Search Results - "Scheper, R."

Hypertrophic and keloid scars fail to progress from the CD34−/α‐smooth muscle actin (α‐SMA)+ immature scar phenotype and show gradient differences in α‐SMA and p16 expression by Limandjaja, G.C., Belien, J.M., Scheper, R.J., Niessen, F.B., Gibbs, S.

“…Summary Background Our understanding of the pathogenesis underlying keloid scar formation is still very limited, and the morphological distinction between…”
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Increased epidermal thickness and abnormal epidermal differentiation in keloid scars by Limandjaja, G.C., Broek, L.J., Waaijman, T., Veen, H.A., Everts, V., Monstrey, S., Scheper, R.J., Niessen, F.B., Gibbs, S.

“…Summary Background The pathogenesis underlying keloid formation is still poorly understood. Research has focused mostly on dermal abnormalities, while the…”
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Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound by dos Santos, G. Galvão, Reinders, J., Ouwehand, K., Rustemeyer, T., Scheper, R.J., Gibbs, S.

“…Allergic contact dermatitis is the result of an adaptive immune response of the skin to direct exposure to an allergen. Since many chemicals are also…”
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Infection criteria, inoculum sources and splash dispersal pattern of Colletotrichum acutatum causing bitter rot of apple in New Zealand by Everett, K. R., Pushparajah, I. P. S., Timudo, O. E., Ah Chee, A., Scheper, R. W. A., Shaw, P. W., Spiers, T. M., Taylor, J. T., Wallis, D. R., Wood, P. N.

“…Infection of Malus x domestica cv. Royal Gala fruit by Colletotrichum acutatum causing bitter rot was studied in the temperate climate of New Zealand…”
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Palladium-induced Th2 cytokine responses reflect skin test reactivity by Muris, J., Feilzer, A. J., Kleverlaan, C. J., Rustemeyer, T., van Hoogstraten, I. M. W., Scheper, R. J., von Blomberg, B. M. E.

“…Recently, a crucial role of Th2 responses in nickel allergic contact dermatitis (ACD) was demonstrated. As palladium allergy is an issue of growing interest,…”
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Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients by HAANEN, J. B. A. G, BAARS, A, PINEDO, H. M, VAN DEN EERTWEGH, A. J. M, GOMEZ, R, WEDER, P, SMITS, M, DE GRUIJL, T. D, VON BLOMBERG, B. M. E, BLOEMENA, E, SCHEPER, R. J, VAN HAM, S. M

“…To study the effect of autologous tumor cell vaccinations on the presence and numbers of circulating CD8+ T cells specific for tumor-associated antigens (TAA)…”
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Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors by ARONICA, E, GORTER, J. A, JANSEN, G. H, VAN VEELEN, C. W. M, VAN RIJEN, P. C, LEENSTRA, S, RAMKEMA, M, SCHEFFER, G. L, SCHEPER, R. J, TROOST, D

“…The cell-specific distribution of multidrug resistance extrusion pumps was studied in developmental glioneuronal lesions, including focal cortical dysplasia…”
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Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFα by van der Heijden, J, de Jong, M C, Dijkmans, B A C, Lems, W F, Oerlemans, R, Kathmann, I, Schalkwijk, C G, Scheffer, G L, Scheper, R J, Jansen, G

“…Objective: To determine whether overexpression of cell membrane associated drug efflux pumps belonging to the family of ATP binding cassette (ABC) proteins…”
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Effect of successive cauliflower plantings and Rhizoctonia solani AG 2-1 inoculations on disease suppressiveness of a suppressive and a conducive soil by Postma, J., Scheper, R.W.A., Schilder, M.T.

“…Disease suppressiveness against Rhizoctonia solani AG 2-1 in cauliflower was studied in two marine clay soils with a sandy loam texture. The soils had a…”
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Analysis of effector and regulatory immune reactivity to nickel by Rustemeyer, T., Von Blomberg, B. M. E., Van Hoogstraten, I. M. W., Bruynzeel, D. P., Scheper, R. J.

