Search Results - "Scheper, Mirte"

miR-193b-3p/ PGC-1α pathway regulates an insulin dependent anti-inflammatory response in Parkinson's disease by Mesarosova, Lucia, Scheper, Mirte, Iyer, Anand, Anink, Jasper J., Mills, James D., Aronica, Eleonora

“…It has been shown that many miRNAs, including miR-193b-3p, are differentially expressed in Parkinson's disease (PD). Dysregulation of miR-193b-3p/PGC-1α axis…”
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Is tuberous sclerosis complex-associated autism a preventable and treatable disorder? by Curatolo, Paolo, Scheper, Mirte, Emberti Gialloreti, Leonardo, Specchio, Nicola, Aronica, Eleonora

“…Background Tuberous sclerosis complex (TSC) is a genetic disorder caused by inactivating mutations in the TSC1 and TSC2 genes, causing overactivation of the…”
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Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes by Luinenburg, Mark J, Scheper, Mirte, Sørensen, Frederik N F, Anink, Jasper J, Van Hecke, Wim, Korshunova, Irina, Jansen, Floor E, Riney, Kate, van Eijsden, Pieter, Gosselaar, Peter, Mills, James D, Kalf, Rozemarijn S, Zimmer, Till S, Broekaart, Diede W M, Khodosevich, Konstantin, Aronica, Eleonora, Mühlebner, Angelika

“…Constitutive activation of the mTOR pathway, as observed in Tuberous Sclerosis Complex (TSC), leads to glial dysfunction and subsequent epileptogenesis…”
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miRNAs and isomiRs: Serum-Based Biomarkers for the Development of Intellectual Disability and Autism Spectrum Disorder in Tuberous Sclerosis Complex by Scheper, Mirte, Romagnolo, Alessia, Besharat, Zein Mersini, Iyer, Anand M, Moavero, Romina, Hertzberg, Christoph, Weschke, Bernhard, Riney, Kate, Feucht, Martha, Scholl, Theresa, Petrak, Borivoj, Maulisova, Alice, Nabbout, Rima, Jansen, Anna C, Jansen, Floor E, Lagae, Lieven, Urbanska, Malgorzata, Ferretti, Elisabetta, Tempes, Aleksandra, Blazejczyk, Magdalena, Jaworski, Jacek, Kwiatkowski, David J, Jozwiak, Sergiusz, Kotulska, Katarzyna, Sadowski, Krzysztof, Borkowska, Julita, Curatolo, Paolo, Mills, James D, Aronica, Eleonora

“…Tuberous sclerosis complex (TSC) is a rare multi-system genetic disorder characterized by a high incidence of epilepsy and neuropsychiatric manifestations…”
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mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment by Ravizza, Teresa, Scheper, Mirte, Di Sapia, Rossella, Gorter, Jan, Aronica, Eleonora, Vezzani, Annamaria

“…Epilepsy remains a major health concern as anti-seizure medications frequently fail, and there is currently no treatment to stop or prevent epileptogenesis,…”
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Dysregulation of miR‐543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1 by Scheper, Mirte, Iyer, Anand, Anink, Jasper J., Mesarosova, Lucia, Mills, James D., Aronica, Eleonora

“…Aims Parkinson's disease (PD) is a progressive and age‐dependent neurodegenerative disease characterised clinically by a variety of motor symptoms and…”
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Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study by Vliet, Erwin A., Scheper, Mirte, Mills, James D., Puhakka, Noora, Szydlowska, Kinga, Ferracin, Manuela, Lovisari, Francesca, Soukupova, Marie, Zucchini, Silvia, Srivastava, Prashant K., Johnson, Michael R., Lukasiuk, Katarzyna, Gorter, Jan A., Aronica, Eleonora, Pitkänen, Asla, Simonato, Michele

“…Objective Structural epilepsies can manifest months or years after the occurrence of an initial epileptogenic insult, making them amenable for secondary…”
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Levamisole suppresses activation and proliferation of human T cells by the induction of a p53‐dependent DNA damage response by Khan, Gerarda H., Veltkamp, Floor, Scheper, Mirte, Hoebe, Ron A., Claessen, Nike, Butter, Loes, Bouts, Antonia H.M., Florquin, Sandrine, Guikema, Jeroen E. J.

“…Abstract Levamisole (LMS) is a small molecule used in the treatment of idiopathic nephrotic syndrome (INS). The pathogenesis of INS remains unknown, but…”
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Astroglial calcium signaling and homeostasis in tuberous sclerosis complex by Romagnolo, Alessia, Dematteis, Giulia, Scheper, Mirte, Luinenburg, Mark J., Mühlebner, Angelika, Van Hecke, Wim, Manfredi, Marcello, De Giorgis, Veronica, Reano, Simone, Filigheddu, Nicoletta, Bortolotto, Valeria, Tapella, Laura, Anink, Jasper J., François, Liesbeth, Dedeurwaerdere, Stefanie, Mills, James D., Genazzani, Armando A., Lim, Dmitry, Aronica, Eleonora

“…Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors in various organs, including the brain,…”
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Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex by Scheper, Mirte, Sørensen, Frederik N. F., Ruffolo, Gabriele, Gaeta, Alessandro, Lissner, Lilian J., Anink, Jasper J., Korshunova, Irina, Jansen, Floor E., Riney, Kate, van Hecke, Wim, Mühlebner, Angelika, Khodosevich, Konstantin, Schubert, Dirk, Palma, Eleonora, Mills, James D., Aronica, Eleonora

“…GABAergic interneurons play a critical role in maintaining neural circuit balance, excitation–inhibition regulation, and cognitive function modulation. In…”
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