Search Results - "Scherer, Thomas M."

Role of Cosolute–Protein Interactions in the Dissociation of Monoclonal Antibody Clusters by Scherer, Thomas M

“…The solution thermodynamics and interactions of a reversibly self-associating monoclonal IgG1 antibody (mAb1) have been investigated as a function of cosolute…”
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Small-Angle Neutron Scattering Characterization of Monoclonal Antibody Conformations and Interactions at High Concentrations by Yearley, Eric J., Zarraga, Isidro E., Shire, Steven J., Scherer, Thomas M., Gokarn, Yatin, Wagner, Norman J., Liu, Yun

“…Small-angle neutron scattering (SANS) is used to probe the solution structure of two protein therapeutics (monoclonal antibodies 1 and 2 (MAb1 and MAb2)) and…”
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Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations by Lilyestrom, Wayne G., Yadav, Sandeep, Shire, Steven J., Scherer, Thomas M.

“…The rheological properties of macromolecular and colloidal suspensions are dependent on the thermodynamic and kinetic parameters that define viscous flow, and…”
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Intermolecular Interactions of IgG1 Monoclonal Antibodies at High Concentrations Characterized by Light Scattering by Scherer, Thomas M, Liu, Jun, Shire, Steven J, Minton, Allen P

“…Light scattering intensity measurements of solutions of two purified monoclonal antibodies were performed over a wide range of concentrations (0.5−275 mg/mL)…”
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Cosolute Effects on the Chemical Potential and Interactions of an IgG1 Monoclonal Antibody at High Concentrations by Scherer, Thomas M

“…The solution thermodynamics and interactions of a reversibly self-associating IgG1 monoclonal antibody have been investigated as a function of cosolute type…”
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Cluster Size and Quinary Structure Determine the Rheological Effects of Antibody Self-Association at High Concentrations by Wang, Wenhua, Lilyestrom, Wayne G, Hu, Zhi Yu, Scherer, Thomas M

“…The question of how nonspecific reversible intermolecular protein interactions affect solution rheology at high concentrations is fundamentally rooted in the…”
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Influence of the Cosolute Environment on IgG Solution Structure Analyzed by Small-Angle X‑ray Scattering by Lilyestrom, Wayne G, Shire, Steven J, Scherer, Thomas M

“…Small-angle X-ray scattering experiments of two monoclonal antibodies (mAbs) were performed as a function of Hofmeister salt type and concentration including…”
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Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime by Yadav, Sandeep, Scherer, Thomas M., Shire, Steven J., Kalonia, Devendra S.

“…The present work discusses an alternative procedure to obtain static light scattering (SLS) parameters in a dilute and semidilute concentration regime from a…”
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Analysis of Multiple Redox Sites in Complexes [M(C5Me5)(Q)(NO)]n, M=Ru or Os, Q=o‐Quinones by Scherer, Thomas M., Hartenbach, Ingo, Lissner, Falk, Schwederski, Brigitte, Hübner, Ralph, Fiedler, Jan, Záliš, Stanislav, Sarkar, Biprajit, Kaim, Wolfgang

“…Neutral complexes [MII(C5Me5)(Q2−)(NO+)] with M=Ru or Os and the catecholates Q2− with 3,5‐di‐tert‐butyl (dtbc) or 3,4,5,6‐tetrachloro substituents (tcc) were…”
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Issues and Challenges of Subvisible and Submicron Particulate Analysis in Protein Solutions by Scherer, Thomas M., Leung, Stephenie, Owyang, Laura, Shire, Steven J.

“…The analysis of particulates has been a longstanding challenge in biopharmaceutical drug product development and quality control because the active…”
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Enzymatic hydrolysis of oligomeric models of poly-3-hydroxybutyrate by Scherer, T M, Fuller, R C, Goodwin, S, Lenz, R W

“…The mechanism of the enzymatic degradation of poly([R]-3-hydroxybutyrate) (PHB) was investigated by using well-defined model substrates, including both linear…”
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Assessment and significance of protein–protein interactions during development of protein biopharmaceuticals by Yadav, Sandeep, Liu, Jun, Scherer, Thomas M., Gokarn, Yatin, Demeule, Barthélemy, Kanai, Sonoko, Andya, James D., Shire, Steven J.

“…Early development of protein biotherapeutics using recombinant DNA technology involved progress in the areas of cloning, screening, expression and…”
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Production, Purification and Activity of an Extracellular Depolymerase from Aspergillus fumigatus by Scherer, Thomas M, Fuller, R Clinton, Lenz, Robert W, Goodwin, Steve

“…A strain of Aspergillus fumigatus, which was observed to rapidly degrade poly-3-hydroxybutyrate (PHB) in a leaf compost, was found to secrete an extracellular…”
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Hydrolase activity of an extracellular depolymerase from Aspergillus fumigatus with bacterial and synthetic polyesters by Scherer, Thomas M, Fuller, R.Clinton, Lenz, Robert W, Goodwin, Steve

“…An extracellular depolymerase produced by the fungus Aspergillus fumigatus was found to have hydrolytic activity towards both bacterial and synthetic…”
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Brain Insulin and Leptin Signaling in Metabolic Control by Scherer, Thomas, MD, Lehnert, Hendrik, MD, Hallschmid, Manfred, PhD

“…Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system…”
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Preparation, properties and biodegradation of stereoregular copolymers of (R,S-3-butyrolactone and 4-butyrolactone by Wu, Bin, Lenz, Robert W., Scherer, Thomas M.

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Preparation, properties and biodegradation of stereoregular copolymers of (R,S)-3-butyrolactone and 4-butyrolactone by Wu, Bin, Lenz, Robert W., Scherer, Thomas M.

“…Copolymers obtained from the copolymerization of (R,S)‐3‐butyrolactone ((R,S)‐3‐BL) and 4‐butyrolactone (4‐BL) catalyzed by isobutylaluminoxane were compared…”
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Preparation, properties and biodegradation of stereoregular copolymers of (R, S)-3-butyrolactone and 4-butyrolactone by BIN WU, LENZ, R. W, SCHERER, T. M

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