Search Results - "Schepmoes, Athena A."
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Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations
Published in The journal of clinical endocrinology and metabolism (01-05-2016)“…Context: Total 25-hydroxyvitamin D (25OHD) is a marker of vitamin D status and is lower in African Americans than in whites. Whether this difference holds for…”
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Establishing the proteome of normal human cerebrospinal fluid
Published in PloS one (11-06-2010)“…Knowledge of the entire protein content, the proteome, of normal human cerebrospinal fluid (CSF) would enable insights into neurologic and psychiatric…”
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Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes
Published in Nature communications (03-03-2022)“…Currently, no oral medications are available for type 1 diabetes (T1D). While our recent randomized placebo-controlled T1D trial revealed that oral verapamil…”
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Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum
Published in Proceedings of the National Academy of Sciences - PNAS (18-09-2012)“…Sensitive detection of low-abundance proteins in complex biological samples has typically been achieved by immunoassays that use antibodies specific to target…”
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Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes
Published in Annals of medicine (Helsinki) (12-12-2023)“…BACKGROUNDMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms particularly disabling fatigue…”
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Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses
Published in mBio (20-05-2014)“…The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While…”
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Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism
Published in Cell host & microbe (10-02-2016)“…Pandemic influenza viruses modulate proinflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids,…”
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MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses
Published in mSystems (01-05-2016)“…Integrative multi-omics analyses can empower more effective investigation and complete understanding of complex biological systems. Despite recent advances in…”
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Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
Published in PloS one (23-02-2011)“…Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology. They share features of fatigue and cognitive…”
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Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
Published in Cell reports. Medicine (21-04-2020)“…In the absence of a dominant driving mutation other than uniformly present TP53 mutations, deeper understanding of the biology driving ovarian high-grade…”
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Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy
Published in Molecular metabolism (Germany) (01-10-2022)“…Adipogenesis is a complex process controlled by intrinsic and extrinsic factors that regulate preadipocyte proliferation, adipogenic capacity and maturation of…”
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An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies
Published in Journal of proteome research (05-02-2010)“…A high-throughput approach and platform using 15 min reversed-phase capillary liquid chromatography (RPLC) separations in conjunction with ion mobility…”
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Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers
Published in Cell reports (Cambridge) (01-11-2016)“…Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of…”
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Proteomic Profiling of Nonenzymatically Glycated Proteins in Human Plasma and Erythrocyte Membranes
Published in Journal of proteome research (01-05-2008)“…Nonenzymatic glycation of peptides and proteins by d-glucose has important implications in the pathogenesis of diabetes mellitus, particularly in the…”
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15
Gray matter is targeted in first-attack multiple sclerosis
Published in PloS one (10-09-2013)“…The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain…”
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High and low doses of ionizing radiation induce different secretome profiles in a human skin model
Published in PloS one (18-03-2014)“…It is postulated that secreted soluble factors are important contributors of bystander effect and adaptive responses observed in low dose ionizing radiation…”
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Decrease in multiple complement proteins associated with development of islet autoimmunity and type 1 diabetes
Published in iScience (16-02-2024)“…Type 1 diabetes (T1D) is a chronic condition caused by autoimmune destruction of the insulin-producing pancreatic β cells. While it is known that…”
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Proteomics Coupled with Metabolite and Cell Wall Profiling Reveal Metabolic Processes of a Developing Rice Stem Internode
Published in Frontiers in plant science (13-07-2017)“…Internodes of grass stems function in mechanical support, transport, and, in some species, are a major sink organ for carbon in the form of cell wall polymers…”
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Improved Methods for the Enrichment and Analysis of Glycated Peptides
Published in Analytical chemistry (Washington) (15-12-2008)“…Nonenzymatic glycation of tissue proteins has important implications in the development of complications of diabetes mellitus. Herein we report improved…”
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Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection
Published in iScience (16-06-2023)“…Among all RNA viruses, coronavirus RNA transcription is the most complex and involves a process termed “discontinuous transcription” that results in the…”
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