Search Results - "Schernthaner, G.‐H."

Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site by Hadzijusufovic, E, Albrecht-Schgoer, K, Huber, K, Hoermann, G, Grebien, F, Eisenwort, G, Schgoer, W, Herndlhofer, S, Kaun, C, Theurl, M, Sperr, W R, Rix, U, Sadovnik, I, Jilma, B, Schernthaner, G H, Wojta, J, Wolf, D, Superti-Furga, G, Kirchmair, R, Valent, P

“…The BCR/ABL1 inhibitor Nilotinib is increasingly used to treat patients with chronic myeloid leukemia (CML). Although otherwise well-tolerated, Nilotinib has…”
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Expression of the target receptor CD33 in CD34+/CD38−/CD123+ AML stem cells by Hauswirth, A.W., Florian, S., Printz, D., Sotlar, K., Krauth, M.-T., Fritsch, G., Schernthaner, G.-H., Wacheck, V., Selzer, E., Sperr, W.R., Valent, P.

“…Background  CD33 (Siglec‐3) is becoming increasingly important as a target of antibody‐mediated therapy in acute myeloid leukaemia (AML). In normal…”
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Thrombin generation in morbid obesity: significant reduction after weight loss by AY, L., KOPP, H.‐P., BRIX, J.‐M., AY, C., QUEHENBERGER, P., SCHERNTHANER, G.‐H., PABINGER, I., SCHERNTHANER, G.

“…Background: Patients with morbid obesity (MO; body mass index > 40 kg m−2) suffer from an increased risk of cardiovascular disease, stroke, venous…”
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Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess by Poredoš, P, Schernthaner, G H, Blinc, A, Mikhailidis, D P, Jensterle, M, Anagnostis, P, Antignani, P L, Studen, K Bajuk, Šabović, M, Ježovnik, M K

“…Cushing syndrome (CS), characterised by endogenous or exogenous glucocorticoid hormone excess, is associated with several systemic complications, including…”
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Glucose-lowering therapy in type 2 diabetes: New hope after the EMPA-REG outcome trial by Schernthaner, G., Schernthaner, G.-H.

“…Prevention of cardiovascular morbidity and mortality remains the key factor in the treatment of type 2 diabetes (T2DM). In the early phase of T2DM,…”
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The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity by Brix, J M, Höllerl, F, Kopp, H-P, Schernthaner, G H, Schernthaner, G

“…Objective: The increased cardiovascular (CV) disease risk in patients with morbid obesity (MO) cannot be fully explained by traditional CV risk factors…”
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Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes by Krzyzanowska, K, Zemany, L, Krugluger, W, Schernthaner, G. H, Mittermayer, F, Schnack, C, Rahman, R, Brix, J, Kahn, B. B, Schernthaner, G

“…Aims/hypothesis Pregnancy is characterised by temporarily increased insulin resistance. Gestational diabetes occurs when pancreatic beta cell function is…”
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Variable expression of activation-linked surface antigens on human mast cells in health and disease by Valent, P., Schernthaner, G.-H., Sperr, W. R., Fritsch, G., Agis, H., Willheim, M., Bühring, H.-J., Orfao, A., Escribano, L.

“…Mast cells (MC) are multipotent effector cells of the immune system. They contain an array of biologically active mediator substances in their granules. MC…”
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Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus by Schlager, O., Hammer, A., Willfort-Ehringer, A., Fritsch, M., Rami-Merhar, B., Schober, E., Nagl, K., Giurgea, A., Margeta, C., Zehetmayer, S., Schernthaner, G. H., Koppensteiner, R., Gschwandtner, M. E.

“…Aims/hypothesis Deterioration of microvascular function may have an early onset in individuals with type 1 diabetes mellitus. We hypothesised that…”
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Detection of differentiation‐ and activation‐linked cell surface antigens on cultured mast cell progenitors by Schernthaner, G.‐H., Hauswirth, A. W., Baghestanian, M., Agis, H., Ghannadan, M., Worda, C., Krauth, M.‐T., Printz, D., Fritsch, G., Sperr, W. R., Valent, P.

