Intragastric Balloon in Association with Lifestyle and/or Pharmacotherapy in the Long-Term Management of Obesity

Intragastric Balloon in Association with Lifestyle and/or Pharmacotherapy in the Long-Term Management of Obesity

Background Intragastric balloon (BioEnterics Intragastric Balloon, BIB®) or pharmacotherapy are possible options for the treatment of obese patients when traditional approaches have failed. The aim of our study was to compare in obese patients the effect on weight loss and metabolic changes of lifes...

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Bibliographic Details
Published in:Obesity surgery Vol. 22; no. 4; pp. 565 - 571
Main Authors: Farina, Maria Grazia, Baratta, Roberto, Nigro, Angela, Vinciguerra, Federica, Puglisi, Concetta, Schembri, Roberto, Virgilio, Clara, Vigneri, Riccardo, Frittitta, Lucia
Format: Journal Article
Language:English
Published: New York Springer-Verlag 01-04-2012
Springer Nature B.V
Subjects:
Adolescent
Adult
Appetite Depressants - therapeutic use
Clinical Research
Combined Modality Therapy
Cyclobutanes - therapeutic use
Diet
Drug therapy
Exercise
Female
Gastric Balloon
Humans
Italy - epidemiology
Male
Medical procedures
Medicine
Medicine & Public Health
Middle Aged
Obesity
Obesity - drug therapy
Obesity - epidemiology
Obesity - surgery
Obesity - therapy
Risk Reduction Behavior
Surgery
Time Factors
Treatment Outcome
Weight control
Weight Loss
Young Adult
Italy
BIB
Obesity therapy
Sibutramine
Lifestyle intervention
Intragastric balloon
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Summary:Background Intragastric balloon (BioEnterics Intragastric Balloon, BIB®) or pharmacotherapy are possible options for the treatment of obese patients when traditional approaches have failed. The aim of our study was to compare in obese patients the effect on weight loss and metabolic changes of lifestyle modifications associated with either BIB or pharmacotherapy or the two treatments in sequence as a maintenance strategy for weight loss. Methods Fifty obese patients were recruited and randomly assigned to lifestyle modifications combined with either BIB for 6 months ( n  = 30) or sibutramine (pharmacotherapy group) for 1 year ( n  = 20). After BIB removal, patients were randomly assigned to either correct lifestyle (BIB/lifestyle) or lifestyle plus pharmacotherapy (BIB/pharmacotherapy). Results At 6 months, patients treated with BIB lost significantly ( P  < 0.05) more weight (percent of initial weight lost, %IWL = 14.5 ± 1.2; percent of excess BMI lost, %EBL = 37.7 ± 3.2) than patients who received pharmacological treatment (%IWL = 9.1 ± 1.5, %EBL = 25.3 ± 4.1). At 1 year, the weight lost was significantly ( P  < 0.05) greater in patients treated with either BIB/pharmacotherapy (%IWL = 15.8 ± 2.3%, %EBL = 41.3 ± 6.7%) or BIB/lifestyle (%IWL = 14.3 ± 2.7, %EBL = 34.9 ± 6.5%) in respect to pharmacotherapy group (%IWL = 8.0 ± 1.4%, %EBL = 22.1 ± 3.9%). Moreover, patients treated sequentially with BIB/lifestyle or BIB/pharmacotherapy showed a significant ( P  < 0.05) improvement in insulin sensitivity and triglycerides levels. Conclusions BIB represents an efficacious long-term obesity treatment when supplemental strategies, as lifestyle modifications or pharmacotherapy, are established for weight maintenance after its removal.
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ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-011-0514-y