Search Results - "Scheper, W"

Activation of the unfolded protein response in Parkinson’s disease by Hoozemans, J.J.M., van Haastert, E.S., Eikelenboom, P., de Vos, R.A.I., Rozemuller, J.M., Scheper, W.

“…Parkinson’s disease (PD) is, at the neuropathological level, characterized by the accumulation of misfolded proteins. The presence of misfolded proteins can…”
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gamma delta T cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia by Scheper, W, van Dorp, S, Kersting, S, Pietersma, F, Lindemans, C, Hol, S, Heijhuurs, S, Sebestyen, Z, Gruender, C, Marcu-Malina, V, Marchant, A, Donner, C, Plachter, B, Vermijlen, D, van Baarle, D, Kuball, J

“…Human cytomegalovirus (CMV) infections and relapse of disease remain major problems after allogeneic stem cell transplantation (allo-SCT), in particular in…”
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γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia by Scheper, W, van Dorp, S, Kersting, S, Pietersma, F, Lindemans, C, Hol, S, Heijhuurs, S, Sebestyen, Z, Gründer, C, Marcu-Malina, V, Marchant, A, Donner, C, Plachter, B, Vermijlen, D, van Baarle, D, Kuball, J

“…Human cytomegalovirus (CMV) infections and relapse of disease remain major problems after allogeneic stem cell transplantation (allo-SCT), in particular in…”
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Reference genes for gene expression analysis in the fungal pathogen Neonectria ditissima and their use demonstrating expression up-regulation of candidate virulence genes by Florez, Liz M, Scheper, Reiny W A, Fisher, Brent M, Sutherland, Paul W, Templeton, Matthew D, Bowen, Joanna K

“…European canker, caused by the necrotrophic fungal phytopathogen Neonectria ditissima, is one of the most damaging apple diseases worldwide. An understanding…”
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Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau by de Veij Mestdagh, C F, Witte, M E, Scheper, W, Smit, A B, Henning, R H, van Kesteren, R E

“…Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzheimer's disease. Interestingly,…”
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Hunting for clinical translation with innate-like immune cells and their receptors by Scheper, W, Gründer, C, Straetemans, T, Sebestyen, Z, Kuball, J

“…Allogeneic stem cell transplantation (allo-SCT) has so far been the most effective immunotherapy for hematological malignancies. However, it is becoming…”
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The unfolded protein response is activated in Alzheimer's disease by Hoozemans, J J M, Veerhuis, R, Van Haastert, E S, Rozemuller, J M, Baas, F, Eikelenboom, P, Scheper, W

“…Alzheimer's disease (AD) is, at the neuropathological level, characterized by the accumulation and aggregation of misfolded proteins. The presence of misfolded…”
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The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress by van der Harg, J M, Nölle, A, Zwart, R, Boerema, A S, van Haastert, E S, Strijkstra, A M, Hoozemans, J JM, Scheper, W

“…The unfolded protein response (UPR) is activated in neurodegenerative tauopathies such as Alzheimer’s disease (AD) in close connection with early stages of tau…”
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Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease by Nijholt, D A T, de Graaf, T R, van Haastert, E S, Oliveira, A Osório, Berkers, C R, Zwart, R, Ovaa, H, Baas, F, Hoozemans, J J M, Scheper, W

“…Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore cellular homeostasis…”
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The significance of neuroinflammation in understanding Alzheimer's disease by Eikelenboom, P, Veerhuis, R, Scheper, W, Rozemuller, A J M, van Gool, W A, Hoozemans, J J M

“…The interest of scientists in the involvement of inflammation-related mechanisms in the pathogenesis of Alzheimer's disease (AD) goes back to the work of one…”
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Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology by Wolzak, Kimberly, Vermunt, Lisa, Campo, Marta del, Jorge‐Oliva, Marta, Ziel, Anna Maria, Li, Ka Wan, Smit, August B., Chen‐Ploktkin, Alice, Irwin, David J., Lemstra, Afina W., Pijnenburg, Yolande, Flier, Wiesje, Zetterberg, Henrik, Gobom, Johan, Blennow, Kaj, Visser, Pieter Jelle, Teunissen, Charlotte E., Tijms, Betty M., Scheper, Wiep