“…Background:  Mast cells (MC) are multifunctional effector cells of the immune system. They derive from uncommitted CD34+ hemopoietic progenitor cells (HPC)…”
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Soluble CD40L in patients with morbid obesity: significant reduction after bariatric surgery by Schernthaner, G.-H., Kopp, H.-P., Krzyzanowska, K., Kriwanek, S., Koppensteiner, R., Schernthaner, G.

“…Background  Morbid obesity is associated with increased cardiovascular morbidity and mortality. Recent studies suggest that soluble CD40 Ligand (sCD40L) may…”
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Chronic complications of venous thromboembolism by Winter, M.‐P., Schernthaner, G. H., Lang, I. M.

“…Summary Venous thromboembolism (VTE) is a common disease (~700 per 100 000) that is associated with significant risk of recurrence, chronic complications, and…”
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No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease by Schernthaner, G.-H., Plank, C., Minar, E., Bieglmayer, C., Koppensteiner, R., Schernthaner, G.

“…Background  Although peripheral arterial occlusive disease (PAOD) is significantly associated with elevated homocysteine levels, the clinical relevance of…”
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CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross-linking by Hauswirth, A W, Escribano, L, Prados, A, Nuñez, R, Mirkina, I, Kneidinger, M, Florian, S, Sonneck, K, Vales, A, Schernthaner, G-H, Sanchez-Muñoz, L, Sperr, W R, Bühring, H-J, Orfao, A, Valent, P

“…The ectoenzyme E-NPP3 (CD203c) has recently been identified as a novel activation-linked cell surface antigen on basophils. In the present study, we examined…”
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Effects of various statins on cytokine‐dependent growth and IgE‐dependent release of histamine in human mast cells by Krauth, M. T., Majlesi, Y., Sonneck, K., Samorapoompichit, P., Ghannadan, M., Hauswirth, A. W., Baghestanian, M., Schernthaner, G. H., Worda, C., Müller, M. R., Sperr, W. R., Valent, P.

“…Background:  Statins are inhibitors of hydroxymethylglutaryl coenzyme A (HMG CoA) reductase, a key enzyme in mevalonic acid (MVA)‐dependent signaling. Recent…”
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Interleukin-3 promotes the expression of E-NPP3/CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy by Hauswirth, A W, Sonneck, K, Florian, S, Krauth, M T, Bohm, A, Sperr, W R, Valenta, R, Schernthaner, G H, Printz, D, Fritsch, G, Buhring, H J, Valent, P

“…We recently identified the ectoenzyme CD203c as a novel basophil activation antigen that is upregulated in response to FcepsilonRI cross-linkage. We…”
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Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis by Sperr, Wolfgang R, Escribano, Luis, Jordan, John-Hendrik, Schernthaner, Gerit-Holger, Kundi, Michael, Horny, Hans-Peter, Valent, Peter

“…In the present study, cytological properties of bone marrow mast cells (MC) were analyzed and correlated with clinical parameters in 69 patients with systemic…”
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Evaluation of neoplastic human mast cells by tryptase-immunoelectron microscopy by Samorapoompichit, P, Schernthaner, G-H, Worda, C, Wimazal, F, Krauth, M-T, Sperr, W R, Valent, P

“…Aims : To analyse and characterize the ultrastructural morphology of normal tissue mast cells (MC) and neoplastic bone marrow MC. Methods : We have examined…”
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Utility of flow cytometric analysis of mast cells in the diagnosis and classification of adult mastocytosis by Escribano, Luis, Dı́az-Agustı́n, Beatriz, Bellas, Carmen, Navalón, Raquel, Nuñez, Rosa, Sperr, Wolfgang R, Schernthaner, Gerit-Holger, Valent, Peter, Orfao, Alberto

“…The diagnosis of bone marrow (BM) involvement in mastocytosis has mainly been based on conventional histology. Nevertheless, in recent years, three major…”
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Secreted Frizzled-Related Protein 4 (SFRP4) is Elevated in Patients with Diabetes Mellitus by Brix, J M, Krzizek, E C, Hoebaus, C, Ludvik, B, Schernthaner, G, Schernthaner, G H

“…Recently, SFRP4 was identified as a molecular link between islet inflammation and defective insulin secretion. Gene co-expression analysis detected a molecule…”
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