H]cholesteryloleyl ether) immunoliposomes directed against rat colon adenocarcinoma CC531 cells were prepared by random coupling of a…”
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Effect of intraperitoneally administered recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) on the cytotoxic potential of murine peritoneal cells by KLIMP, A. H, REGTS, J, SCHERPHOF, G. L, DE VRIES, E. G. E, DAEMEN, T

“…We studied the effect of recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) on the cytotoxic potential of murine peritoneal cells…”
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Active targeting with particulate carrier systems in the blood compartment by Crommelin, D.J.A., Scherphof, G., Storm, G.

“…This review deals with active targeting of particulate drug carriers through (1) physico-chemical (e.g., complex formation between a homing device and a…”
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Liposomes: vehicles for the targeted and controlled delivery of peptides and proteins by Crommelin, D.J.A, Daemen, T, Scherphof, G.L, Vingerhoeds, M.H, Heeremans, J.L.M, Kluft, C, Storm, G

“…Several approaches are presented that have been developed for the liposomal delivery of peptides and proteins. For a rational design of targeted liposomes, the…”
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Fusion activity of influenza virus. A comparison between biological and artificial target membrane vesicles by Stegmann, T, Hoekstra, D, Scherphof, G, Wilschut, J

“…We have investigated the pH-dependent fusion activity of influenza virus toward human erythrocyte ghosts, utilizing a recently developed fluorescence assay,…”
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On the mechanism of hepatic transendothelial passage of large liposomes by Romero, Eder L., Morilla, Maria-José, Regts, Joke, Koning, Gerben A., Scherphof, Gerrit L.

“…Liposomes of 400 nm in diameter can cross the 100-nm fenestrations in the endothelium of the hepatic sinusoid, provided they contain phosphatidylserine (PS)…”
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Massive Targeting of Liposomes, Surface-Modified with Anionized Albumins, to Hepatic Endothelial Cells by Jan A. A. M. Kamps, Henriette W. M. Morselt, Swart, Pieter J., Dick K. F. Meijer, Scherphof, Gerrit L.

“…Human serum albumin (HSA) derivatized with cis-aconitic anhydride was covalently coupled to liposomes with a size of approximately 100 nm [polyaconitylated HSA…”
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Selective transfer of a lipophilic prodrug of 5-fluorodeoxyuridine from immunoliposomes to colon cancer cells by Koning, Gerben A., Morselt, Henriëtte W.M., Velinova, Maria J., Donga, Jan, Gorter, Arko, Allen, Theresa M., Zalipsky, Samuel, Kamps, Jan A.A.M., Scherphof, Gerrit L.

“…A monoclonal antibody against the rat colon carcinoma CC531 was covalently coupled to liposomes containing a dipalmitoylated derivative of the anticancer drug…”
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Uptake and processing of immunoglobulin-coated liposomes by subpopulations of rat liver macrophages by Derksen, J T, Morselt, H W, Scherphof, G L

“…In vivo uptake and processing by liver macrophages (Kupffer cells) of liposomes, covalently coated with rabbit immunoglobulin (Ig liposomes) was studied…”
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Uptake of liposomes containing phosphatidylserine by liver cells in vivo and by sinusoidal liver cells in primary culture: in vivo-in vitro differences by Kamps, J A, Morselt, H W, Scherphof, G L

“…The interaction with liver cells of liposomes containing different mol fractions of phosphatidylserine was investigated in vivo and in vitro. Increasing the…”
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