Search Results - "Schense, Jason C"

Repair of bone defects using synthetic mimetics of collagenous extracellular matrices by Hubbell, Jeffrey A, Lutolf, Matthias P, Weber, Franz E, Schmoekel, Hugo G, Schense, Jason C, Kohler, Thomas, Müller, Ralph

“…We have engineered synthetic poly(ethylene glycol) (PEG)-based hydrogels as cell-ingrowth matrices for in situ bone regeneration. These networks contain a…”
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Bone healing induced by local delivery of an engineered parathyroid hormone prodrug by Arrighi, Isabelle, Mark, Silke, Alvisi, Monica, von Rechenberg, Brigitte, Hubbell, Jeffrey A, Schense, Jason C

“…Abstract Regenerative medicine requires innovative therapeutic designs to accommodate high morphogen concentrations in local depots, provide their sustained…”
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Covalently conjugated VEGF–fibrin matrices for endothelialization by Zisch, Andreas H., Schenk, Ursula, Schense, Jason C., Sakiyama-Elbert, Shelly E., Hubbell, Jeffrey A.

“…Vascular endothelial growth factor (VEGF) is a key factor in endothelial cell biology and blood vessel formation and a candidate therapeutic for the…”
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A novel, tissue occlusive poly(ethylene glycol) hydrogel material by Wechsler, Sandra, Fehr, Daniel, Molenberg, Aart, Raeber, George, Schense, Jason C., Weber, Franz E.

“…The use of guided bone regeneration (GBR) techniques requires new materials meeting the needs of clinical application. Design criteria for GBR devices are…”
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Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices by Schmoekel, Hugo G., Weber, Franz E., Schense, Jason C., Grätz, Klaus W., Schawalder, Peter, Hubbell, Jeffrey A.

“…Most growth factors naturally involved in development and regeneration demonstrate strong binding to the extracellular matrix and are retained there until…”
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Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension by Hubbell, Jeffrey A, Schense, Jason C, Bloch, Jocelyne, Aebischer, Patrick

“…Fibrin plays an important role in wound healing and regeneration, and enjoys widespread use in surgery and tissue engineering. The enzymatic activity of Factor…”
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Cross-Linking Exogenous Bifunctional Peptides into Fibrin Gels with Factor XIIIa by Schense, Jason C, Hubbell, Jeffrey A

“…Bi-domain peptides with a factor XIIIa substrate in one domain and a bioactive peptide in another domain were covalently incorporated into fibrin gels during…”
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Three-dimensional Migration of Neurites Is Mediated by Adhesion Site Density and Affinity by Schense, Jason C., Hubbell, Jeffrey A.

“…Three-dimensional neurite outgrowth rates within fibrin matrices that contained variable amounts of RGD peptides were shown to depend on adhesion site density…”
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Incorporation of heparin‐binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering by SAKIYAMA, SHELLY E., SCHENSE, JASON C., HUBBELL, JEFFREY A.

“…ABSTRACT The goal of this work was to improve the potential of fibrin to promote nerve regeneration by enzymatically incorporating exogenous neurite‐promoting…”
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Bone healing in the rat and dog with nonglycosylated BMP-2 demonstrating low solubility in fibrin matrices by Schmoekel, Hugo, Schense, Jason C, Weber, Franz E, Grätz, Klaus W, Gnägi, Dania, Müller, Ralph, Hubbell, Jeffrey A

“…A novel form of recombinant human bone morphogenetic protein-2 (BMP-2) was explored for effective incorporation and long-term retention into fibrin ingrowth…”
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Fibronectin modulates macrophage adhesion and FBGC formation: The role of RGD, PHSRN, and PRRARV domains by Kao, Weiyuan John, Lee, Damian, Schense, Jason C., Hubbell, Jeffrey A.

“…To probe the role of human plasma fibronectin in modulating human blood‐derived macrophage adhesion and fusion to form multinucleated foreign‐body giant cells…”
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Treatment of nonunions with nonglycosylated recombinant human bone morphogenetic protein-2 delivered from a fibrin matrix by Schmökel, Hugo G, Weber, Franz E, Seiler, Gabriela, von Rechenberg, Brigitte, Schense, Jason C, Schawalder, Peter, Hubbell, Jeffrey

“…To report the results of the treatment of nonunions with nonglycosylated recombinant human bone morphogenetic protein-2 (nglBMP-2) delivered from a designed…”
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Treatment of Nonunions with Nonglycosylated Recombinant Human Bone Morphogenetic Protein-2 Delivered from aFibrinMatrix by Schmökel, Hugo G., Weber, Franz E., Seiler, Gabriela, Von Rechenberg, Brigitte, Schense, Jason C., Schawalder, Peter, Hubbell, Jeffrey

“…Objective— To report the results of the treatment of nonunions with nonglycosylated recombinant human bone morphogenetic protein‐2 (nglBMP‐2) delivered from a…”
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Enhanced endothelial cell retention on shear-stressed synthetic vascular grafts precoated with RGD-cross-linked fibrin by Meinhart, Johann G, Schense, Jason C, Schima, Heinrich, Gorlitzer, Michael, Hubbell, Jeff A, Deutsch, Manfred, Zilla, Peter

“…Clinical in vitro endothelialization has been shown to increase the patency of synthetic vascular grafts. The shear stress resistance of the cultured…”
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Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices: Fibrin-Binding BMP-2 in Bone Healing by Schmoekel, Hugo G., Weber, Franz E., Schense, Jason C., Grätz, Klaus W., Schawalder, Peter, Hubbell, Jeffrey A.

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