Search Results - "Schermerhorn, Kelly M"

Pre-steady-state Kinetic Analysis of a Family D DNA Polymerase from Thermococcus sp. 9°N Reveals Mechanisms for Archaeal Genomic Replication and Maintenance by Schermerhorn, Kelly M., Gardner, Andrew F.

“…Family D DNA polymerases (polDs) have been implicated as the major replicative polymerase in archaea, excluding the Crenarchaeota branch, and bear little…”
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A Chemical and Kinetic Perspective on Base Excision Repair of DNA by Schermerhorn, Kelly M, Delaney, Sarah

“…Our cellular genome is continuously exposed to a wide spectrum of exogenous and endogenous DNA damaging agents. These agents can lead to formation of an…”
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Transient-State Kinetics of Apurinic/Apyrimidinic (AP) Endonuclease 1 Acting on an Authentic AP Site and Commonly Used Substrate Analogs: The Effect of Diverse Metal Ions and Base Mismatches by Schermerhorn, Kelly M, Delaney, Sarah

“…Apurinic/apyrimidinic endonuclease 1 (APE1) is an Mg2+-dependent enzyme responsible for incising the DNA backbone 5′ to an apurinic/apyrimidinic (AP) site…”
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Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymes by Greenough, Lucia, Schermerhorn, Kelly M, Mazzola, Laurie, Bybee, Joanna, Rivizzigno, Danielle, Cantin, Elizabeth, Slatko, Barton E, Gardner, Andrew F

“…Detailed biochemical characterization of nucleic acid enzymes is fundamental to understanding nucleic acid metabolism, genome replication and repair. We report…”
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High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases by Schermerhorn, Kelly M, Tanner, Nathan, Kelman, Zvi, Gardner, Andrew F

“…The minichromosome maintenance (MCM) complex is the replicative helicase responsible for unwinding DNA during archaeal and eukaryal genome replication. To…”
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Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion by Jarem, Daniel A., Wilson, Nicole R., Schermerhorn, Kelly M., Delaney, Sarah

“…• OGG1 has been implicated in trinucleotide repeat expansion. • The activity of OGG1 is not influenced by DNA sequence context. • DNA structure does modulate…”
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Complete Genome Sequence of Kluyveromyces lactis Strain GG799, a Common Yeast Host for Heterologous Protein Expression by Chuzel, Léa, Ganatra, Mehul B, Schermerhorn, Kelly M, Gardner, Andrew F, Anton, Brian P, Taron, Christopher H

“…We report the genome sequence of the dairy yeast strain GG799 obtained using the Pacific Biosciences RS II platform. strain GG799 is a common host for the…”
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Pre-steady-state Kinetic Analysis of a Family D DNA Polymerase from Thermococcus sp. 9 degree N Reveals Mechanisms for Archaeal Genomic Replication and Maintenance by Schermerhorn, Kelly M, Gardner, Andrew F

“…Background: Family D DNA polymerase (polD) is important for replication in most archaea, excluding Crenarchaeota. Results: We report a detailed kinetic…”
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122 Kinetics of apurinic/apyrimidinic endonuclease 1 (APE1) on an authentic AP site or an AP site analog by Schermerhorn, Kelly M., Delaney, Sarah

“…Our genomic DNA is endlessly exposed to a wide variety of exogenous and endogenous DNA-damaging agents. One of the most abundant DNA lesions is an…”
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