Search Results - "Scher, Jose"

The role of the gut microbiome in systemic inflammatory disease by Clemente, Jose C, Manasson, Julia, Scher, Jose U

“…ABSTRACTThe role of the gut microbiome in models of inflammatory and autoimmune disease is now well characterized. Renewed interest in the human microbiome and…”
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Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition by Scher, Jose U., Ogdie, Alexis, Merola, Joseph F., Ritchlin, Christopher

“…Psoriasis is one of the most common chronic inflammatory skin diseases, affecting 3% of the world’s population, and approximately one-third of patients with…”
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Covid-19 in Immune-Mediated Inflammatory Diseases — Case Series from New York by Haberman, Rebecca, Axelrad, Jordan, Chen, Alan, Castillo, Rochelle, Yan, Di, Izmirly, Peter, Neimann, Andrea, Adhikari, Samrachana, Hudesman, David, Scher, Jose U

“…The authors describe patients in New York City with known immune-mediated inflammatory disease in whom Covid-19 developed while they were receiving biologics,…”
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Key opinion leaders — a critical perspective by Scher, Jose U., Schett, Georg

“…Enormous progress has been made in the field of rheumatology in the past several decades, historically led by publicly funded academic innovators but in more…”
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Psoriatic arthritis from a mechanistic perspective by Schett, Georg, Rahman, Proton, Ritchlin, Christopher, McInnes, Iain B., Elewaut, Dirk, Scher, Jose U.

“…Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes (‘psoriatic disease’) that is defined by shared molecular pathogenesis…”
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The Microbiome in Psoriasis and Psoriatic Arthritis: Joints by Scher, Jose U

“…The microbiome is a known and established immunomodulator of many inflammatory disorders, including psoriasis and psoriatic arthritis. Microbes co-evolved with…”
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The microbiome and rheumatoid arthritis by Scher, Jose U, Abramson, Steven B

“…The microbes that inhabit our bodies play an important part in regulating the homeostasis of the immune system—disequilibrium in this symbiotic relationship…”
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Review: Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases by Scher, Jose U., Littman, Dan R., Abramson, Steven B.

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Basic Science Session 2. Recent Advances in Our Understanding of Psoriatic Arthritis Pathogenesis by Lubberts, Erik, Scher, Jose U, FitzGerald, Oliver

“…The second basic science session at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting focused on 2 recent…”
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Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity by Brusca, Samuel B, Abramson, Steven B, Scher, Jose U

“…PURPOSE OF REVIEWDespite the progress toward understanding the molecular pathogenesis of rheumatoid arthritis (RA), its cause remains elusive. Genes are…”
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The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions by Abdollahi-Roodsaz, Shahla, Abramson, Steven B., Scher, Jose U.

“…Key Points Emerging data implicate the human microbiome in the pathogenesis of inflammatory arthritides Mucosal sites exposed to high load of bacterial…”
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Short- and long-term effects of oral vancomycin on the human intestinal microbiota by Isaac, Sandrine, Scher, Jose U, Djukovic, Ana, Jiménez, Nuria, Littman, Dan R, Abramson, Steven B, Pamer, Eric G, Ubeda, Carles

“…Oral vancomycin remains the mainstay of therapy for severe infections produced by Clostridium difficile, the most prevalent cause of healthcare-associated…”
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Inflammasome Signaling and Impaired Vascular Health in Psoriasis by Garshick, Michael S, Barrett, Tessa J, Wechter, Todd, Azarchi, Sarah, Scher, Jose U, Neimann, Andrea, Katz, Stuart, Fuentes-Duculan, Judilyn, Cannizzaro, Maria V, Jelic, Sanja, Fisher, Edward A, Krueger, James G, Berger, Jeffrey S

“…OBJECTIVE—Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial…”
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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis by Scher, Jose U, Sczesnak, Andrew, Longman, Randy S, Segata, Nicola, Ubeda, Carles, Bielski, Craig, Rostron, Tim, Cerundolo, Vincenzo, Pamer, Eric G, Abramson, Steven B, Huttenhower, Curtis, Littman, Dan R

“…Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a…”
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Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation by Nayak, Renuka R., Alexander, Margaret, Deshpande, Ishani, Stapleton-Gray, Kye, Rimal, Bipin, Patterson, Andrew D., Ubeda, Carles, Scher, Jose U., Turnbaugh, Peter J.

“…Immunomodulatory drugs can inhibit bacterial growth, yet their mechanism of action, spectrum, and clinical relevance remain unknown. Methotrexate (MTX), a…”
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Distinct Polysaccharide Utilization Profiles of Human Intestinal Prevotella copri Isolates by Fehlner-Peach, Hannah, Magnabosco, Cara, Raghavan, Varsha, Scher, Jose U., Tett, Adrian, Cox, Laura M., Gottsegen, Claire, Watters, Aaron, Wiltshire-Gordon, John D., Segata, Nicola, Bonneau, Richard, Littman, Dan R.

“…Gut-dwelling Prevotella copri (P. copri), the most prevalent Prevotella species in the human gut, have been associated with diet and disease. However, our…”
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Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease by Scher, Jose U., Ubeda, Carles, Artacho, Alejandro, Attur, Mukundan, Isaac, Sandrine, Reddy, Soumya M., Marmon, Shoshana, Neimann, Andrea, Brusca, Samuel, Patel, Tejas, Manasson, Julia, Pamer, Eric G., Littman, Dan R., Abramson, Steven B.

“…Objective To characterize the diversity and taxonomic relative abundance of the gut microbiota in patients with never‐treated, recent‐onset psoriatic arthritis…”
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Not your average joint: Towards precision medicine in psoriatic arthritis by Castillo, Rochelle, Scher, Jose U.

“…Precision medicine, propelled by advances in multi-omics methods and analytics, aims to revolutionize patient care by using clinically-actionable molecular…”
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Bimekizumab in patients with active psoriatic arthritis: results from a 48-week, randomised, double-blind, placebo-controlled, dose-ranging phase 2b trial by Ritchlin, Christopher T, Kavanaugh, Arthur, Merola, Joseph F, Schett, Georg, Scher, Jose U, Warren, Richard B, Gottlieb, Alice B, Assudani, Deepak, Bedford-Rice, Kathy, Coarse, Jason, Ink, Barbara, McInnes, Iain B

“…Dual neutralisation of interleukin 17A (IL17A) and interleukin 17F (IL17F) is a potential novel therapeutic approach in psoriatic arthritis. We assessed…”
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Strategies to Improve Outcomes in Psoriatic Arthritis by Ritchlin, Christopher, Scher, Jose U.

“…Purpose of Review The therapeutic response to biologic agents in psoriasis is significantly higher than observed in psoriatic arthritis (PsA). In this review,…”
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