Search Results - "Schemann, M"

Obituary ‐ Hans Jörg Ehrlein by Schemann, M.

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Irritable bowel syndrome by Enck, Paul, Aziz, Qasim, Barbara, Giovanni, Farmer, Adam D., Fukudo, Shin, Mayer, Emeran A., Niesler, Beate, Quigley, Eamonn M. M., Rajilić-Stojanović, Mirjana, Schemann, Michael, Schwille-Kiuntke, Juliane, Simren, Magnus, Zipfel, Stephan, Spiller, Robin C.

“…Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients,…”
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The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome by Klooker, Tamira K, Braak, Breg, Koopman, Karin E, Welting, Olaf, Wouters, Mira M, van der Heide, Sicco, Schemann, Michael, Bischoff, Stephan C, van den Wijngaard, Rene M, Boeckxstaens, Guy E

“…Mast cell activation is thought to be involved in visceral hypersensitivity, one of the main characteristics of the irritable bowel syndrome (IBS). A study was…”
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Sensory transmission in the gastrointestinal tract by Blackshaw, L. A., Brookes, S. J. H., Grundy, D., Schemann, M.

“…The gastrointestinal (GI) tract must balance ostensibly opposite functions. On the one hand, it must undertake the process of digestion and absorption of…”
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Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome by Nasser, Y., Boeckxstaens, G. E., Wouters, M. M., Schemann, M., Vanner, S.

“…Background Although animal models of the irritable bowel syndrome (IBS) have provided important insights, there are no models that fully express the features…”
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The human enteric nervous system by Schemann, M., Neunlist, M.

“…Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it…”
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Ginger and its pungent constituents non‐competitively inhibit activation of human recombinant and native 5‐HT3 receptors of enteric neurons by Walstab, J., Krüger, D., Stark, T., Hofmann, T., Demir, I. E., Ceyhan, G. O., Feistel, B., Schemann, M., Niesler, B.

“…Background Beneficial effects of ginger in the treatment of gastrointestinal (GI) problems and chemotherapy‐induced nausea and vomiting are well accepted. In…”
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Fast calcium and voltage‐sensitive dye imaging in enteric neurones reveal calcium peaks associated with single action potential discharge by Michel, K., Michaelis, M., Mazzuoli, G., Mueller, K., Vanden Berghe, P., Schemann, M.

“…Non‐technical summary  Imaging of slow, long‐lasting changes in intracellular Ca2+ levels ([Ca2+]i) is a common method to assess neuronal activity. We found…”
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bis‐(p‐hydroxyphenyl)‐pyridyl‐2‐methane (BHPM)—the active metabolite of the laxatives bisacodyl and sodium picosulfate—enhances contractility and secretion in human intestine in vitro by Krueger, D., Demir, I. E., Ceyhan, G. O., Zeller, F., Schemann, M.

“…Background Stimulant laxatives are widely used to treat constipation. We investigated in human small and large intestinal preparations the effects of…”
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Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine by Krueger, D., Michel, K., Allam, S., Weiser, T., Demir, I. E., Ceyhan, G. O., Zeller, F., Schemann, M.

“…Background Hyoscine butylbromide (HBB, Buscopan®) is clinically used to treat intestinal cramps and visceral pain. Various studies, mainly on animal tissues,…”
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Tryptase potentiates enteric nerve activation by histamine and serotonin: Relevance for the effects of mucosal biopsy supernatants from irritable bowel syndrome patients by Ostertag, D., Annahazi, A., Krueger, D., Michel, K., Demir, I. E., Ceyhan, G. O., Zeller, F., Schemann, M.

“…Background We previously showed that mucosal biopsy supernatants from irritable bowel syndrome patients activated neurons despite low concentrations of…”
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Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients by Buhner, S., Li, Q., Berger, T., Vignali, S., Barbara, G., De Giorgio, R., Stanghellini, V., Schemann, M.

“…Background  We previously showed that colonic mucosal biopsy supernatants from patients with irritable bowel syndrome (IBS) activate neurons of the human…”
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High prevalence and functional effects of serum antineuronal antibodies in patients with gastrointestinal disorders by Lütt, A., Michel, K., Krüger, D., Volz, M. S., Nassir, M., Schulz, E., Poralla, L., Tangermann, P., Bojarski, C., Höltje, M., Teegen, B., Stöcker, W., Schemann, M., Siegmund, B., Prüss, H.

“…Background Antineuronal antibodies can be associated with both gastrointestinal (GI) and brain disorders. For example, antibodies against the potassium channel…”
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5‐HT receptors on interstitial cells of Cajal, smooth muscle and enteric nerves by Wouters, M. M., Farrugia, G., Schemann, M.

“…The majority of the body's serotonin (5‐HT) is produced by the gastrointestinal tract. 5‐HT has several functions in the gastrointestinal tract. 5‐HT is a…”
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Signaling mechanisms involved in the intestinal pro‐secretory actions of hydrogen sulfide by Krueger, D., Foerster, M., Mueller, K., Zeller, F., Slotta‐huspenina, J., Donovan, J., Grundy, D., Schemann, M.

“…Background  H2S actions in the gut involve neural activation. This study aimed to reveal the signaling mechanisms responsible for the pro‐secretory effect of…”
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Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X1, P2X2, P2X3 channels, P2Y and A3 metabotropic receptors in neurotransmission by Liñán-Rico, A., Wunderlich, J.E., Enneking, J.T., Tso, D.R., Grants, I., Williams, K.C., Otey, A., Michel, K., Schemann, M., Needleman, B., Harzman, A., Christofi, F.L.

“…The role of purinergic signaling in human ENS is not well understood. We sought to further characterize the neuropharmacology of purinergic receptors in human…”
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The multi‐herbal drug STW 5 (Iberogast®) has prosecretory action in the human intestine by Krueger, D., Gruber, L., Buhner, S., Zeller, F., Langer, R., Seidl, S., Michel, K., Schemann, M.

“…There is growing evidence that STW 5 (Iberogast®, fixed combination of hydroethanolic herbal extracts), besides being effective in functional dyspepsia, also…”
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Leptin excites enteric neurons of guinea‐pig submucous and myenteric plexus by Reichardt, F., Krueger, D., Schemann, M.

“…Background  Leptin, one of the most prominent mediators released from adipocytes, influences neuronal activity in the central nervous system. The enteric…”
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Region-specific effects of STW 5 (Iberogast ® ) and its components in gastric fundus, corpus and antrum by Schemann, M., Michel, K., Zeller, F., Hohenester, B., Rühl, A.

“…Functional dyspepsia (FD) is a disorder that involves impaired gastric accommodation, antral hypomotility, and upper abdominal pain. The herbal drug STW 5…”
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Changes in chemical coding of myenteric neurones in ulcerative colitis by Neunlist, M, Aubert, P, Toquet, C, Oreshkova, T, Barouk, J, Lehur, P A, Schemann, M, Galmiche, J P

“…Background: Morphological and functional changes in the enteric nervous system (ENS) have been reported in inflammatory bowel diseases but it is still…”
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