“…Summary Background Diagnostic patch testing in allergic contact dermatitis faces the risk of boosting existing hypersensitivities or active sensitization…”
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Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines by KOOL, M, DE HAAS, M, SCHEFFER, G. L, SCHEPER, R. J, VAN EIJK, M. J. T, JUIJN, J. A, BAAS, F, BORST, P

“…By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1, the gene encoding the multidrug resistance-associated…”
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The Human Multidrug Resistance-Associated Protein MRP is a Plasma Membrane Drug-Efflux Pump by Zaman, G. J. R., Flens, M. J., van Leusden, M. R., de Haas, M., Mulder, H. S., Lankelma, J., Pinedo, H. M., Scheper, R. L., Baas, F., broxterman, H. J., Borst, P.

“…The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor cells to cytotoxic drugs. We…”
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A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin‐Johnson syndrome by Paulusma, C C, Kool, M, Bosma, P J, Scheffer, G L, ter Borg, F, Scheper, R J, Tytgat, G N, Borst, P, Baas, F, Elferink, R O

“…The human Dubin‐Johnson syndrome (DJS) is a rare autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. Patients have…”
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Vascular colocalization of P-glycoprotein, multidrug-resistance associated protein 1, breast cancer resistance protein and major vault protein in human epileptogenic pathologies by Sisodiya, S. M., Martinian, L., Scheffer, G. L., Van Der Valk, P., Scheper, R. J., Harding, B. N., Thom, M.

“…Multidrug transporters, such as P‐glycoprotein (P‐gp), multidrug‐resistance associated protein 1 (MRP1) and breast cancer resistance protein (BCRP), are…”
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A cytotoxic analysis of antiseptic medication on skin substitutes and autograft by Duc, Q. le, Breetveld, M., Middelkoop, E., Scheper, R.J., Ulrich, M.M.W., Gibbs, S.

“…Summary Background  There is an increasing demand for the clinical application of human skin substitutes (HSSs) for treating ulcers, burns and surgical wounds…”
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Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial by Vermorken, Jan B, Claessen, Anke ME, van Tinteren, Harm, Gall, Helen E, Ezinga, Renate, Meijer, Sybren, Scheper, Rik J, Meijer, Chris JLM, Bloemena, Elizabeth, Ransom, Janet H, Hanna, Michael G, Pinedo, Herbert M

“…Colon cancer is curable by surgery, but cure rate depends on the extent of disease. We investigated whether adjuvant active specific immunotherapy (ASI) with…”
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Autologous full-thickness skin substitute for healing chronic wounds by Gibbs, S., Van Den Hoogenband, H.M., Kirtschig, G., Richters, C.D., Spiekstra, S.W., Breetveld, M., Scheper, R.J., De Boer, E.M.

“…Summary Background  Chronic wounds represent a major problem to our society. Therefore, advanced wound‐healing strategies for the treatment of these wounds are…”
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Multidrug resistance related molecules in human and murine lung by Scheffer, G L, Pijnenborg, A C L M, Smit, E F, Müller, M, Postma, D S, Timens, W, van der Valk, P, de Vries, E G E, Scheper, R J

“…Aims: Transporter proteins known to mediate multidrug resistance (MDR) in tumour cells—MDR1 P-glycoprotein (P-gp) and multidrug resistance related protein 1…”
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Tissue distribution of the multidrug resistance protein by Flens, MJ, Zaman, GJ, van der Valk, P, Izquierdo, MA, Schroeijers, AB, Scheffer, GL, van der Groep, P, de Haas, M, Meijer, CJ, Scheper, RJ

“…The human multidrug resistance protein (MRP) is a 190 kd membrane glycoprotein that can cause resistance of human tumor cells to various anticancer drugs, by…”
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Expression of drug pathway proteins is independent of tumour type by Zhang, W, Shannon, WD, Duncan, J, Scheffer, GL, Scheper, RJ, McLeod, HL

“…Current clinicopathological staging systems have the advantage of standardized criteria for assessing tumour stage, and a relationship between advancing tumour…”
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