“…INTRODUCTION Cerebrospinal fluid (CSF) biomarkers for specific cellular disease processes are lacking for tauopathies. In this translational study we aimed to…”
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Identification of a tumor-specific allo-HLA–restricted γδTCR by Kierkels, G.J.J., Scheper, W., Meringa, A.D., Johanna, I., Beringer, D.X., Janssen, A., Schiffler, M., Aarts-Riemens, T., Kramer, L., Straetemans, T., Heijhuurs, S., Leusen, J.H.W., San José, E., Fuchs, K., Griffioen, M., Falkenburg, J.H., Bongiovanni, L., de Bruin, A., Vargas-Diaz, D., Altelaar, M., Heck, A.J.R., Shultz, L.D., Ishikawa, F., Nishimura, M.I., Sebestyén, Z., Kuball, J.

“…γδT cells are key players in cancer immune surveillance because of their ability to recognize malignant transformed cells, which makes them promising…”
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Genetic mapping of the European canker (Neonectria ditissima) resistance locus Rnd1 from Malus ‘Robusta 5’ by Bus, Vincent G. M., Scheper, Reiny W. A., Walter, Monika, Campbell, Rebecca E., Kitson, Biff, Turner, Lauren, Fisher, Brent M., Johnston, Sarah L., Wu, Chen, Deng, Cecilia H., Singla, Gagandeep, Bowatte, Deepa, Jesson, Linley K., Hedderley, Duncan I., Volz, Richard K., Chagné, David, Gardiner, Susan E.

“…Current control strategies for the major apple disease European canker (EC) are laborious and expensive, and often do not prevent progression of the disease,…”
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Vertical landing for micro air vehicles using event‐based optical flow by Pijnacker Hordijk, Bas J., Scheper, Kirk Y. W., Croon, Guido C. H. E.

“…Small flying robots can perform landing maneuvers using bio‐inspired optical flow by maintaining a constant divergence. However, optical flow is typically…”
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BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells by Del Campo, M., Oliveira, C. R., Scheper, W., Zwart, R., Korth, C., Müller-Schiffmann, A., Kostallas, G., Biverstal, H., Presto, J., Johansson, J., Hoozemans, J. J., Pereira, C. F., Teunissen, C. E.

“…Alzheimer’s disease (AD) is pathologically characterized by the presence of misfolded proteins such as amyloid beta (Aβ) in senile plaques, and…”
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MISFOLDED BRI2 ECTODOMAIN ACTIVATES CRITICAL PATHOLOGICAL PATHWAYS INVOLVED IN EARLY STAGES OF ALZHEIMER'S DISEASE by Campo Milan, Marta Del, Pereira, Cláudia, Scheper, W, Zwart, R, Hoozemans, Jeroen, Oliveira, Catarina, Teunissen, Charlotte

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Removing protein aggregates: the role of proteolysis in neurodegeneration by Nijholt, D A T, De Kimpe, L, Elfrink, H L, Hoozemans, J J M, Scheper, W

“…A common characteristic of neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD) is the accumulation…”
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Real-time PCR for detection and quantification, and histological characterization of Neonectria ditissima in apple trees by Ghasemkhani, Marjan, Holefors, Anna, Marttila, Salla, Dalman, Kerstin, Zborowska, Anna, Rur, Mira, Rees-George, Jonathan, Nybom, Hilde, Everett, Kerry R., Scheper, Reiny W. A., Garkava-Gustavsson, Larisa

“…Key message We designed a pair of primers from a region of the β-tubulin gene to detect and quantify Neonectria ditissima in wood of some infected apple…”
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Protein Quality Control in Neurodegeneration: Walking the Tight Rope Between Health and Disease by Hol, E. M., Scheper, W.

“…Most neurodegenerative disorders are characterised by deposits of aggregated proteins that are readily visualised by light microscopy. Although the presence of…”
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Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress by Scheper, W., Hoozemans, J. J. M., Hoogenraad, C. C., Rozemuller, A. J. M., Eikelenboom, P., Baas, F.

“…Alzheimer's disease (AD) is characterized by deposits of aggregated proteins. Accumulation of aggregation‐prone proteins activates protein quality control…”
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