Search Results - "Scherf, Kristian"

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice by Kölling, Malte, Kaucsar, Tamas, Schauerte, Celina, Hübner, Anika, Dettling, Angela, Park, Joon-Keun, Busch, Martin, Wulff, Xaver, Meier, Matthias, Scherf, Kristian, Bukosza, Nóra, Szénási, Gábor, Godó, Mária, Sharma, Amit, Heuser, Michael, Hamar, Peter, Bang, Claudia, Haller, Hermann, Thum, Thomas, Lorenzen, Johan M.

“…Diabetic nephropathy is the main cause of end-stage renal disease. MicroRNAs are powerful regulators of the genome, and global expression profiling revealed…”
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MicroRNA-24 antagonism prevents renal ischemia reperfusion injury by Lorenzen, Johan M, Kaucsar, Tamas, Schauerte, Celina, Schmitt, Roland, Rong, Song, Hübner, Anika, Scherf, Kristian, Fiedler, Jan, Martino, Filippo, Kumarswamy, Regalla, Kölling, Malte, Sörensen, Inga, Hinz, Hebke, Heineke, Joerg, van Rooij, Eva, Haller, Hermann, Thum, Thomas

“…Ischemia-reperfusion (I/R) injury of the kidney is a major cause of AKI. MicroRNAs (miRs) are powerful regulators of various diseases. We investigated the role…”
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Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis by Lorenzen, Johan M, Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K, Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A, Weidemann, Frank, Müller, Oliver J, Haller, Hermann, Thum, Thomas

“…Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are…”
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Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis by Kenneweg, Franziska, Bang, Claudia, Xiao, Ke, Boulanger, Chantal M., Loyer, Xavier, Mazlan, Stephane, Schroen, Blanche, Hermans-Beijnsberger, Steffie, Foinquinos, Ariana, Hirt, Marc N., Eschenhagen, Thomas, Funcke, Sandra, Stojanovic, Stevan, Genschel, Celina, Schimmel, Katharina, Just, Annette, Pfanne, Angelika, Scherf, Kristian, Dehmel, Susann, Raemon-Buettner, Stella M., Fiedler, Jan, Thum, Thomas

“…Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular diseases, but detailed information about the intercellular lncRNA…”
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Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction by Schauerte, Celina, Hübner, Anika, Rong, Song, Wang, Shijun, Shushakova, Nelli, Mengel, Michael, Dettling, Angela, Bang, Claudia, Scherf, Kristian, Koelling, Malte, Melk, Anette, Haller, Hermann, Thum, Thomas, Lorenzen, Johan M

“…Chronic renal allograft dysfunction (CAD) is a major limiting factor of long-term graft survival. It is characterized by interstitial fibrosis and tubular…”
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Circulating cardiovascular microRNAs in critically ill COVID‐19 patients by Garg, Ankita, Seeliger, Benjamin, Derda, Anselm A., Xiao, Ke, Gietz, Anika, Scherf, Kristian, Sonnenschein, Kristina, Pink, Isabell, Hoeper, Marius M., Welte, Tobias, Bauersachs, Johann, David, Sascha, Bär, Christian, Thum, Thomas

“…Aims Coronavirus disease 2019 (COVID‐19) is a still growing pandemic, causing many deaths and socio‐economic damage. Elevated expression of the severe acute…”
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Long noncoding RNA Chast promotes cardiac remodeling by Viereck, Janika, Kumarswamy, Regalla, Foinquinos, Ariana, Xiao, Ke, Avramopoulos, Petros, Kunz, Meik, Dittrich, Marcus, Maetzig, Tobias, Zimmer, Karina, Remke, Janet, Just, Annette, Fendrich, Jasmin, Scherf, Kristian, Bolesani, Emiliano, Schambach, Axel, Weidemann, Frank, Zweigerdt, Robert, de Windt, Leon J, Engelhardt, Stefan, Dandekar, Thomas, Batkai, Sandor, Thum, Thomas

“…Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in cardiac development. However, understanding of lncRNAs in cardiac…”
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Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction by Schimmel, Katharina, Jung, Mira, Foinquinos, Ariana, José, Gorka San, Beaumont, Javier, Bock, Katharina, Grote-Levi, Lea, Xiao, Ke, Bär, Christian, Pfanne, Angelika, Just, Annette, Zimmer, Karina, Ngoy, Soeun, López, Begoña, Ravassa, Susana, Samolovac, Sabine, Janssen-Peters, Heike, Remke, Janet, Scherf, Kristian, Dangwal, Seema, Piccoli, Maria-Teresa, Kleemiss, Felix, Kreutzer, Fabian Philipp, Kenneweg, Franziska, Leonardy, Julia, Hobuß, Lisa, Santer, Laura, Do, Quoc-Tuan, Geffers, Robert, Braesen, Jan Hinrich, Schmitz, Jessica, Brandenberger, Christina, Müller, Dominik N., Wilck, Nicola, Kaever, Volkhard, Bähre, Heike, Batkai, Sandor, Fiedler, Jan, Alexander, Kevin M., Wertheim, Bradley M., Fisch, Sudeshna, Liao, Ronglih, Diez, Javier, González, Arantxa, Thum, Thomas

“…BACKGROUND:Myocardial fibrosis is a hallmark of cardiac remodeling and functionally involved in heart failure development, a leading cause of deaths worldwide…”
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Elevated levels of miR-181c and miR-633 in the CSF of patients with MS: A validation study by Kramer, Svenja, Haghikia, Arash, Bang, Claudia, Scherf, Kristian, Pfanne, Angelika, Duscha, Alexander, Kaisler, Johannes, Gisevius, Barbara, Gold, Ralf, Thum, Thomas, Haghikia, Aiden

“…OBJECTIVETo validate a previously discovered microRNA (miRNA) panel in the CSF of patients with MS, we now tested the diagnostic value of CSF-derived candidate…”
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